Precision Microbiome Modulation with Discrete Dietary Fiber Structures Directs Short-Chain Fatty Acid Production

Cell Host & Microbe, Journal Year: 2020, Volume and Issue: 27(3), P. 389 - 404.e6

Published: Jan. 30, 2020

Language: Английский

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Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation

Cell, Journal Year: 2022, Volume and Issue: 185(16), P. 2879 - 2898.e24

Published: Aug. 1, 2022

Language: Английский

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Mass spectrometry-based metabolomics in microbiome investigations

Nature Reviews Microbiology, Journal Year: 2021, Volume and Issue: 20(3), P. 143 - 160

Published: Sept. 22, 2021

Language: Английский

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Individual risk management strategy and potential therapeutic options for the COVID-19 pandemic

Clinical Immunology, Journal Year: 2020, Volume and Issue: 215, P. 108409 - 108409

Published: April 7, 2020

Language: Английский

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Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota–Immune System Interplay. Implications for Health and Disease

Nutrients, Journal Year: 2021, Volume and Issue: 13(2), P. 699 - 699

Published: Feb. 22, 2021

The most prevalent diseases of our time, non-communicable (NCDs) (including obesity, type 2 diabetes, cardiovascular and some types cancer) are rising worldwide. All them share the condition an “inflammatory disorder”, with impaired immune functions frequently caused or accompanied by alterations in gut microbiota. These multifactorial maladies also have common malnutrition related to physiopathology. In this context, diet is greatest modulator system–microbiota crosstalk, much interest, new challenges, arising area precision nutrition as a way towards treatment prevention. It fact that westernized (WD) partly responsible for increased prevalence NCDs, negatively affecting both microbiota system. Conversely, other nutritional approaches, such Mediterranean (MD), positively influence system microbiota, proposed not only potential tool clinical management different disease conditions, but prevention health promotion globally. Thus, purpose review determine regulatory role components WD MD interplay, order understand, create awareness of, over key components.

Language: Английский

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Intestinal Flora and Disease Mutually Shape the Regional Immune System in the Intestinal Tract

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: April 3, 2020

The intestinal tract is the largest digestive organ in human body. It colonized by, and consistently exposed to, a myriad of microorganisms, including bifidobacteria, lactobacillus, Escherichia coli, enterococcus, clostridium perfringens, pseudomonas. To protect body from potential pathogens, has evolved regional immune characteristics. These characteristics are defined by its unique structure, function, microenvironment, which differ drastically those common central peripheral organs. microenvironment created flora products significantly affects function region. In turn, specific diseases regulate influence composition flora. A constant interplay occurs between system. Further, can be reconstructed probiotic use or microbiota transplantation, functioning to recalibrate homeostasis, while also contributing treatment amelioration diseases. this review, we summarize relationship occurrence development as an in-turn effect on immunity. We discuss improved it relates non-specific proliferation, differentiation secretion cells, within region following remodeling means ameliorate treat Finally, suggest strategies for utilization

Language: Английский

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The mutual interplay of gut microbiota, diet and human disease

FEBS Journal, Journal Year: 2020, Volume and Issue: 287(5), P. 833 - 855

Published: Jan. 19, 2020

The intestinal milieu harbours the gut microbiota, consisting of a complex community bacteria, archaea, fungi, viruses and protozoans that bring to host organism an endowment cells genes more numerous than its own. In last 10 years, mounting evidence has highlighted prominent influence mutualistic bacterial communities on human health. Microbial colonization occurs alongside with immune system development plays role in physiology. microbiota does not undergo significant fluctuations throughout adult life. However, infections, antibiotic treatment, lifestyle, surgery diet might profoundly affect it. Gut dysbiosis, defined as marked alterations amount function microorganisms, is correlated aetiology chronic noncommunicable diseases, ranging from cardiovascular, neurologic, respiratory metabolic illnesses cancer. this review, we focus interplay among provide perspective their unique metabolites pathogenesis and/or progression various disorders. We discuss interventions based microbiome studies, faecal transplantation, probiotics prebiotics, introduce concept correcting dysbiosis can ameliorate disease symptoms, thus offering new approach towards treatment.

Language: Английский

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Where to Look into the Puzzle of Polyphenols and Health? The Postbiotics and Gut Microbiota Associated with Human Metabotypes

Molecular Nutrition & Food Research, Journal Year: 2020, Volume and Issue: 64(9)

Published: March 20, 2020

Abstract The full consensus on the role of dietary polyphenols as human‐health‐promoting compounds remains elusive. two‐way interaction between and gut microbiota (GM) (i.e., modulation GM by their catabolism GM) is determinant in polyphenols’ effects. identification human metabotypes associated with a differential microbial metabolism has opened new research scenarios to explain inter‐individual variability upon consumption. unequivocally identified so far are those involved isoflavones (equol and(or) O ‐desmethylangolesin producers versus non‐producers) ellagic acid (urolithin metabotypes, including only urolithin‐A (UM‐A), urolithin‐A, isourolithin‐A, urolithin‐B (UM‐B), non‐producers (UM‐0)). In addition, metabolites (phenolic‐derived postbiotics) such equol, urolithins, valerolactones, enterolactone, enterodiol, 8‐prenylnaringenin, among others, can exert health knowledge updated position taken here i) polyphenols, ii) evidence phenolic‐derived postbiotics health, iii) biomarkers clustering individuals depending (metabotyping) effects, iv) catecholamines illustrate intersection personalized nutrition precision medicine.

Language: Английский

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The microbiome–gut–brain axis in Parkinson disease — from basic research to the clinic

Nature Reviews Neurology, Journal Year: 2022, Volume and Issue: 18(8), P. 476 - 495

Published: June 24, 2022

Language: Английский

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An in vitro batch fermentation protocol for studying the contribution of food to gut microbiota composition and functionality

Nature Protocols, Journal Year: 2021, Volume and Issue: 16(7), P. 3186 - 3209

Published: June 4, 2021

Language: Английский

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