Frontiers in Cellular and Infection Microbiology,
Journal Year:
2021,
Volume and Issue:
11
Published: June 14, 2021
Antibiotics
are
essential
drugs
used
to
treat
pathogenic
bacteria,
but
their
prolonged
use
contributes
the
development
and
spread
of
drug-resistant
microorganisms.
Antibiotic
resistance
is
a
serious
challenge
has
led
need
for
new
alternative
molecules
less
prone
bacterial
resistance.
Antimicrobial
peptides
(AMPs)
have
aroused
great
interest
as
potential
next-generation
antibiotics,
since
they
bioactive
small
proteins,
naturally
produced
by
all
living
organisms,
representing
first
line
defense
against
fungi,
viruses
bacteria.
AMPs
commonly
classified
according
sources,
which
represented
microorganisms,
plants
animals,
well
secondary
structure,
biosynthesis
mechanism
action.
They
find
application
in
different
fields
such
agriculture,
food
industry
medicine,
on
we
focused
our
attention
this
review.
Particularly,
examined
AMP
applicability
wound
healing,
skin
infections
metabolic
syndrome,
considering
ability
act
Angiotensin-Converting
Enzyme
I
pancreatic
lipase
inhibitory
antioxidant
peptides.
Moreover,
argued
about
pharmacokinetic
pharmacodynamic
approaches
develop
drug
strategies
formulation
be
taken
into
account
developing
clinically
suitable
applications.
Frontiers in Pharmacology,
Journal Year:
2018,
Volume and Issue:
9
Published: Jan. 22, 2018
Drug
development
is
a
lengthy
and
costly
process
that
proceeds
through
several
stages
from
target
identification
to
lead
discovery
optimization,
preclinical
validation
clinical
trials
culminating
in
approval
for
use.
An
important
step
this
high-throughput
screening
(HTS)
of
small
compound
libraries
identification.
Currently,
the
majority
cell-based
HTS
being
carried
out
on
cultured
cells
propagated
two-dimensions
(2D)
plastic
surfaces
optimized
tissue
culture.
At
same
time,
compelling
evidence
suggests
these
non-physiological
conditions
are
not
representative
residing
complex
microenvironment
tissue.
This
discrepancy
thought
be
significant
contributor
high
failure
rate
drug
discovery,
where
only
low
percentage
drugs
investigated
ever
make
it
gamut
testing
market.
Thus,
three-dimensional
(3D)
cell
culture
technologies
more
closely
resemble
vivo
environments
now
pursued
with
intensity
as
they
expected
accommodate
better
precision
discovery.
Here
we
will
review
common
approaches
3D
culture,
discuss
significance
cultures
resistance
repositioning
address
some
challenges
applying
Advanced Science,
Journal Year:
2018,
Volume and Issue:
5(5)
Published: Feb. 22, 2018
Antibacterial
materials
are
recognized
as
important
biomaterials
due
to
their
effective
inhibition
of
bacterial
infections.
Hydrogels
3D
polymer
networks
crosslinked
by
either
physical
interactions
or
covalent
bonds.
Currently,
hydrogels
with
an
antibacterial
function
a
main
focus
in
biomedical
research.
Many
advanced
developed,
each
possessing
unique
qualities,
namely
high
water
swellability,
oxygen
permeability,
improved
biocompatibility,
ease
loading
and
releasing
drugs,
structural
diversity.
Here,
overview
the
structures,
performances,
mechanisms
action,
release
behaviors,
applications
various
hydrogel
formulations
is
provided.
Furthermore,
prospects
research
clinical
predicted.
Advanced Functional Materials,
Journal Year:
2019,
Volume and Issue:
30(2)
Published: April 10, 2019
Abstract
Adhering
hydrogels
to
various
materials
is
fundamental
a
large
array
of
established
and
emerging
applications.
The
last
few
years
have
seen
transformative
advances
in
achieving
strong
hydrogel
adhesion,
which
supramolecular
phenomenon.
