npj Clean Water,
Journal Year:
2020,
Volume and Issue:
3(1)
Published: Feb. 19, 2020
Abstract
Antibiotics
are
widely
used
in
animal
husbandry,
and
various
types
of
antibiotic
resistance
genes
(ARGs)
frequently
detected
livestock
waste
around
the
world.
Conventional
treatment
processes
do
not
completely
remove
ARGs,
resulting
their
release
to
soil
water
environments.
Various
exposure
routes
these
ARGs
humans,
including
inhalation
ingestion
antibiotic-resistant
bacteria
(ARB)
that
harbor
them,
may
be
contributing
rise
resistant
clinical
infections
increasingly
difficult
treat
with
antibiotics.
In
this
review,
we
assess
occurrence
variability
wastes
potential
propagation
pathways
human
pathogens.
We
also
review
mechanisms
environmental
factors
influence
dissemination
through
pathways,
evaluate
ARG
removal
efficiency
common
management
approaches.
Challenges
research
needs
for
assessing
mitigating
risk
from
presented.
Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: July 12, 2021
Abstract
Cancer
development
and
its
response
to
therapy
are
regulated
by
inflammation,
which
either
promotes
or
suppresses
tumor
progression,
potentially
displaying
opposing
effects
on
therapeutic
outcomes.
Chronic
inflammation
facilitates
progression
treatment
resistance,
whereas
induction
of
acute
inflammatory
reactions
often
stimulates
the
maturation
dendritic
cells
(DCs)
antigen
presentation,
leading
anti-tumor
immune
responses.
In
addition,
multiple
signaling
pathways,
such
as
nuclear
factor
kappa
B
(NF-kB),
Janus
kinase/signal
transducers
activators
transcription
(JAK-STAT),
toll-like
receptor
(TLR)
cGAS/STING,
mitogen-activated
protein
kinase
(MAPK);
factors,
including
cytokines
(e.g.,
interleukin
(IL),
interferon
(IFN),
necrosis
(TNF)-α),
chemokines
C-C
motif
chemokine
ligands
(CCLs)
C-X-C
(CXCLs)),
growth
factors
vascular
endothelial
(VEGF),
transforming
(TGF)-β),
inflammasome;
well
metabolites
prostaglandins,
leukotrienes,
thromboxane,
specialized
proresolving
mediators
(SPM),
have
been
identified
pivotal
regulators
initiation
resolution
inflammation.
Nowadays,
local
irradiation,
recombinant
cytokines,
neutralizing
antibodies,
small-molecule
inhibitors,
DC
vaccines,
oncolytic
viruses,
TLR
agonists,
SPM
developed
specifically
modulate
in
cancer
therapy,
with
some
these
already
undergoing
clinical
trials.
Herein,
we
discuss
crosstalk
between
processes.
We
also
highlight
potential
targets
for
harnessing
cancer.
Physiological Reviews,
Journal Year:
2019,
Volume and Issue:
99(3), P. 1325 - 1380
Published: March 28, 2019
Sleep
and
immunity
are
bidirectionally
linked.
Immune
system
activation
alters
sleep,
sleep
in
turn
affects
the
innate
adaptive
arm
of
our
body’s
defense
system.
Stimulation
immune
by
microbial
challenges
triggers
an
inflammatory
response,
which,
depending
on
its
magnitude
time
course,
can
induce
increase
duration
intensity,
but
also
a
disruption
sleep.
Enhancement
during
infection
is
assumed
to
feedback
promote
host
defense.
Indeed,
various
parameters,
associated
with
reduced
risk,
improve
outcome
vaccination
responses.
The
induction
hormonal
constellation
that
supports
functions
one
likely
mechanism
underlying
immune-supporting
effects
In
absence
infectious
challenge,
appears
homeostasis
through
several
mediators,
such
as
cytokines.
This
notion
supported
findings
prolonged
deficiency
(e.g.,
short
duration,
disturbance)
lead
chronic,
systemic
low-grade
inflammation
diseases
have
component,
like
diabetes,
atherosclerosis,
neurodegeneration.
