Nature Genetics, Journal Year: 2022, Volume and Issue: 54(12), P. 1865 - 1880
Published: Dec. 1, 2022
Language: Английский
Nature Genetics, Journal Year: 2022, Volume and Issue: 54(12), P. 1865 - 1880
Published: Dec. 1, 2022
Language: Английский
Cell, Journal Year: 2017, Volume and Issue: 171(1), P. 34 - 57
Published: Sept. 1, 2017
Language: Английский
Citations
989Nature Chemical Biology, Journal Year: 2018, Volume and Issue: 14(3), P. 206 - 214
Published: Feb. 14, 2018
Language: Английский
Citations
799Cancer Letters, Journal Year: 2016, Volume and Issue: 375(2), P. 263 - 273
Published: March 7, 2016
The Chinese Glioma Cooperative Group (CGCG) Guideline Panel for adult diffuse gliomas provided recommendations diagnostic and therapeutic procedures. covered all fields of expertise in neuro-oncology, i.e. neurosurgeons, neurologists, neuropathologists, neuroradiologists, radiation medical oncologists clinical trial experts. task made clearer more transparent choices about outcomes considered most relevant through searching the references evaluating their value. scientific evidence papers collected from literature was evaluated graded based on Oxford Centre Evidence-based Medicine Levels Evidence were given accordingly. will provide a framework assurance strategy measures to reduce complications unnecessary treatment cost. guideline should serve as an application professionals involved management patients with glioma also source knowledge insurance companies other institutions cost regulation cancer care China.
Language: Английский
Citations
554Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 20(10), P. 573 - 589
Published: July 3, 2019
Language: Английский
Citations
452Nature Medicine, Journal Year: 2017, Volume and Issue: 23(11), P. 1352 - 1361
Published: Oct. 9, 2017
Language: Английский
Citations
329Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)
Published: March 19, 2019
Abstract Lys-27-Met mutations in histone 3 genes (H3K27M) characterize a subgroup of deadly gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary H3K27M tumor lines isogenic CRISPR-edited controls to assess effects vitro vivo. We find that whereas H3K27me3 H3K27me2 are normally deposited by PRC2 across broad regions, their deposition is severely reduced H3.3K27M cells. unable spread from large unmethylated CpG islands, while can be outside these high-affinity sites but levels corresponding wild-type Our findings indicate recruitment propagation on chromatin seemingly unaffected K27M, which mostly impairs the repressive marks it catalyzes, especially H3K27me3. Genome-wide loss me2 has limited transcriptomic consequences, preferentially affecting lowly-expressed regulating neurogenesis. Removal restores H3K27me2/me3 spread, cell proliferation, completely abolishes capacity form tumors mice.
Language: Английский
Citations
302Nature Reviews Molecular Cell Biology, Journal Year: 2021, Volume and Issue: 22(5), P. 326 - 345
Published: March 15, 2021
Language: Английский
Citations
298Cancer Letters, Journal Year: 2020, Volume and Issue: 499, P. 60 - 72
Published: Nov. 6, 2020
Language: Английский
Citations
297Nature Genetics, Journal Year: 2020, Volume and Issue: 52(12), P. 1271 - 1281
Published: Nov. 30, 2020
Language: Английский
Citations
294Cancer Cell, Journal Year: 2018, Volume and Issue: 35(1), P. 140 - 155.e7
Published: Dec. 27, 2018
Language: Английский
Citations
244