Two
adherends
connect
through
covalent
bonds,
noncovalent
complexes,
polymer
chains,
networks,
or
nanoparticles.
Separating
the
dissipates
energy
cascading
events
across
length
scales,
including
bond
cleavage,
chain
retraction,
bulk
hysteresis.
A
unifying
principle
has
emerged:
adhesion
requires
synergy
chemistry
topology
connection,
mechanics
dissipation.
This
characterizes
(another
hydrogel,
tissue,
elastomer,
plastic,
metal,
glass,
ceramic)
operations
(cast,
coat,
print,
attach,
pierce,
glue).
Strong
can
be
made
permanent,
reversible,
degradable,
on‐demand
detachable.
development
its
applications
adheres
disciplines,
discovers
interlinks,
forges
cohesion.
Discussed
throughout
review
are
immediate
opportunities
for
studies
practical
Materials Science and Engineering R Reports,
Journal Year:
2020,
Volume and Issue:
140, P. 100543 - 100543
Published: Feb. 18, 2020
3D
printing
alias
additive
manufacturing
can
transform
virtual
models
created
by
computer-aided
design
(CAD)
into
physical
objects
in
a
layer-by-layer
manner
dispensing
with
conventional
molding
or
machining.
Since
the
incipiency,
significant
advancements
have
been
achieved
understanding
process
of
and
relationship
component,
structure,
property
application
objects.
Because
hydrogels
are
one
most
feasible
classes
ink
materials
for
this
field
has
rapidly
advancing,
Review
focuses
on
hydrogel
designs
development
advanced
hydrogel-based
biomaterial
inks
bioinks
printing.
It
covers
techniques
including
laser
(stereolithography,
two-photon
polymerization),
extrusion
(3D
plotting,
direct
writing),
inkjet
printing,
bioprinting,
4D
bioprinting.
provides
comprehensive
overview
discussion
tailorability
material,
mechanical,
physical,
chemical
biological
properties
to
enable
The
range
hydrogel-forming
polymers
covered
encompasses
biopolymers,
synthetic
polymers,
polymer
blends,
nanocomposites,
functional
cell-laden
systems.
representative
biomedical
applications
selected
demonstrate
how
is
being
exploited
tissue
engineering,
regenerative
medicine,
cancer
research,
vitro
disease
modeling,
high-throughput
drug
screening,
surgical
preparation,
soft
robotics
flexible
wearable
electronics.
Incomparable
thermoplastics,
thermosets,
ceramics
metals,
playing
pivotal
role
creation
(bio)systems
customizable
way.
An
outlook
future
directions
presented.
Chemical Reviews,
Journal Year:
2017,
Volume and Issue:
117(20), P. 12764 - 12850
Published: Oct. 9, 2017
The
cell
microenvironment
has
emerged
as
a
key
determinant
of
behavior
and
function
in
development,
physiology,
pathophysiology.
extracellular
matrix
(ECM)
within
the
serves
not
only
structural
foundation
for
cells
but
also
source
three-dimensional
(3D)
biochemical
biophysical
cues
that
trigger
regulate
behaviors.
Increasing
evidence
suggests
3D
character
is
required
development
many
critical
responses
observed
vivo,
fueling
surge
functional
biomimetic
materials
engineering
microenvironment.
Progress
design
such
improved
control
behaviors
advanced
fields
tissue
regeneration,
vitro
models,
large-scale
differentiation,
immunotherapy,
gene
therapy.
However,
field
still
its
infancy,
discoveries
about
nature
cell–microenvironment
interactions
continue
to
overturn
much
early
progress
field.
Key
challenges
be
dissecting
roles
chemistry,
structure,
mechanics,
electrophysiology
microenvironment,
understanding
harnessing
periodicity
drift
these
factors.
This
review
encapsulates
where
recent
advances
appear
leave
ever-shifting
state
art,
it
highlights
areas
which
substantial
potential
uncertainty
remain.