Here,
we
review
available
data
this
regulatory
sleep-immune
crosstalk,
point
out
methodological
challenges,
suggest
questions
open
for
future
research.
Journal for ImmunoTherapy of Cancer,
Journal Year:
2020,
Volume and Issue:
8(1), P. e000337 - e000337
Published: March 1, 2020
Cells
succumbing
to
stress
via
regulated
cell
death
(RCD)
can
initiate
an
adaptive
immune
response
associated
with
immunological
memory,
provided
they
display
sufficient
antigenicity
and
adjuvanticity.
Moreover,
multiple
intracellular
microenvironmental
features
determine
the
propensity
of
RCD
drive
immunity.
Here,
we
provide
updated
operational
definition
immunogenic
(ICD),
discuss
key
factors
that
dictate
ability
dying
cells
response,
summarize
experimental
assays
are
currently
available
for
assessment
ICD
in
vitro
vivo,
formulate
guidelines
their
interpretation.
Advanced Materials,
Journal Year:
2018,
Volume and Issue:
30(29)
Published: May 7, 2018
Abstract
Advances
in
biomaterials
for
drug
delivery
are
enabling
significant
progress
biology
and
medicine.
Multidisciplinary
collaborations
between
physical
scientists,
engineers,
biologists,
clinicians
generate
innovative
strategies
materials
to
treat
a
range
of
diseases.
Specifically,
recent
advances
include
major
breakthroughs
cancer
immunotherapy,
autoimmune
diseases,
genome
editing.
Here,
the
design
implementation
reviewed.
A
brief
history
field
is
first
established,
then
commentary
on
RNA
delivery,
responsive
development,
immunomodulation
provided.
Current
challenges
associated
with
these
areas
as
well
opportunities
address
long‐standing
problems
medicine
discussed
throughout.
Journal of Clinical Investigation,
Journal Year:
2015,
Volume and Issue:
125(9), P. 3347 - 3355
Published: Aug. 31, 2015
Cancer
development
and
its
response
to
therapy
are
strongly
influenced
by
innate
adaptive
immunity,
which
either
promote
or
attenuate
tumorigenesis
can
have
opposing
effects
on
therapeutic
outcome.
Chronic
inflammation
promotes
tumor
development,
progression,
metastatic
dissemination,
as
well
treatment
resistance.
However,
cancer
malignant
progression
also
associated
with
accumulation
of
genetic
alterations
loss
normal
regulatory
processes,
cause
expression
tumor-specific
antigens
tumor-associated
(TAAs)
that
activate
antitumor
immune
responses.
Although
signals
trigger
acute
inflammatory
reactions
often
stimulate
dendritic
cell
maturation
antigen
presentation,
chronic
be
immunosuppressive.
This
antagonism
between
immunity
affects
the
outcome
needs
considered
when
designing
new
approaches.
Gut,
Journal Year:
2017,
Volume and Issue:
66(3), P. 541 - 553
Published: Jan. 4, 2017
Acute-on-chronic
liver
failure
(ACLF)
is
a
syndrome
characterised
by
acute
decompensation
of
chronic
disease
associated
with
organ
failures
and
high
short-term
mortality.
Alcohol
viral
hepatitis
are
the
most
common
underlying
diseases.
Up
to
40%–50%
cases
ACLF
have
no
identifiable
trigger;
in
remaining
patients,
sepsis,
active
alcoholism
relapse
reported
precipitating
factors.
An
excessive
systemic
inflammatory
response
seems
play
crucial
role
development
ACLF.
Using
liver-adapted
sequential
assessment
score,
it
possible
triage
prognosticate
outcome
patients
The
course
dynamic
changes
over
hospital
admission.
Most
will
clear
prognosis
between
day
3
7
admission
clinical
decisions
such
as
evaluation
for
transplant
or
discussion
goals
care
could
be
tailored
using
scores.
Bioartificial
support
systems,
granulocyte-colony
stimulating
factors
stem-cell
horizon
medical
this
patient
population;
however,
data
too
premature
implement
them
standard
care.
