Cell Research,
Journal Year:
2020,
Volume and Issue:
30(6), P. 475 - 491
Published: May 6, 2020
Abstract
The
multifaceted
organization
of
the
immune
system
involves
not
only
patrolling
lymphocytes
that
constantly
monitor
antigen-presenting
cells
in
secondary
lymphoid
organs
but
also
establish
permanent
tissue-residency.
integration
respective
tissue
and
adaption
to
organ
milieu
enable
tissue-resident
signaling
circuits
with
parenchymal
coordinate
responses
maintain
homeostasis.
Innate
(ILCs)
are
innate
have
a
similar
functional
diversity
T
including
lineage-specifying
transcription
factors
drive
certain
effector
programs.
Since
their
formal
discovery
10
years
ago,
it
has
become
clear
ILCs
present
almost
every
strongly
enriched
at
barrier
surfaces,
where
they
regulate
immunity
infection,
chronic
inflammation,
maintenance.
In
this
context,
recent
research
identified
as
key
orchestrating
homeostasis
through
ability
sustain
bidirectional
interactions
epithelial
cells,
neurons,
stromal
adipocytes,
many
other
cells.
review,
we
provide
comprehensive
discussion
studies
define
development
heterogeneity
ILC
populations
impact
on
adaptive
immunity.
Further,
discuss
emerging
influence
nervous
system,
circadian
rhythm,
developmental
plasticity
function.
Uncovering
control
function
will
an
integrated
view
how
tissues
synchronized
relevance
far
beyond
classical
role
discrimination
between
self/non-self
host
defense.
Frontiers in Immunology,
Journal Year:
2019,
Volume and Issue:
10
Published: May 7, 2019
Innate
lymphoid
cells
(ILCs)
are
innate
counterpart
of
T
that
contribute
to
immune
responses
by
secreting
effector
cytokines
and
regulating
the
functions
other
adaptive
cells.
ILCs
carry
out
some
unique
but
share
tasks
with
present
in
non-lymphoid
organs,
particularly
abundant
at
mucosal
barriers,
where
they
exposed
allergens,
commensal
microbes
pathogens.
The
impact
has
been
extensively
investigated
gastrointestinal
respiratory
tracts,
as
well
oral
cavity.
Here
we
review
state-of-the-art
knowledge
ILC
infections,
allergy
autoimmune
disorders
barriers.
Immunological Reviews,
Journal Year:
2018,
Volume and Issue:
286(1), P. 37 - 52
Published: Oct. 7, 2018
Summary
Group
2
innate
lymphoid
cells
(
ILC
2s)
play
critical
roles
in
the
induction
of
type
inflammation,
response
to
parasite
infection,
metabolic
homeostasis,
and
tissue
repair.
These
multifunctional
2s
are
tightly
controlled
by
complex
regulatory
systems
local
microenvironment,
disruption
which
may
cause
various
health
problems.
This
review
summarizes
up‐to‐date
knowledge
regarding
positive
negative
regulators
for
based
on
their
function
signaling
pathways,
including
activating
cytokines
IL
‐33,
‐25;
MAPK
,
NF
‐κB
pathways),
co‐stimulatory
‐2,
‐7,
‐9,
TSLP
;
STAT
5,
‐4;
6,
TNF
superfamily;
suppressive
(type1
IFN
s,
‐γ,
‐27;
1,
‐10,
TGF
‐β),
transdifferentiation
‐12;
4,
‐1β,
‐18),
lipid
mediators
LTC
LTD
LTE
PGD
2;
Ca
2+
‐
NFAT
PGE
2,
PGI
AC
/
cAMP
PKA
LXA
LTB
4),
neuropeptides
NMU
VIP
CGRP
catecholamine,
acetylcholine),
sex
hormones
(androgen,
estrogen),
nutrients
(butyrate;
HDAC
inhibitors,
vitamins),
cell‐to‐cell
interactions
ICOSL
ICOS
B7‐H6‐
NK
p30,
E‐cadherin‐
KLRG
1).
comprehensive
affords
a
better
understanding
network
system
2s,
providing
impetus
develop
new
treatment
strategies
2‐related
Journal of Allergy and Clinical Immunology,
Journal Year:
2016,
Volume and Issue:
138(5), P. 1253 - 1264
Published: Nov. 1, 2016
In
the
last
decade,
full
picture
of
role
innate
lymphoid
cells
(ILCs)
has
been
gradually
revealed.
ILCs
are
classified
into
3
groups
based
on
their
transcription
factors
and
cytokine
production
patterns,
which
mirror
helper
T-cell
subsets.
Unlike
T
B
cells,
do
not
have
antigen
receptors.
They
promptly
respond
to
multiple
tissue-derived
factors,
such
as
cytokines
alarmins,
produce
proinflammatory
immunoregulatory
cytokines.
It
reported
that
ILC-derived
important
for
induction
regulation
inflammation.
Accumulating
evidence
suggests
play
substantial
roles
in
protection
against
infection
pathogenesis
inflammatory
diseases,
allergic
diseases
autoimmune
diseases.
Different
ILC
subsets
localize
distinct
tissue/organ
niches
receive
signals
different
types
inflammation,
allows
them
acquire
diverse
phenotypes
with
specialized
effector
capacities.
this
review
we
highlight
a
variety
organs,
airway,
skin,
gastrointestinal
tract,
context
nonallergic
