Genome Regulation by Polycomb and Trithorax: 70 Years and Counting

Cell, Journal Year: 2017, Volume and Issue: 171(1), P. 34 - 57

Published: Sept. 1, 2017

Language: Английский

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How many human proteoforms are there?

Nature Chemical Biology, Journal Year: 2018, Volume and Issue: 14(3), P. 206 - 214

Published: Feb. 14, 2018

Language: Английский

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CGCG clinical practice guidelines for the management of adult diffuse gliomas

Cancer Letters, Journal Year: 2016, Volume and Issue: 375(2), P. 263 - 273

Published: March 7, 2016

The Chinese Glioma Cooperative Group (CGCG) Guideline Panel for adult diffuse gliomas provided recommendations diagnostic and therapeutic procedures. covered all fields of expertise in neuro-oncology, i.e. neurosurgeons, neurologists, neuropathologists, neuroradiologists, radiation medical oncologists clinical trial experts. task made clearer more transparent choices about outcomes considered most relevant through searching the references evaluating their value. scientific evidence papers collected from literature was evaluated graded based on Oxford Centre Evidence-based Medicine Levels Evidence were given accordingly. will provide a framework assurance strategy measures to reduce complications unnecessary treatment cost. guideline should serve as an application professionals involved management patients with glioma also source knowledge insurance companies other institutions cost regulation cancer care China.

Language: Английский

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The roles of DNA, RNA and histone methylation in ageing and cancer

Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 20(10), P. 573 - 589

Published: July 3, 2019

Language: Английский

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Targeting glioma stem cells through combined BMI1 and EZH2 inhibition

Nature Medicine, Journal Year: 2017, Volume and Issue: 23(11), P. 1352 - 1361

Published: Oct. 9, 2017

Language: Английский

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H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: March 19, 2019

Abstract Lys-27-Met mutations in histone 3 genes (H3K27M) characterize a subgroup of deadly gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary H3K27M tumor lines isogenic CRISPR-edited controls to assess effects vitro vivo. We find that whereas H3K27me3 H3K27me2 are normally deposited by PRC2 across broad regions, their deposition is severely reduced H3.3K27M cells. unable spread from large unmethylated CpG islands, while can be outside these high-affinity sites but levels corresponding wild-type Our findings indicate recruitment propagation on chromatin seemingly unaffected K27M, which mostly impairs the repressive marks it catalyzes, especially H3K27me3. Genome-wide loss me2 has limited transcriptomic consequences, preferentially affecting lowly-expressed regulating neurogenesis. Removal restores H3K27me2/me3 spread, cell proliferation, completely abolishes capacity form tumors mice.

Language: Английский

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The roles of Polycomb repressive complexes in mammalian development and cancer

Nature Reviews Molecular Cell Biology, Journal Year: 2021, Volume and Issue: 22(5), P. 326 - 345

Published: March 15, 2021

Language: Английский

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Clinical practice guidelines for the management of adult diffuse gliomas

Cancer Letters, Journal Year: 2020, Volume and Issue: 499, P. 60 - 72

Published: Nov. 6, 2020

Language: Английский

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Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation

Nature Genetics, Journal Year: 2020, Volume and Issue: 52(12), P. 1271 - 1281

Published: Nov. 30, 2020

Language: Английский

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Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression

Cancer Cell, Journal Year: 2018, Volume and Issue: 35(1), P. 140 - 155.e7

Published: Dec. 27, 2018

Language: Английский

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