The Atlas of Inflammation Resolution (AIR) DOI Creative Commons
Charles N. Serhan, Shailendra K. Gupta, Mauro Perretti

et al.

Molecular Aspects of Medicine, Journal Year: 2020, Volume and Issue: 74, P. 100894 - 100894

Published: Aug. 1, 2020

Acute inflammation is a protective reaction by the immune system in response to invading pathogens or tissue damage. Ideally, should be localized, self-limited, and returning homeostasis. If not resolved, acute can result organ pathologies leading chronic inflammatory phenotypes. resolution are complex coordinated processes, involving number of cell types, interacting space time. The biomolecular complexity fact that several biomedical fields involved, make multi- interdisciplinary approach necessary. Atlas Inflammation Resolution (AIR) web-based resource capturing an essential part state-of-the-art research. AIR provides interface for users search thousands interactions, arranged inter-connected multi-layers process diagrams, covering wide range clinically relevant By mapping experimental data onto AIR, it used elucidate drug action as well molecular mechanisms underlying different disease For visualization exploration information, uses Minerva platform, which well-established tool presentation maps. details encoded using international standards. was created freely accessible resource, supporting research education resolution. connects communities, facilitates clinical decision making, supports scientists formulation validation hypotheses. through https://air.bio.informatik.uni-rostock.de

Language: Английский

Chronic inflammation in the etiology of disease across the life span DOI Open Access
David Furman, Judith Campisi, Eric Verdin

et al.

Nature Medicine, Journal Year: 2019, Volume and Issue: 25(12), P. 1822 - 1832

Published: Dec. 1, 2019

Language: Английский

Citations

3455
Diversity, Mechanisms, and Significance of Macrophage Plasticity DOI
Massimo Locati, Graziella Curtale, Alberto Mantovani

et al.

Annual Review of Pathology Mechanisms of Disease, Journal Year: 2019, Volume and Issue: 15(1), P. 123 - 147

Published: Sept. 18, 2019

Macrophages are a diverse set of cells present in all body compartments. This diversity is imprinted by their ontogenetic origin (embryonal versus adult bone marrow-derived cells); the organ context; activation or deactivation various signals contexts microbial invasion, tissue damage, and metabolic derangement; polarization adaptive T cell responses. Classic responses macrophages include tolerance, priming, wide spectrum states, including M1, M2, M2-like. Moreover, can retain long-term imprinting encounters (trained innate immunity). Single-cell analysis mononuclear phagocytes health disease has added new dimension to our understanding macrophage differentiation activation. Epigenetic landscapes, transcription factors, microRNA networks underlie adaptability different environmental cues. Macrophage plasticity, an essential component chronic inflammation, its involvement human diseases, most notably cancer, discussed here as paradigm.

Language: Английский

Citations

1523
The intestinal microbiota fuelling metabolic inflammation DOI
Herbert Tilg, Niv Zmora, Timon E. Adolph

et al.

Nature reviews. Immunology, Journal Year: 2019, Volume and Issue: 20(1), P. 40 - 54

Published: Aug. 6, 2019

Language: Английский

Citations

806
Innate immune responses to trauma DOI
Markus Huber‐Lang, John D. Lambris, Peter A. Ward

et al.

Nature Immunology, Journal Year: 2018, Volume and Issue: 19(4), P. 327 - 341

Published: March 5, 2018

Language: Английский

Citations

480
Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host’s Response to Pathogens DOI Creative Commons

Mihai G. Netea,

Andreas Schlitzer, Katarzyna Placek

et al.

Cell Host & Microbe, Journal Year: 2019, Volume and Issue: 25(1), P. 13 - 26

Published: Jan. 1, 2019

Language: Английский

Citations

475
Potential Role of Flavonoids in Treating Chronic Inflammatory Diseases with a Special Focus on the Anti-Inflammatory Activity of Apigenin DOI Creative Commons
Rashida Ginwala,

Raina Bhavsar,

DeGaulle I. Chigbu

et al.

