Handbook of Religion and Health

Oxford University Press eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 23, 2023

Abstract The 2001 (first) edition of this Handbook was a comprehensive review history, research, and discussions on religion health through the year 2000. Appendix listed 1,200 separate quantitative studies each rated in quality 0–10 scale, followed by about 2,000 references an extensive index for rapid topic identification. 2012 (second) systematically updated research from 2000 to 2010, with number then reaching thousands. This 2023 (third) is most scientifically rigorous date, covering best published 2021 emphasis prospective randomized controlled trials. Beginning Foreword Dr. Howard K. Koh, former US Assistant Secretary Health Department Human Services, nearly 600,000-word volume examines almost every aspect health, reviewing past more recent relationship between outcomes. Furthermore, all its 34 chapters conclude clinical community applications, making text relevant both healthcare professionals (physicians, nurses, social workers, rehabilitation therapists, counselors, psychologists, sociologists, etc.) clergy (community clergy, chaplains, pastoral etc.). book’s focuses studies, describing study single line, allowing researchers quickly locate existing research. It should not be surprising that two decades has been cited health.

Language: Английский

---

NAD+ metabolism and its roles in cellular processes during ageing

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 22(2), P. 119 - 141

Published: Dec. 22, 2020

Language: Английский

---

Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19

Cell, Journal Year: 2020, Volume and Issue: 182(6), P. 1401 - 1418.e18

Published: Aug. 5, 2020

Language: Английский

---

Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021

Nutrients, Journal Year: 2021, Volume and Issue: 13(7), P. 2421 - 2421

Published: July 15, 2021

Oxidative stress and inflammation have been recognized as important contributors to the risk of chronic non-communicable diseases. Polyunsaturated fatty acids (PUFAs) may regulate antioxidant signaling pathway modulate inflammatory processes. They also influence hepatic lipid metabolism physiological responses other organs, including heart. Longitudinal prospective cohort studies demonstrate that there is an association between moderate intake omega-6 PUFA linoleic acid lower cardiovascular diseases (CVDs), most likely a result blood cholesterol concentration. Current evidence suggests increasing arachidonic (up 1500 mg/day) has no adverse effect on platelet aggregation clotting, immune function markers inflammation, but benefit muscle cognitive performance. Many show higher intakes omega-3 PUFAs, especially eicosapentaenoic (EPA) docosahexaenoic (DHA), are associated with incidence characterized by elevated CVDs. This because multiple molecular cellular actions EPA DHA. Intervention trials using + DHA indicate CVD mortality significant inverse linear dose-response relationship found outcomes. In addition their anti-inflammatory roles, considered homeostasis thrombosis, which together potential use in COVID-19 therapy.

Language: Английский

---

Mental health and clinical psychological science in the time of COVID-19: Challenges, opportunities, and a call to action.

American Psychologist, Journal Year: 2020, Volume and Issue: 76(3), P. 409 - 426

Published: Aug. 10, 2020

COVID-19 presents significant social, economic, and medical challenges. Because has already begun to precipitate huge increases in mental health problems, clinical psychological science must assert a leadership role guiding national response this secondary crisis. In article, is conceptualized as unique, compounding, multidimensional stressor that will create vast need for intervention necessitate new paradigms service delivery training. Urgent challenge areas across developmental periods are discussed, followed by review of symptoms likely increase prevalence require innovative solutions both practice. Implications research directions, approaches, policy issues discussed highlight the opportunities emerge an updated, contemporary field capable addressing burden illness distress wake beyond. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Language: Английский

---

Role of Glutathione in Cancer: From Mechanisms to Therapies

Biomolecules, Journal Year: 2020, Volume and Issue: 10(10), P. 1429 - 1429

Published: Oct. 9, 2020

Glutathione (GSH) is the most abundant non-protein thiol present at millimolar concentrations in mammalian tissues. As an important intracellular antioxidant, it acts as a regulator of cellular redox state protecting cells from damage caused by lipid peroxides, reactive oxygen and nitrogen species, xenobiotics. Recent studies have highlighted importance GSH key signal transduction reactions controller cell differentiation, proliferation, apoptosis, ferroptosis immune function. Molecular changes antioxidant system disturbances homeostasis been implicated tumor initiation, progression, treatment response. Hence, has both protective pathogenic roles. Although healthy crucial for removal detoxification carcinogens, elevated levels are associated with progression increased resistance to chemotherapeutic drugs. Recently, several novel therapies developed target tumors means response decreased drug resistance. In this comprehensive review we explore mechanisms functionalities different therapeutic approaches that either directly, indirectly or use GSH-based prodrugs. Consideration also given computational methods used describe related processes silico testing effects.

