Clinical Microbiology Reviews,
Journal Year:
2022,
Volume and Issue:
35(1)
Published: Jan. 5, 2022
The
human
body
is
full
of
an
extensive
number
commensal
microbes,
consisting
bacteria,
viruses,
and
fungi,
collectively
termed
the
microbiome.
initial
acquisition
microbiota
occurs
from
both
external
maternal
environments,
vast
majority
them
colonize
gastrointestinal
tract
(GIT).
These
microbial
communities
play
a
central
role
in
maturation
development
immune
system,
nervous
GIT
system
are
also
responsible
for
essential
metabolic
pathways.
Various
factors,
including
host
genetic
predisposition,
environmental
lifestyle,
diet,
antibiotic
or
nonantibiotic
drug
use,
etc.,
affect
composition
gut
microbiota.
Recent
publications
have
highlighted
that
imbalance
microflora,
known
as
dysbiosis,
associated
with
onset
progression
neurological
disorders.
Moreover,
characterization
microbiome-host
cross
talk
pathways
provides
insight
into
novel
therapeutic
strategies.
Novel
preclinical
clinical
research
on
interventions
related
to
microbiome
treating
conditions,
autism
spectrum
disorders,
Parkinson's
disease,
schizophrenia,
multiple
sclerosis,
Alzheimer's
epilepsy,
stroke,
hold
significant
promise.
This
review
aims
present
comprehensive
overview
potential
involvement
pathogenesis
particular
emphasis
microbe-based
therapies
and/or
diagnostic
biomarkers.
discusses
health
benefits
administration
probiotics,
prebiotics,
postbiotics,
synbiotics
fecal
transplantation
International Journal of Molecular Sciences,
Journal Year:
2019,
Volume and Issue:
20(5), P. 1214 - 1214
Published: March 11, 2019
Secondary
bile
acids
(BAs)
and
short
chain
fatty
(SCFAs),
two
major
types
of
bacterial
metabolites
in
the
colon,
cause
opposing
effects
on
colonic
inflammation
at
chronically
high
physiological
levels.
Primary
BAs
play
critical
roles
cholesterol
metabolism,
lipid
digestion,
host⁻microbe
interaction.
Although
are
reabsorbed
via
enterohepatic
circulation,
primary
serve
as
substrates
for
biotransformation
to
secondary
colon.
High-fat
diets
increase
BAs,
such
deoxycholic
acid
(DCA)
lithocholic
(LCA),
which
risk
factors
cancer.
In
contrast,
increased
dietary
fiber
intake
is
associated
with
anti-inflammatory
anticancer
effects.
These
may
be
due
production
SCFAs
acetate,
propionate,
butyrate
during
fermentation
Elucidation
molecular
events
by
regulate
cell
proliferation
will
lead
a
better
understanding
potential
context
high-fat
diet-related
colon
This
article
reviews
current
knowledge
concerning
epithelial
cells,
inflammation,
cancer,
microbiome.
Protein & Cell,
Journal Year:
2020,
Volume and Issue:
12(5), P. 360 - 373
Published: Dec. 21, 2020
Abstract
It
is
well
known
that
an
unhealthy
lifestyle
a
major
risk
factor
for
metabolic
diseases,
while
in
recent
years,
accumulating
evidence
has
demonstrated
the
gut
microbiome
and
its
metabolites
also
play
crucial
role
onset
development
of
many
including
obesity,
type
2
diabetes,
nonalcoholic
fatty
liver
disease,
cardiovascular
disease
so
on.
Numerous
microorganisms
dwell
gastrointestinal
tract,
which
key
interface
energy
acquisition
can
metabolize
dietary
nutrients
into
bioactive
substances,
thus
acting
as
link
between
host.
The
shaped
by
host
genetics,
immune
responses
factors.
potential
determines
significance
health
diseases.
Therefore,
targeting
relevant
pathways
would
be
effective
therapeutic
treatments
diseases
near
future.
This
review
will
summarize
information
about
organism
metabolism
relationship
microbiome-derived
pathogenesis
Furthermore,
advances
improving
regulating
discussed.
Clinical Microbiology Reviews,
Journal Year:
2022,
Volume and Issue:
35(1)
Published: Jan. 5, 2022
The
human
body
is
full
of
an
extensive
number
commensal
microbes,
consisting
bacteria,
viruses,
and
fungi,
collectively
termed
the
microbiome.
initial
acquisition
microbiota
occurs
from
both
external
maternal
environments,
vast
majority
them
colonize
gastrointestinal
tract
(GIT).
These
microbial
communities
play
a
central
role
in
maturation
development
immune
system,
nervous
GIT
system
are
also
responsible
for
essential
metabolic
pathways.
Various
factors,
including
host
genetic
predisposition,
environmental
lifestyle,
diet,
antibiotic
or
nonantibiotic
drug
use,
etc.,
affect
composition
gut
microbiota.
Recent
publications
have
highlighted
that
imbalance
microflora,
known
as
dysbiosis,
associated
with
onset
progression
neurological
disorders.
Moreover,
characterization
microbiome-host
cross
talk
pathways
provides
insight
into
novel
therapeutic
strategies.
Novel
preclinical
clinical
research
on
interventions
related
to
microbiome
treating
conditions,
autism
spectrum
disorders,
Parkinson's
disease,
schizophrenia,
multiple
sclerosis,
Alzheimer's
epilepsy,
stroke,
hold
significant
promise.
This
review
aims
present
comprehensive
overview
potential
involvement
pathogenesis
particular
emphasis
microbe-based
therapies
and/or
diagnostic
biomarkers.
discusses
health
benefits
administration
probiotics,
prebiotics,
postbiotics,
synbiotics
fecal
transplantation