Antioxidants, Journal Year: 2019, Volume and Issue: 8(2), P. 35 - 35

Published: Feb. 5, 2019

Inflammation has been reported to be intimately linked the development or worsening of several non-infectious diseases. A number chronic conditions such as cancer, diabetes, cardiovascular disorders, autoimmune diseases, and neurodegenerative disorders emerge a result tissue injury genomic changes induced by constant low-grade inflammation in around affected organ. The existing therapies for most these sometimes leave more debilitating effects than disease itself, warranting advent safer, less toxic, cost-effective therapeutic alternatives patients. For centuries, flavonoids their preparations have used treat various human illnesses, continual use persevered throughout ages. This review focuses on anti-inflammatory actions against illnesses neuroinflammation with special focus apigenin, relatively toxic non-mutagenic flavonoid remarkable pharmacodynamics. Additionally, central nervous system (CNS) due diseases multiple sclerosis (MS) gives ready access circulating lymphocytes, monocytes/macrophages, dendritic cells (DCs), causing edema, further inflammation, demyelination. As dearth safe is dire case CNS-related we reviewed neuroprotective apigenin other flavonoids. Existing epidemiological pre-clinical studies present considerable evidence favor developing natural alternative therapy inflammatory conditions.

Language: Английский

Citations

470
Genetic and biological hallmarks of colorectal cancer DOI Open Access
Jiexi Li, Xingdi Ma, Deepavali Chakravarti

et al.

Genes & Development, Journal Year: 2021, Volume and Issue: 35(11-12), P. 787 - 820

Published: June 1, 2021

Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid tumors, these insights have illuminated early detection, risk stratification, prevention, treatment principles. Employing hallmarks framework, we provide conceptual framework to understand how alterations in colorectal drive cell biology properties shape heterotypic interactions across cells tumor microenvironment. This review details research advances pertaining genetics cancer, emerging concepts gleaned from immune single-cell profiling, critical remaining knowledge gaps influencing development effective therapies this that remains major public health burden.

Language: Английский

Citations

376
Resolution of chronic inflammatory disease: universal and tissue-specific concepts DOI Creative Commons
Georg Schett, Markus F. Neurath

Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)

Published: Aug. 9, 2018

Inflammation and its resolution is under-studied in medicine despite being essential for understanding the development of chronic inflammatory disease. In this review article, we discuss inflammation both a biological translational context. We introduce concept impaired leading to diseases like rheumatoid arthritis, Crohn's disease, asthma, as well cellular molecular components that contribute joint, gut, lung inflammation, respectively. Finally, potential intervention strategies fostering process, their implications therapy diseases.

Language: Английский

Citations

352
IL‐1 and IL‐1 regulatory pathways in cancer progression and therapy DOI
Alberto Mantovani, Isabella Barajon, Cecília Garlanda

et al.

Immunological Reviews, Journal Year: 2017, Volume and Issue: 281(1), P. 57 - 61

Published: Dec. 16, 2017

Summary Inflammation is an important component of the tumor microenvironment. IL ‐1 inflammatory cytokine which plays a key role in carcinogenesis and progression. subject to regulation by components receptor ( ILR ) families. Negative regulators include decoy ‐1R2), antagonists ‐1Ra), ‐1R8, anti‐inflammatory ‐37. acts at different levels initiation progression, including driving chronic non‐resolving inflammation, angiogenesis, activation ‐17 pathway, induction myeloid‐derived suppressor cells MDSC macrophage recruitment, invasion metastasis. Based on initial clinical results, translation potential targeting deserves extensive analysis.

Language: Английский

Citations

331
Calprotectin: from biomarker to biological function DOI Creative Commons
A Jukic, Latifa Bakiri, Erwin F. Wagner

et al.

Gut, Journal Year: 2021, Volume and Issue: 70(10), P. 1978 - 1988

Published: June 18, 2021

The incidence of inflammatory bowel diseases (IBD) emerged with Westernisation dietary habits worldwide. Crohn's disease and ulcerative colitis are chronic debilitating conditions that afflict individuals substantial morbidity challenge healthcare systems across the globe. Since identification characterisation calprotectin (CP) in 1980s, faecal CP as significantly validated, non-invasive biomarker allows evaluation gut inflammation. Faecal discriminates between non-inflammatory portraits course human IBD. Recent studies revealed insights into biological functions subunits S100A8 S100A9 during orchestration an response at mucosal surfaces organ systems. In this review, we summarise longitudinal evidence for evolution from to rheostat inflammation suggest algorithm interpretation daily clinical practice. We propose mechanistic function beyond may facilitate current assays guide patient-tailored medical therapy IBD, a concept warranting controlled trials.

Language: Английский

Citations

320