Microbial tryptophan catabolites in health and disease

Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)

Published: Aug. 13, 2018

Accumulating evidence implicates metabolites produced by gut microbes as crucial mediators of diet-induced host-microbial cross-talk. Here, we review emerging data suggesting that microbial tryptophan catabolites resulting from proteolysis are influencing host health. These suggested to activate the immune system through binding aryl hydrocarbon receptor (AHR), enhance intestinal epithelial barrier, stimulate gastrointestinal motility, well secretion hormones, exert anti-inflammatory, anti-oxidative or toxic effects in systemic circulation, and putatively modulate composition. Tryptophan thus affect various physiological processes may contribute homeostasis health disease.

Language: Английский

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Glucagon-like peptide 1 (GLP-1)

Molecular Metabolism, Journal Year: 2019, Volume and Issue: 30, P. 72 - 130

Published: Sept. 30, 2019

Background: The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential.Among the numerous metabolic effects of GLP-1 are glucose-dependent stimulation insulin secretion, decrease gastric emptying, inhibition food intake, increase natriuresis and diuresis, modulation rodent b-cell proliferation.GLP-1 also has cardio-and neuroprotective effects, decreases inflammation apoptosis, implications for learning memory, reward behavior, palatability.Biochemically modified enhanced potency sustained action, receptor agonists successfully in clinical use treatment type-2 diabetes, several GLP-1-based pharmacotherapies evaluation obesity.Scope review: In this review, we provide detailed overview on nature its pharmacology discuss therapeutic various diseases.Major conclusions: Since discovery, emerged as pleiotropic myriad functions that go well beyond classical identification an incretin hormone.The beneficial render interesting candidate development to treat obesity, neurodegenerative disorders

Language: Английский

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Human gut microbiome: hopes, threats and promises

Gut, Journal Year: 2018, Volume and Issue: 67(9), P. 1716 - 1725

Published: June 22, 2018

The microbiome has received increasing attention over the last 15 years. Although gut microbes have been explored for several decades, investigations of role microorganisms that reside in human attracted much beyond classical infectious diseases. For example, numerous studies reported changes microbiota during not only obesity, diabetes, and liver diseases but also cancer even neurodegenerative is viewed as a potential source novel therapeutics. Between 2013 2017, number publications focusing on was, remarkably, 12 900, which represents four-fifths total 40 years investigated this topic. This review discusses recent evidence impact metabolic disorders focus selected key mechanisms. aims to provide critical analysis current knowledge field, identify putative issues or problems discuss misinterpretations. abundance metagenomic data generated comparing diseased healthy subjects can lead erroneous claim bacterium causally linked with protection onset disease. In fact, environmental factors such dietary habits, drug treatments, intestinal motility stool frequency consistency are all influence composition should be considered. cases bacteria Prevotella copri Akkermansia muciniphila will discussed examples.

Language: Английский

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Gut microbial metabolites as multi-kingdom intermediates

Nature Reviews Microbiology, Journal Year: 2020, Volume and Issue: 19(2), P. 77 - 94

Published: Sept. 23, 2020

Language: Английский

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Identification of bioactive metabolites using activity metabolomics

Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 20(6), P. 353 - 367

Published: Feb. 27, 2019

Language: Английский

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Microbes, metabolites, and the gut–lung axis

Mucosal Immunology, Journal Year: 2019, Volume and Issue: 12(4), P. 843 - 850

Published: April 11, 2019

Language: Английский

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Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice

Nature Microbiology, Journal Year: 2021, Volume and Issue: 6(5), P. 563 - 573

Published: April 5, 2021

Language: Английский

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Small molecule metabolites: discovery of biomarkers and therapeutic targets

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: March 20, 2023

Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks diseases. Metabolite signatures that have close proximity subject's phenotypic informative dimension, are useful for predicting diagnosis prognosis diseases as well monitoring treatments. The lack early biomarkers could poor serious outcomes. Therefore, noninvasive methods with high specificity selectivity desperately needed. Small molecule metabolites-based metabolomics has become a specialized tool biomarker pathway analysis, revealing possible mechanisms human various deciphering therapeutic potentials. It help identify functional related variation delineate biochemical changes indicators pathological damage prior disease development. Recently, scientists established large number profiles reveal underlying networks target exploration in biomedicine. This review summarized analysis on potential value small-molecule candidate metabolites clinical events, may better diagnosis, prognosis, drug screening treatment. We also discuss challenges need be addressed fuel next wave breakthroughs.

Language: Английский

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Interplay between YAP/TAZ and Metabolism

Cell Metabolism, Journal Year: 2018, Volume and Issue: 28(2), P. 196 - 206

Published: Aug. 1, 2018

Language: Английский

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Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2018, Volume and Issue: 15(11), P. 671 - 682

Published: May 29, 2018

Language: Английский

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