Current understanding of iron homeostasis

American Journal of Clinical Nutrition, Journal Year: 2017, Volume and Issue: 106, P. 1559S - 1566S

Published: Oct. 25, 2017

Language: Английский

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Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

Nature Medicine, Journal Year: 2019, Volume and Issue: 25(8), P. 1234 - 1242

Published: July 22, 2019

Language: Английский

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GPCR-Mediated Signaling of Metabolites

Cell Metabolism, Journal Year: 2017, Volume and Issue: 25(4), P. 777 - 796

Published: April 1, 2017

Language: Английский

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The Potential of Gut Commensals in Reinforcing Intestinal Barrier Function and Alleviating Inflammation

Nutrients, Journal Year: 2018, Volume and Issue: 10(8), P. 988 - 988

Published: July 29, 2018

The intestinal microbiota, composed of pro- and anti-inflammatory microbes, has an essential role in maintaining gut homeostasis functionality. An overly hygienic lifestyle, consumption processed fiber-poor foods, or antibiotics are major factors modulating the microbiota possibly leading to longstanding dysbiosis. Dysbiotic is characterized have altered composition, reduced diversity stability, as well increased levels lipopolysaccharide-containing, proinflammatory bacteria. Specific commensal species novel probiotics, so-called next-generation could restore health by means attenuating inflammation strengthening epithelial barrier. In this review we summarize latest findings considering beneficial effects promising commensals across all phyla. These include already well-known bifidobacteria, which use extracellular structures secreted substances promote health. Faecalibacterium prausnitzii, Roseburia intestinalis, Eubacterium hallii metabolize dietary fibers short-chain fatty acid producers providing energy sources for enterocytes achieving gut. Akkermansia muciniphila exerts action metabolic diseases fortifies barrier function. health-promoting Bacteroides relatively recently discovered with excreted immunomodulatory molecules. promising, unconventional probiotics be a part biotherapeutic strategies future.

Language: Английский

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The gut microbiome and liver cancer: mechanisms and clinical translation

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2017, Volume and Issue: 14(9), P. 527 - 539

Published: July 5, 2017

Language: Английский

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The Short-Chain Fatty Acid Acetate in Body Weight Control and Insulin Sensitivity

Nutrients, Journal Year: 2019, Volume and Issue: 11(8), P. 1943 - 1943

Published: Aug. 18, 2019

The interplay of gut microbiota, host metabolism, and metabolic health has gained increased attention. Gut microbiota may play a regulatory role in gastrointestinal health, substrate peripheral tissues including adipose tissue, skeletal muscle, liver, pancreas via its metabolites short-chain fatty acids (SCFA). Animal human data demonstrated that, particular, acetate beneficially affects energy metabolism secretion the hormones like glucagon-like peptide-1 peptide YY, which, thereby, appetite, reduction whole-body lipolysis, systemic pro-inflammatory cytokine levels, an increase expenditure fat oxidation. Thus, potential therapies to microbial fermentation production have been under vigorous scientific scrutiny. In this review, relevance colonically systemically most abundant SCFA effects on previously mentioned will be discussed relation body weight control glucose homeostasis. We discuss detail differential oral administration (vinegar intake), colonic infusions, acetogenic fiber, probiotic administrations as approaches combat obesity comorbidities. Notably, are scarce, which highlights necessity for further research investigate acetate’s physiology, metabolic, cardiovascular health.

Language: Английский

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Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential

Nature Medicine, Journal Year: 2018, Volume and Issue: 24(9), P. 1407 - 1417

Published: July 26, 2018

Language: Английский

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Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis

Cell Host & Microbe, Journal Year: 2022, Volume and Issue: 30(3), P. 289 - 300

Published: March 1, 2022

Language: Английский

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Fight them or feed them: how the intestinal mucus layer manages the gut microbiota

Gastroenterology report, Journal Year: 2018, Volume and Issue: 7(1), P. 3 - 12

Published: Dec. 18, 2018

The intestinal tract is inhabited by a tremendous number of microorganisms, termed the gut microbiota. These microorganisms live in mutualistic relationship with their host and assist degradation complex carbohydrates. Although microbiota generally considered beneficial, vast microbial cells also form permanent threat to host. Thus, epithelium covered dense layer mucus prevent translocation into underlying tissues. Intestinal an organized glycoprotein network host-specific glycan structure. While has long been passive, host-designed barrier, recent studies showed that maturation function are strongly influenced In return, repertoire mucins can select for distinct mucosa-associated bacteria able bind or degrade specific mucin glycans as nutrient source. Because at crucial interface between microbes, its breakdown leads bacterial encroachment eventually cause inflammation infection. Accordingly, dysfunctional observed colitis mice humans. Moreover, increased consumption low-fiber Western-style diet our modern society recently demonstrated bacteria-mediated defects layer. Here, I will review current knowledge on interaction health disease. Understanding molecular details this host-microbe may contribute development novel treatment options diseases involving layer, such ulcerative colitis.

Language: Английский

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Gut Microbiota: An Integral Moderator in Health and Disease

Frontiers in Microbiology, Journal Year: 2018, Volume and Issue: 9

Published: Feb. 21, 2018

The gut microbiota, as the main member in microecology, is an essential mediator health and disease. microbiota interacts with various organs systems body, including brain, lung, liver, bone, cardiovascular system others. Microbiota-derived metabolites such short chain fatty acid (SCFA) butyrate are primary signals, which link physiology. Recently, has been identified origin of a number diseases by influencing related cell signaling pathways WNT/beta-catenin pathway colorectal cancer T receptor central nervous system. Moreover, several microRNAs participate networks through intervention microbiota. interaction between miRNAs plays crucial role vascular dysfunction hepatocellular carcinoma (HCC). In this review, we will report discuss recent findings about crosstalk physical how regulate each other while host via genes, proteins or metabolites.

Language: Английский

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