Diet–microbiota interactions and personalized nutrition

Nature Reviews Microbiology, Journal Year: 2019, Volume and Issue: 17(12), P. 742 - 753

Published: Sept. 20, 2019

Language: Английский

---

Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries

Gut, Journal Year: 2020, Volume and Issue: 69(7), P. 1218 - 1228

Published: Feb. 17, 2020

Objective Ageing is accompanied by deterioration of multiple bodily functions and inflammation, which collectively contribute to frailty. We others have shown that frailty co-varies with alterations in the gut microbiota a manner accelerated consumption restricted diversity diet. The Mediterranean diet (MedDiet) associated health. In NU-AGE project, we investigated if 1-year MedDiet intervention could alter reduce Design profiled 612 non-frail or pre-frail subjects across five European countries (UK, France, Netherlands, Italy Poland) before after administration 12-month long tailored elderly (NU-AGE diet). Results Adherence was specific microbiome alterations. Taxa enriched adherence were positively several markers lower improved cognitive function, negatively inflammatory including C-reactive protein interleukin-17. Analysis inferred microbial metabolite profiles indicated diet-modulated change an increase short/branch chained fatty acid production secondary bile acids, p-cresols, ethanol carbon dioxide. Microbiome ecosystem network analysis showed bacterial taxa responded occupy keystone interaction positions, whereas frailty-associated are peripheral networks. Conclusion Collectively, our findings support feasibility improving habitual modulate turn has potential promote healthier ageing.

Language: Английский

---

Global patterns and trends in colorectal cancer incidence in young adults

Gut, Journal Year: 2019, Volume and Issue: 68(12), P. 2179 - 2185

Published: Sept. 5, 2019

Objective Early-onset colorectal cancer (CRC) is increasing in the USA despite rapid declines older ages. Similar patterns are reported Australia and Canada, but a comprehensive global analysis of contemporary data lacking. Design We extracted long-term from Cancer Incidence Five Continents supplemental sources to report on worldwide CRC incidence rates trends by age (20–49 years ≥50 years) through diagnosis year 2012 or beyond (Australia, Finland, New Zealand, Norway, Sweden, USA). Results During 2008–2012, age-standardised adults <50 ranged 3.5 per 100 000 (95% CI 3.2 3.9) India (Chennai) 12.9 12.6 13.3) Korea. most recent decade available data, was stable 14 36 countries; declined Austria, Italy Lithuania; increased 19 countries, nine which had declining Denmark, Germany, Slovenia, UK In Cyprus, Netherlands inclines young were twice as those (eg, Norway average annual cent change (AAPC), 1.9 1.4 2.5) vs 0.5 0.3 0.7)). Among high-income countries with uptick early-onset disease began mid-1990s. The steepest increases Korea (AAPC, 4.2 3.4 5.0)) Zealand 4.0 2.1 6.0)). Conclusion exclusively spanning three continents, potentially signalling changes early-life exposures that influence large bowel carcinogenesis.

Language: Английский

---

The Intestinal Microbiota in Colorectal Cancer

Cancer Cell, Journal Year: 2018, Volume and Issue: 33(6), P. 954 - 964

Published: April 12, 2018

Language: Английский

---

Human Gut Microbiome: Function Matters

Trends in Microbiology, Journal Year: 2017, Volume and Issue: 26(7), P. 563 - 574

Published: Nov. 23, 2017

Language: Английский

---