Molecular Psychiatry, Journal Year: 2016, Volume and Issue: 22(5), P. 689 - 702
Published: March 29, 2016
Language: Английский
Molecular Psychiatry, Journal Year: 2016, Volume and Issue: 22(5), P. 689 - 702
Published: March 29, 2016
Language: Английский
Cold Spring Harbor Perspectives in Biology, Journal Year: 2012, Volume and Issue: 4(3), P. a009886 - a009886
Published: Jan. 18, 2012
Huda Y. Zoghbi1 and Mark F. Bear2 Howard Hughes Medical Institute, The Jan Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, 77030; Department of Neuroscience Molecular Human Genetics, Baylor College Medicine, 77030 Picower for Learning Memory, Brain Cognitive Sciences, Massachusetts Technology, Cambridge, 02139 Correspondence: hzoghbi{at}bcm.edu; mbear{at}mit.edu
Language: Английский
Citations
750Neuron, Journal Year: 2013, Volume and Issue: 79(5), P. 887 - 902
Published: Sept. 1, 2013
Language: Английский
Citations
526Nature Neuroscience, Journal Year: 2013, Volume and Issue: 16(11), P. 1530 - 1536
Published: April 14, 2013
Language: Английский
Citations
470Neuron, Journal Year: 2015, Volume and Issue: 87(4), P. 699 - 715
Published: Aug. 1, 2015
Language: Английский
Citations
384Nature, Journal Year: 2012, Volume and Issue: 493(7432), P. 411 - 415
Published: Dec. 21, 2012
Language: Английский
Citations
345Nature Communications, Journal Year: 2016, Volume and Issue: 7(1)
Published: May 10, 2016
Abstract Human neuroimaging studies suggest that aberrant neural connectivity underlies behavioural deficits in autism spectrum disorders (ASDs), but the molecular and circuit mechanisms underlying ASDs remain elusive. Here, we describe a complete knockout mouse model of autism-associated Shank3 gene, with deletion exons 4–22 (Δe4–22). Both mGluR5-Homer scaffolds mGluR5-mediated signalling are selectively altered striatal neurons. These changes associated perturbed function at synapses, abnormal brain morphology, structural ASD-like behaviour. In vivo recording reveals cortico-striatal-thalamic is tonically hyperactive mutants, becomes hypoactive during social Manipulation mGluR5 activity attenuates excessive grooming instrumental learning differentially, rescues impaired synaptic plasticity Δe4–22 −/− mice. findings show deficiency can impair scaffolding, resulting cortico-striatal abnormalities underlie behaviours. data causal links between genetic, molecular, pathophysiology ASDs.
Language: Английский
Citations
296Cell, Journal Year: 2014, Volume and Issue: 156(1-2), P. 195 - 207
Published: Jan. 1, 2014
Language: Английский
Citations
282Neuron, Journal Year: 2019, Volume and Issue: 101(6), P. 1070 - 1088
Published: March 1, 2019
Language: Английский
Citations
282Annual Review of Physiology, Journal Year: 2014, Volume and Issue: 77(1), P. 251 - 270
Published: Nov. 11, 2014
It is well established that the active properties of nerve and muscle cells are stabilized by homeostatic signaling systems. In organisms ranging from Drosophila to humans, neurons restore baseline function in continued presence destabilizing perturbations rebalancing ion channel expression, modifying neurotransmitter receptor surface expression trafficking, modulating release. This review focuses on modulation presynaptic release, termed homeostasis. First, we highlight criteria can be used define a process as being under control. Next, remarkable conservation homeostasis at Drosophila, mouse, human neuromuscular junctions emerging parallels synaptic connections mammalian central nervous system. We then recent progress identifying cellular molecular mechanisms. conclude reviewing between mechanisms genetic links neurological disease.
Language: Английский
Citations
263Neuron, Journal Year: 2013, Volume and Issue: 80(3), P. 718 - 728
Published: Oct. 1, 2013
Language: Английский
Citations
262