Computer Modeling in Engineering & Sciences,
Journal Year:
2021,
Volume and Issue:
128(2), P. 489 - 522
Published: Jan. 1, 2021
In
recent
years,
the
development
of
artificial
intelligence
(AI)
and
gradual
beginning
AI’s
research
in
medical
field
have
allowed
people
to
see
excellent
prospects
integration
AI
healthcare.
Among
them,
hot
deep
learning
has
shown
greater
potential
applications
such
as
disease
prediction
drug
response
prediction.
From
initial
logistic
regression
model
machine
model,
then
today,
accuracy
been
continuously
improved,
performance
all
aspects
also
significantly
improved.
This
article
introduces
some
basic
frameworks
common
diseases,
summarizes
methods
corresponding
different
diseases.
Point
out
a
series
problems
current
prediction,
make
prospect
for
future
development.
It
aims
clarify
effectiveness
demonstrates
high
correlation
between
The
unique
feature
extraction
can
still
play
an
important
role
research.
Signal Transduction and Targeted Therapy,
Journal Year:
2020,
Volume and Issue:
5(1)
Published: March 20, 2020
Abstract
Colorectal
cancer
(CRC)
is
among
the
most
lethal
and
prevalent
malignancies
in
world
was
responsible
for
nearly
881,000
cancer-related
deaths
2018.
Surgery
chemotherapy
have
long
been
first
choices
patients.
However,
prognosis
of
CRC
has
never
satisfying,
especially
patients
with
metastatic
lesions.
Targeted
therapy
a
new
optional
approach
that
successfully
prolonged
overall
survival
Following
successes
anti-EGFR
(epidermal
growth
factor
receptor)
agent
cetuximab
anti-angiogenesis
bevacizumab,
agents
blocking
different
critical
pathways
as
well
immune
checkpoints
are
emerging
at
an
unprecedented
rate.
Guidelines
worldwide
currently
updating
recommended
targeted
drugs
on
basis
increasing
number
high-quality
clinical
trials.
This
review
provides
overview
existing
CRC-targeted
their
underlying
mechanisms,
discussion
limitations
future
trends.
Cell Death and Disease,
Journal Year:
2018,
Volume and Issue:
9(4)
Published: March 16, 2018
Abstract
Mounting
evidences
indicate
that
circular
RNAs
(circRNAs)
have
a
vital
role
in
human
diseases,
especially
cancers.
More
recently,
circHIPK3,
particularly
abundant
circRNA,
was
proposed
to
be
involved
tumorigenesis.
However,
its
colorectal
cancer
(CRC)
has
not
been
explored.
In
this
study,
we
found
circHIPK3
significantly
upregulated
CRC
tissues
and
cell
lines,
at
least
part,
due
c-Myb
overexpression
positively
correlated
with
metastasis
advanced
clinical
stage.
Moreover,
Cox
multivariate
survival
analysis
showed
high-level
expression
of
an
independent
prognostic
factor
poor
overall
(OS)
(hazard
ratio
[HR]
=
2.75,
95%
confidence
interval
[CI]
1.74–6.51,
p
0.009).
Functionally,
knockdown
markedly
inhibited
cells
proliferation,
migration,
invasion,
induced
apoptosis
vitro
suppressed
growth
vivo.
Mechanistically,
by
using
biotinylated-circHIPK3
probe
perform
RNA
pull-down
assay
cells,
identified
miR-7
the
only
one
microRNA
abundantly
pulled
down
both
HCT116
HT29
these
interactions
were
also
confirmed
biotinylated
dual-luciferase
reporter
assays.
Overexpression
mimicked
effect
on
apoptosis.
Furthermore,
ectopic
effectively
reversed
miR-7-induced
attenuation
malignant
phenotypes
increasing
levels
targeting
proto-oncogenes
(FAK,
IGF1R,
EGFR,
YY1).
Remarkably,
combination
silencing
gave
better
tumor
suppression
vivo
than
did
or
alone.
Taken
together,
our
data
may
considerable
potential
as
biomarker
CRC,
support
notion
therapeutic
c-Myb/circHIPK3/miR-7
axis
promising
treatment
approach
for
patients.
Cancer Cell,
Journal Year:
2018,
Volume and Issue:
33(4), P. 721 - 735.e8
Published: April 1, 2018
We
analyzed
921
adenocarcinomas
of
the
esophagus,
stomach,
colon,
and
rectum
to
examine
shared
distinguishing
molecular
characteristics
gastrointestinal
tract
(GIACs).
Hypermutated
tumors
were
distinct
regardless
cancer
type
comprised
those
enriched
for
insertions/deletions,
representing
microsatellite
instability
cases
with
epigenetic
silencing
MLH1
in
context
CpG
island
methylator
phenotype,
plus
elevated
single-nucleotide
variants
associated
mutations
POLE.
Tumors
chromosomal
diverse,
gastroesophageal
harboring
fragmented
genomes
genomic
doubling
mutational
signatures.
identified
a
group
colon
lacking
hypermutation
aneuploidy
termed
genome
stable
DNA
hypermethylation
KRAS,
SOX9,
PCBP1.
