New avenues for anti-epileptic drug discovery and development

Nature Reviews Drug Discovery, Journal Year: 2013, Volume and Issue: 12(10), P. 757 - 776

Published: Sept. 20, 2013

Language: Английский

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The Long Noncoding RNA CHRF Regulates Cardiac Hypertrophy by Targeting miR-489

Circulation Research, Journal Year: 2014, Volume and Issue: 114(9), P. 1377 - 1388

Published: Feb. 21, 2014

Sustained cardiac hypertrophy is often accompanied by maladaptive remodeling leading to decreased compliance and increased risk for heart failure. Maladaptive considered be a therapeutic target MicroRNAs (miRNAs) long noncoding RNAs (lncRNAs) have various biological functions been extensively investigated in past years.We identified miR-489 lncRNAs (cardiac related factor, CHRF) from hypertrophic cardiomyocytes. Here, we tested the hypothesis that CHRF can participate regulation of vivo vitro.A microarray was performed analyze miRNAs response angiotensin II treatment, found substantially reduced. Enforced expression cardiomyocytes transgenic overexpression both exhibited reduced on treatment. We myeloid differentiation primary gene 88 (Myd88) as mediate function hypertrophy. Knockdown Myd88 Myd88-knockout mice showed attenuated responses. Furthermore, explored molecular mechanism which regulated an lncRNA named acts endogenous sponge miR-489, downregulates levels. able directly bind regulate hypertrophy.Our present study reveals novel regulating model composed CHRF, Myd88. The modulation their levels may provide new approach tackling

Language: Английский

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Glutamatergic Mechanisms Associated with Seizures and Epilepsy

Cold Spring Harbor Perspectives in Medicine, Journal Year: 2015, Volume and Issue: 5(8), P. a022863 - a022863

Published: June 22, 2015

Epilepsy is broadly characterized by aberrant neuronal excitability. Glutamate the predominant excitatory neurotransmitter in adult mammalian brain; thus, much of past epilepsy research has attempted to understand role glutamate seizures and epilepsy. Seizures induce elevations extracellular glutamate, which then contribute excitotoxic damage. Chronic can alter glial expression receptors uptake transporters, further contributing epileptogenesis. Evidence points a shared pathology for other central nervous system (CNS) disorders, including depression, often comorbidity Therapies that target glutamatergic neurotransmission are available, but many have met with difficulty because untoward adverse effects. Better understanding this generated novel therapeutic targets directly indirectly modulate signaling. Thus, future efforts manage epileptic patient glutamatergic-centric treatments now hold greater potential.

Language: Английский

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Adult-specific functions of animal microRNAs

Nature Reviews Genetics, Journal Year: 2013, Volume and Issue: 14(8), P. 535 - 548

Published: July 2, 2013

Language: Английский

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MicroRNAs Shape the Neuronal Landscape

Neuron, Journal Year: 2012, Volume and Issue: 75(3), P. 363 - 379

Published: Aug. 1, 2012

Language: Английский

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MicroRNAs in neural development: from master regulators to fine-tuners

Development, Journal Year: 2017, Volume and Issue: 144(13), P. 2310 - 2322

Published: July 1, 2017

The proper formation and function of neuronal networks is required for cognition behavior. Indeed, pathophysiological states that disrupt can lead to neurodevelopmental disorders such as autism, schizophrenia or intellectual disability. It well-established transcriptional programs play major roles in neural circuit development. However, recent years, post-transcriptional control gene expression has emerged an additional, probably equally important, regulatory layer. In particular, it been shown microRNAs (miRNAs), abundant class small RNAs, regulate development, maturation by controlling, example, local mRNA translation. also becoming clear miRNAs are frequently dysregulated disorders, suggesting a role the etiology and/or maintenance neurological disease states. Here, we provide overview most prominent highlighting how they act ‘master regulators’ ‘fine-tuners’ expression, depending on context, influence processes cell fate determination, migration, polarization synapse formation.

Language: Английский

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MicroRNAs in epilepsy: pathophysiology and clinical utility

The Lancet Neurology, Journal Year: 2016, Volume and Issue: 15(13), P. 1368 - 1376

Published: Nov. 8, 2016

Language: Английский

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The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873

Cell Death and Differentiation, Journal Year: 2016, Volume and Issue: 23(8), P. 1394 - 1405

Published: June 3, 2016

Language: Английский

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Transient Inhibition of TrkB Kinase after Status Epilepticus Prevents Development of Temporal Lobe Epilepsy

Neuron, Journal Year: 2013, Volume and Issue: 79(1), P. 31 - 38

Published: June 20, 2013

Language: Английский

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Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy

Neurobiology of Disease, Journal Year: 2016, Volume and Issue: 99, P. 12 - 23

Published: Dec. 9, 2016

Language: Английский

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