Single-cell RNA sequencing to explore immune cell heterogeneity

Nature reviews. Immunology, Journal Year: 2017, Volume and Issue: 18(1), P. 35 - 45

Published: Aug. 7, 2017

Language: Английский

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Dictionary learning for integrative, multimodal and scalable single-cell analysis

Nature Biotechnology, Journal Year: 2023, Volume and Issue: 42(2), P. 293 - 304

Published: May 25, 2023

Language: Английский

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Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy

Cell, Journal Year: 2019, Volume and Issue: 178(6), P. 1493 - 1508.e20

Published: Aug. 29, 2019

Language: Английский

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The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

Nature, Journal Year: 2017, Volume and Issue: 549(7672), P. 351 - 356

Published: Sept. 12, 2017

Language: Английский

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Tumour heterogeneity and metastasis at single-cell resolution

Nature Cell Biology, Journal Year: 2018, Volume and Issue: 20(12), P. 1349 - 1360

Published: Nov. 19, 2018

Language: Английский

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The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome

Cell, Journal Year: 2016, Volume and Issue: 166(5), P. 1231 - 1246.e13

Published: Aug. 1, 2016

Language: Английский

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Single-cell transcriptomics to explore the immune system in health and disease

Science, Journal Year: 2017, Volume and Issue: 358(6359), P. 58 - 63

Published: Oct. 5, 2017

The immune system varies in cell types, states, and locations. complex networks, interactions, responses of cells produce diverse cellular ecosystems composed multiple accompanied by genetic diversity antigen receptors. Within this ecosystem, innate adaptive maintain protect tissue function, integrity, homeostasis upon changes functional demands insults. Characterizing inherent complexity requires studies at single-cell resolution. Recent advances such as massively parallel RNA sequencing sophisticated computational methods are catalyzing a revolution our understanding immunology. Here we provide an overview the state genomics outlook on use techniques to decipher components immunity.

Language: Английский

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Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity

Cell, Journal Year: 2019, Volume and Issue: 179(4), P. 846 - 863.e24

Published: Oct. 1, 2019

Dendritic cells (DCs) play a critical role in orchestrating adaptive immune responses due to their unique ability initiate T cell and direct differentiation into effector lineages. Classical DCs have been divided two subsets, cDC1 cDC2, based on phenotypic markers distinct abilities prime CD8 CD4 cells. While the transcriptional regulation of subset has well characterized, cDC2 development function remain poorly understood. By combining chromatin analyses with genetic reporter expression, we identified principal lineages defined by developmental pathways regulators, including T-bet RORγt, key transcription factors known define innate lymphocyte subsets. These novel were characterized metabolic functional programs. Extending our findings humans revealed conserved DC heterogeneity presence newly subsets human cancer.

Language: Английский

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NK cells and type 1 innate lymphoid cells: partners in host defense

Nature Immunology, Journal Year: 2016, Volume and Issue: 17(7), P. 758 - 764

Published: June 21, 2016

Language: Английский

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High-Dimensional Single-Cell Analysis Identifies Organ-Specific Signatures and Conserved NK Cell Subsets in Humans and Mice

Immunity, Journal Year: 2018, Volume and Issue: 49(5), P. 971 - 986.e5

Published: Nov. 1, 2018

Natural killer (NK) cells are innate lymphoid (ILCs) involved in antimicrobial and antitumoral responses. Several NK cell subsets have been reported humans mice, but their heterogeneity across organs species remains poorly characterized. We assessed the diversity of human mouse by single-cell RNA sequencing on thousands individual isolated from spleen blood. Unbiased transcriptional clustering revealed two distinct signatures differentiating between splenic blood cells. This analysis at resolution identified three subpopulations four spleen, each A comparison transcriptomic profiles within highlighted similarity major subsets, NK1 NK2, species. unbiased approach provides insight into biology establishes a rationale for translation studies to physiology disease.

Language: Английский

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