FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

Cell, Journal Year: 2015, Volume and Issue: 162(2), P. 375 - 390

Published: July 1, 2015

Language: Английский

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Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

Neuron, Journal Year: 2014, Volume and Issue: 83(5), P. 1131 - 1143

Published: Aug. 21, 2014

Language: Английский

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Activity-dependent neuronal signalling and autism spectrum disorder

Nature, Journal Year: 2013, Volume and Issue: 493(7432), P. 327 - 337

Published: Jan. 15, 2013

Language: Английский

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The Postsynaptic Organization of Synapses

Cold Spring Harbor Perspectives in Biology, Journal Year: 2011, Volume and Issue: 3(12), P. a005678 - a005678

Published: Nov. 1, 2011

Morgan Sheng1 and Eunjoon Kim2 The Department of Neuroscience, Genentech Incorporated, San Francisco, California 94080 Biological Sciences, Korea Advanced Institute Science Technology, Daejeon 305-701, Correspondence: kime{at}kaist.ac.kr

Language: Английский

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From neural development to cognition: unexpected roles for chromatin

Nature Reviews Genetics, Journal Year: 2013, Volume and Issue: 14(5), P. 347 - 359

Published: April 9, 2013

Language: Английский

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Autism-Associated Neuroligin-3 Mutations Commonly Impair Striatal Circuits to Boost Repetitive Behaviors

Cell, Journal Year: 2014, Volume and Issue: 158(1), P. 198 - 212

Published: July 1, 2014

Language: Английский

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Gene hunting in autism spectrum disorder: on the path to precision medicine

The Lancet Neurology, Journal Year: 2015, Volume and Issue: 14(11), P. 1109 - 1120

Published: April 17, 2015

Language: Английский

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Excitation/Inhibition Imbalance in Animal Models of Autism Spectrum Disorders

Biological Psychiatry, Journal Year: 2016, Volume and Issue: 81(10), P. 838 - 847

Published: May 22, 2016

Imbalances between excitation and inhibition in synaptic transmission neural circuits have been implicated autism spectrum disorders. Excitation imbalances are frequently observed animal models of disorders, their correction normalizes key autistic-like phenotypes these animals. These results suggest that may contribute to the development maintenance disorders represent an important therapeutic target.

Language: Английский

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Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects

Molecular Psychiatry, Journal Year: 2016, Volume and Issue: 22(11), P. 1576 - 1584

Published: July 12, 2016

Autism spectrum disorders (ASDs) are neurodevelopmental caused by various genetic and environmental factors that result in synaptic abnormalities. ASD development is suggested to involve microglia, which have a role refinement during development. Autophagy related pathways also be involved ASDs. However, the precise roles of microglial autophagy synapses ASDs unknown. Here, we show neurobehavior regulation. We found deletion atg7, vital for autophagy, from myeloid cell-specific lysozyme M-Cre mice resulted social behavioral defects repetitive behaviors, characteristic features These had increases dendritic spines markers altered connectivity between brain regions, indicating refinement. Synaptosome degradation was impaired atg7-deficient microglia immature filopodia were increased neurons co-cultured with microglia. To our knowledge, results first regulation synapse neurobehaviors. anticipate starting point more comprehensive studies putative therapeutics.

Language: Английский

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Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

Neuron, Journal Year: 2018, Volume and Issue: 100(6), P. 1322 - 1336.e7

Published: Nov. 1, 2018

Language: Английский

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