Cell Death Discovery,
Journal Year:
2021,
Volume and Issue:
7(1)
Published: April 7, 2021
Abstract
Ovarian
cancer
(OC)
is
a
highly
malignant
gynaecological
tumour
that
has
very
poor
prognosis.
Pyroptosis
been
demonstrated
in
recent
years
to
be
an
inflammatory
form
of
programmed
cell
death.
However,
the
expression
pyroptosis-related
genes
OC
and
their
correlations
with
prognosis
remain
unclear.
In
this
study,
we
identified
31
pyroptosis
regulators
were
differentially
expressed
between
normal
ovarian
tissues.
Based
on
these
(DEGs),
all
cases
could
divided
into
two
subtypes.
The
prognostic
value
each
gene
for
survival
was
evaluated
construct
multigene
signature
using
Cancer
Genome
Atlas
(TCGA)
cohort.
By
applying
least
absolute
shrinkage
selection
operator
(LASSO)
Cox
regression
method,
7-gene
built
classified
patients
TCGA
cohort
low-
or
high-risk
group.
low-risk
group
showed
significantly
higher
possibilities
than
those
(
P
<
0.001).
Utilizing
median
risk
score
from
cohort,
Gene
Expression
Omnibus
(GEO)
subgroups,
had
increased
overall
(OS)
time
=
0.014).
Combined
clinical
characteristics,
found
independent
factor
predicting
OS
patients.
ontology
(GO)
Kyoto
Encylopedia
Genes
Genomes
(KEGG)
analyses
indicated
immune-related
enriched
immune
status
decreased
conclusion,
play
important
roles
immunity
can
used
predict
OCs.
Cancer Science,
Journal Year:
2019,
Volume and Issue:
110(7), P. 2080 - 2089
Published: May 18, 2019
Regulatory
T
(Treg)
cells
suppress
abnormal/excessive
immune
responses
to
self-
and
nonself-antigens
maintain
homeostasis.
In
tumor
immunity,
Treg
are
involved
in
development
progression
by
inhibiting
antitumor
immunity.
There
several
cell
suppressive
mechanisms:
inhibition
of
costimulatory
signals
CD80
CD86
expressed
dendritic
through
cytotoxic
T-lymphocyte
antigen-4,
interleukin
(IL)-2
consumption
high-affinity
IL-2
receptors
with
high
CD25
(IL-2
receptor
α-chain)
expression,
secretion
inhibitory
cytokines,
metabolic
modulation
tryptophan
adenosine,
direct
killing
effector
cells.
Infiltration
into
the
microenvironment
(TME)
occurs
multiple
murine
human
tumors.
chemoattracted
TME
chemokine
gradients
such
as
CCR4-CCL17/22,
CCR8-CCL1,
CCR10-CCL28,
CXCR3-CCL9/10/11.
then
activated
inhibit
responses.
A
infiltration
is
associated
poor
survival
various
types
cancer.
Therefore,
strategies
deplete
control
functions
increase
urgently
required
cancer
immunotherapy
field.
Various
molecules
that
highly
cells,
checkpoint
molecules,
receptors,
metabolites,
have
been
targeted
Abs
or
small
but
additional
needed
fine-tune
optimize
for
augmenting
effects
restricted
while
avoiding
systemic
autoimmunity.
Here,
we
provide
a
brief
synopsis
these
how
they
can
be
controlled
achieve
therapeutic
outcomes.
Annual Review of Immunology,
Journal Year:
2020,
Volume and Issue:
38(1), P. 541 - 566
Published: Feb. 4, 2020
Naturally
occurring
CD4+
regulatory
T
cells
(Tregs),
which
specifically
express
the
transcription
factor
FoxP3
in
nucleus
and
CD25
CTLA-4
on
cell
surface,
are
a
functionally
distinct
subpopulation
actively
engaged
maintenance
of
immunological
self-tolerance
homeostasis.
Recent
studies
have
facilitated
our
understanding
cellular
molecular
basis
their
generation,
function,
phenotypic
functional
stability,
adaptability.
It
is
under
investigation
humans
how
or
numerical
Treg
anomalies,
whether
genetically
determined
environmentally
induced,
contribute
to
diseases
such
as
autoimmune
diseases.
Also
being
addressed
Tregs
can
be
targeted
control
physiological
pathological
immune
responses,
for
example,
by
depleting
them
enhance
tumor
immunity
expanding
treat
This
review
discusses
current
immunobiology
normal
disease
states,
with
perspective
realization
Treg-targeting
therapies
clinic.
Proceedings of the National Academy of Sciences,
Journal Year:
2019,
Volume and Issue:
116(20), P. 9999 - 10008
Published: April 26, 2019
Significance
PD-1
blockade
is
a
cancer
immunotherapy
effective
in
various
types
of
cancer.
However,
we
observed
rapid
progression,
called
hyperprogressive
disease
(HPD),
∼10%
advanced
gastric
patients
treated
with
anti–PD-1
monoclonal
antibody.
Tumors
HPD
possessed
highly
proliferating
FoxP3
+
Treg
cells
after
treatment,
contrasting
their
reduction
non-HPD
tumors.
In
vitro
augmented
proliferation
and
suppressive
activity
human
cells.
Likewise,
murine
that
were
deficient
signaling
more
proliferative
immunosuppressive.
Thus,
may
occur
when
activates
expands
tumor-infiltrating
to
overwhelm
tumor-reactive
effector
T
Depletion
the
former
therefore
help
treat
prevent
HPD.
Cancer Gene Therapy,
Journal Year:
2020,
Volume and Issue:
28(1-2), P. 5 - 17
Published: May 26, 2020
Cancer
immunotherapy
has
revolutionised
cancer
treatment,
with
immune
checkpoint
blockade
(ICB)
therapy
and
adoptive
cell
(ACT)
increasingly
becoming
standard
of
care
across
a
growing
number
indications.
While
the
majority
immunotherapies
focus
on
harnessing
anti-tumour
CD8+
cytotoxic
T
response,
potential
role
CD4+
'helper'
cells
largely
remained
in
background.
In
this
review,
we
give
an
overview
multifaceted
emphasis
recent
evidence
that
play
bigger
than
previously
thought.
We
illustrate
their
direct
potency
directing
sustained
response
against
tumours.
further
highlight
emerging
observation
responses
tumours
tend
to
be
self-derived
epitopes.
These
trends
raise
vital
questions
considerations
will
profoundly
affect
rational
design
leverage
full
system
cancer.
