Evolution and Diversity of Immune Responses during Acute HIV Infection DOI Creative Commons
Samuel W. Kazer, Bruce D. Walker, Alex K. Shalek

et al.

Immunity, Journal Year: 2020, Volume and Issue: 53(5), P. 908 - 924

Published: Nov. 1, 2020

Understanding the earliest immune responses following HIV infection is critical to inform future vaccines and therapeutics. Here, we review recent prospective human studies in at-risk populations that have provided insight into during acute infection, including additional relevant data from non-human primate (NHP) studies. We discuss timing, nature, function of diverse induced, onset dysfunction, effects early anti-retroviral therapy administration. Treatment at viremia mitigates peripheral T B cell limits seroconversion, enhances cellular antiviral immunity despite persistence lymphoid tissues. highlight pertinent areas for investigation, how application high-throughput technologies, alongside targeted NHP studies, may elucidate response features target novel preventions cures.

Language: Английский

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors DOI
Étienne Patin, Milena Hasan, Jacob Bergstedt

et al.

Nature Immunology, Journal Year: 2018, Volume and Issue: 19(3), P. 302 - 314

Published: Feb. 20, 2018

Language: Английский

Citations

260
Infectious immunity in the central nervous system and brain function DOI
Robyn S. Klein, Charise Garber,

Nicole C. Howard

et al.

Nature Immunology, Journal Year: 2017, Volume and Issue: 18(2), P. 132 - 141

Published: Jan. 16, 2017

Language: Английский

Citations

196
Immunomodulation—a general review of the current state-of-the-art and new therapeutic strategies for targeting the immune system DOI Creative Commons
Martyna Strzelec, Jan Detka,

Patrycja Mieszczak

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: March 9, 2023

In recent years, there has been a tremendous development of biotechnological, pharmacological, and medical techniques which can be implemented in the functional modulation immune system components. Immunomodulation attracted much attention because it offers direct applications both basic research clinical therapy. Modulation non-adequate, amplified response enables to attenuate course disease restore homeostasis. The potential targets modulate immunity are as multiple components system, thus creating various possibilities for intervention. However, immunomodulation faces new challenges design safer more efficacious therapeutic compounds. This review cross-sectional picture currently used newest pharmacological interventions, genomic editing, tools regenerative medicine involving immunomodulation. We reviewed available experimental evidence prove efficiency, safety, feasibility vitro vivo. also advantages limitations described techniques. Despite its limitations, is considered therapy itself or an adjunct with promising results developing potential.

Language: Английский

Citations

84
Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness DOI Open Access

Shilpa S. Iyer,

Frédéric Bibollet‐Ruche,

Scott Sherrill-Mix

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2017, Volume and Issue: 114(4)

Published: Jan. 9, 2017

Significance Effective prevention strategies are urgently needed to control the spread of HIV-1. A critical barrier developing such is lack understanding host antiviral defenses that HIV-1 replication in mucosa at site entry. Here, we characterized viruses from matched donor and recipient pairs determine whether transmitted strains exhibit traits increase their transmission fitness. Characterizing 300 limiting dilution-derived isolates, identified several properties enhance virus face a vigorous innate immune response, which resistance type 1 IFNs most important. These results provide new insights into process define possible targets for AIDS therapy.

Language: Английский

Citations

139
NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses DOI Creative Commons
Haitao Guo, Renate König, Meng Deng

et al.

Cell Host & Microbe, Journal Year: 2016, Volume and Issue: 19(4), P. 515 - 528

Published: April 1, 2016

Language: Английский

Citations

138
SLFN 11 inhibits checkpoint maintenance and homologous recombination repair DOI

Yanhua Mu,

Jiangman Lou,

Mrinal Srivastava

et al.

EMBO Reports, Journal Year: 2015, Volume and Issue: 17(1), P. 94 - 109

Published: Dec. 9, 2015

Language: Английский

Citations

131
Dopaminergic Regulation of Innate Immunity: a Review DOI
Monica Pinoli, Franca Marino, Marco Cosentino

et al.

Journal of Neuroimmune Pharmacology, Journal Year: 2017, Volume and Issue: 12(4), P. 602 - 623

Published: June 3, 2017

Language: Английский

Citations

123
Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids DOI Creative Commons
Yen-Li Li, Viswanathan Chandrasekaran, Stephen D. Carter

et al.

eLife, Journal Year: 2016, Volume and Issue: 5

Published: June 2, 2016

TRIM5 proteins are restriction factors that block retroviral infections by binding viral capsids and preventing reverse transcription. Capsid recognition is mediated C-terminal domains on TRIM5α (SPRY) or TRIMCyp (cyclophilin A), which interact weakly with capsids. Efficient capsid also requires the conserved N-terminal tripartite motifs (TRIM), mediate oligomerization create avidity effects. To characterize how recognize capsids, we developed methods for isolating native recombinant purifying stable HIV-1 Biochemical EM analyses revealed assembled into hexagonal nets, both alone surfaces. These nets comprised open hexameric rings, SPRY centered edges B-box RING at vertices. Thus, principles of assembly pattern across primates, allowing assemblies to maintain conformational plasticity necessary divergent pleomorphic

Language: Английский

Citations

103
Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted antiviral functions of APOBEC3G DOI
Darja Pollpeter, Maddy Parsons,

Andrew Sobala

et al.

Nature Microbiology, Journal Year: 2017, Volume and Issue: 3(2), P. 220 - 233

Published: Nov. 17, 2017

Language: Английский

Citations

99
Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures DOI Creative Commons
Andrea Imle,

Peter Kumberger,

Nikolas D. Schnellbächer

et al.

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: May 13, 2019

Abstract Pathogens face varying microenvironments in vivo, but suitable experimental systems and analysis tools to dissect how three-dimensional (3D) tissue environments impact pathogen spread are lacking. Here we develop an Integrative method Study Pathogen by Experiment Computation within Tissue-like 3D cultures (INSPECT-3D), combining quantification of replication with imaging study single-cell cell population dynamics. We apply INSPECT-3D analyze HIV-1 between primary human CD4 T-lymphocytes using collagen as tissue-like 3D-scaffold. Measurements virus replication, infectivity, diffusion, cellular motility interactions combined mathematical analyses into integrated spatial infection model estimate parameters governing spread. This reveals that environmental restrictions limit cell-free virions promote cell-associated transmission. Experimental validation identifies density essential determinants efficacy mode 3D. represents adaptable for quantitative time-resolved

Language: Английский

Citations

80