Language: Английский

---

Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge

EClinicalMedicine, Journal Year: 2021, Volume and Issue: 31, P. 100683 - 100683

Published: Jan. 1, 2021

BackgroundThe medium-term effects of Coronavirus disease (COVID-19) on organ health, exercise capacity, cognition, quality life and mental health are poorly understood.MethodsFifty-eight COVID-19 patients post-hospital discharge 30 age, sex, body mass index comorbidity-matched controls were enrolled for multiorgan (brain, lungs, heart, liver kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary test (CPET), life, cognitive assessments.FindingsAt 2–3 months from disease-onset, 64% experienced breathlessness 55% reported fatigue. On MRI, abnormalities seen in lungs (60%), heart (26%), (10%) kidneys (29%). Patients exhibited changes the thalamus, posterior thalamic radiations sagittal stratum brain MRI demonstrated impaired performance, specifically executive visuospatial domains. Exercise tolerance (maximal oxygen consumption ventilatory efficiency CPET) distance significantly reduced. The extent extra-pulmonary intolerance correlated with serum markers inflammation acute illness severity. had a higher burden self-reported symptoms depression significant impairment all domains compared to (p<0.0001 0.044).InterpretationA proportion discharged hospital breathlessness, fatigue, limited capacity. Persistent lung findings common linked severity illness.FundingNIHR Oxford Health Biomedical Research Centres, British Heart Foundation Centre Excellence, UKRI, Wellcome Trust, Foundation.

Language: Английский

---

The Gut Microbiota and Inflammation: An Overview

International Journal of Environmental Research and Public Health, Journal Year: 2020, Volume and Issue: 17(20), P. 7618 - 7618

Published: Oct. 19, 2020

The gut microbiota encompasses a diverse community of bacteria that carry out various functions influencing the overall health host. These comprise nutrient metabolism, immune system regulation and natural defence against infection. presence certain is associated with inflammatory molecules may bring about inflammation in body tissues. Inflammation underlies many chronic multisystem conditions including obesity, atherosclerosis, type 2 diabetes mellitus bowel disease. be triggered by structural components which can result cascade pathways involving interleukins other cytokines. Similarly, by-products metabolic processes bacteria, some short-chain fatty acids, play role inhibiting processes. In this review, we aimed to provide an overview relationship between highlight relevant knowledge gaps field. Based on current literature, it appears as composition differs individuals contingent variety factors like diet genetics, possess pro-inflammatory effects whilst others harbour those anti-inflammatory effects. Recent technological advancements have allowed for better methods characterising microbiota. Further research continually improve our understanding interact elucidate reasons behind varying presentations same disease varied responses treatment different individuals. Furthermore, inform clinical practice microbes employed probiotic therapies or used identify suitable prebiotic therapies.

Language: Английский

---

Inflammation and aging: signaling pathways and intervention therapies

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: June 8, 2023

Abstract Aging is characterized by systemic chronic inflammation, which accompanied cellular senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the multidimensional complexity of aging, there an urgent need for a systematic organization inflammaging through dimensionality reduction. Factors secreted senescent cells, known as senescence-associated secretory phenotype (SASP), promote inflammation can induce senescence in normal cells. At same time, accelerates immune resulting weakened function inability to clear cells inflammatory factors, creates vicious cycle senescence. Persistently elevated levels organs such bone marrow, liver, lungs cannot be eliminated leading damage aging-related Therefore, has been recognized endogenous factor elimination could potential strategy anti-aging. Here we discuss at molecular, cellular, organ, disease levels, review current aging models, implications cutting-edge single cell technologies, well anti-aging strategies. Since preventing alleviating diseases improving overall quality life are ultimate goals research, our highlights critical features mechanisms along with latest developments future directions providing theoretical foundation novel practical

Language: Английский

---

Ultraprocessed food and chronic noncommunicable diseases: A systematic review and meta‐analysis of 43 observational studies

Obesity Reviews, Journal Year: 2020, Volume and Issue: 22(3)

Published: Nov. 9, 2020

This systematic review and meta-analysis investigated the association between consumption of ultraprocessed food noncommunicable disease risk, morbidity mortality. Forty-three observational studies were included (N = 891,723): 21 cross-sectional, 19 prospective, two case-control one conducted both a prospective cross-sectional analysis. Meta-analysis demonstrated was associated with increased risk overweight (odds ratio: 1.36; 95% confidence interval [CI], 1.23-1.51; P < 0.001), obesity 1.51; CI, 1.34-1.70; abdominal 1.49; 1.34-1.66; 0.0001), all-cause mortality (hazard 1.28; 1.11-1.48; metabolic syndrome 1.81; 1.12-2.93; 0.015) depression in adults 1.22; 1.16-1.28, 0.001) as well wheezing 1.40; 1.27-1.55; but not asthma adolescents 1.20; 0.99-1.46; 0.065). In addition, cardiometabolic diseases, frailty, irritable bowel syndrome, functional dyspepsia cancer (breast overall) while also being dyslipidaemia children. Although links some intermediate factors highlighted, further are required to more clearly define associations children adolescents. STUDY REGISTRATION: Prospero ID: CRD42020176752.

Language: Английский

---