Microbiome–microglia connections via the gut–brain axis DOI Creative Commons
Reem Abdel-Haq, Johannes C. M. Schlachetzki, Christopher K. Glass

et al.

The Journal of Experimental Medicine, Journal Year: 2018, Volume and Issue: 216(1), P. 41 - 59

Published: Nov. 1, 2018

Microglia, the resident immune cells in brain, are essential for modulating neurogenesis, influencing synaptic remodeling, and regulating neuroinflammation by surveying brain microenvironment. Microglial dysfunction has been implicated onset progression of several neurodevelopmental neurodegenerative diseases; however, multitude factors signals microglial activity have not fully elucidated. Microglia only respond to local within but also receive input from periphery, including gastrointestinal (GI) tract. Recent preclinical findings suggest that gut microbiome plays a pivotal role maturation function, altered microbial community composition reported neurological disorders with known involvement humans. Collectively, these bidirectional crosstalk between may influence disease pathogenesis. Herein, we discuss recent studies showing development function homeostatic conditions highlight possible future research develop novel treatments brain.

Language: Английский

Astrocytes in chronic pain and itch DOI
Ru‐Rong Ji, Christopher R. Donnelly, Maiken Nedergaard

et al.

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(11), P. 667 - 685

Published: Sept. 19, 2019

Language: Английский

Citations

405
Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology DOI

Sofie Voet,

Marco Prinz, Geert Loo

et al.

Trends in Molecular Medicine, Journal Year: 2018, Volume and Issue: 25(2), P. 112 - 123

Published: Dec. 18, 2018

Language: Английский

Citations

403
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies DOI Creative Commons
Borislav Dejanovic, Melanie A. Huntley, Ann De Mazière

et al.

Neuron, Journal Year: 2018, Volume and Issue: 100(6), P. 1322 - 1336.e7

Published: Nov. 1, 2018

Language: Английский

Citations

399
CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development DOI Creative Commons

Emily K. Lehrman,

Daniel K. Wilton, Elizabeth Y. Litvina

et al.

Neuron, Journal Year: 2018, Volume and Issue: 100(1), P. 120 - 134.e6

Published: Oct. 1, 2018

Language: Английский

Citations

384
Microbiome–microglia connections via the gut–brain axis DOI Creative Commons
Reem Abdel-Haq, Johannes C. M. Schlachetzki, Christopher K. Glass

et al.

The Journal of Experimental Medicine, Journal Year: 2018, Volume and Issue: 216(1), P. 41 - 59

Published: Nov. 1, 2018

Microglia, the resident immune cells in brain, are essential for modulating neurogenesis, influencing synaptic remodeling, and regulating neuroinflammation by surveying brain microenvironment. Microglial dysfunction has been implicated onset progression of several neurodevelopmental neurodegenerative diseases; however, multitude factors signals microglial activity have not fully elucidated. Microglia only respond to local within but also receive input from periphery, including gastrointestinal (GI) tract. Recent preclinical findings suggest that gut microbiome plays a pivotal role maturation function, altered microbial community composition reported neurological disorders with known involvement humans. Collectively, these bidirectional crosstalk between may influence disease pathogenesis. Herein, we discuss recent studies showing development function homeostatic conditions highlight possible future research develop novel treatments brain.

Language: Английский

Citations

371