BMC Biology,
Journal Year:
2015,
Volume and Issue:
13(1)
Published: Aug. 24, 2015
Astrocytes
can
mediate
neurovascular
coupling,
modulate
neuronal
excitability,
and
promote
synaptic
maturation
remodeling.
All
these
functions
are
likely
to
be
modulated
by
the
sleep/wake
cycle,
because
brain
metabolism,
activity
turnover
change
as
a
function
of
behavioral
state.
Yet,
little
is
known
about
effects
sleep
wake
on
astrocytes.
Here
we
show
that
strongly
affect
both
astrocytic
gene
expression
ultrastructure
in
mouse
brain.
Using
translating
ribosome
affinity
purification
technology
microarrays,
find
1.4
%
all
transcripts
forebrain
dependent
state
(three
groups,
sleep,
wake,
short
deprivation;
six
mice
per
group).
Sleep
upregulates
few
select
genes,
like
Cirp
Uba1,
whereas
many
genes
related
extracellular
matrix
cytoskeleton,
including
Trio,
Synj2
Gem,
which
involved
elongation
peripheral
processes.
serial
block
face
scanning
electron
microscopy
deprivation,
chronic
restriction;
three
group,
>100
spines
mouse,
3D),
hours
sufficient
bring
processes
closer
cleft,
while
restriction
also
extends
overall
coverage
synapse,
at
axon–spine
interface,
increases
available
surface
neuropil.
Wake-related
changes
reflect
an
increased
need
for
glutamate
clearance,
consistent
with
increase
strength
when
prevented.
The
reduced
during
instead,
may
favor
spillover,
thus
promoting
synchronization
non-rapid
eye
movement
sleep.
Cold Spring Harbor Perspectives in Biology,
Journal Year:
2014,
Volume and Issue:
6(9), P. a016428 - a016428
Published: Aug. 7, 2014
Anuja
Mehta
and
James
E.
Haber
Rosenstiel
Basic
Medical
Sciences
Research
Center,
MS029
Brandeis
University,
Waltham,
Massachusetts
02454-9110
Correspondence:
haber{at}brandeis.edu
Neuron,
Journal Year:
2014,
Volume and Issue:
83(2), P. 266 - 282
Published: July 1, 2014
The
integrity
of
our
genetic
material
is
under
constant
attack
from
numerous
endogenous
and
exogenous
agents.
consequences
a
defective
DNA
damage
response
are
well
studied
in
proliferating
cells,
especially
with
regards
to
the
development
cancer,
yet
its
precise
roles
nervous
system
relatively
poorly
understood.
Here
we
attempt
provide
comprehensive
overview
genomic
instability
system.
We
highlight
neuropathology
congenital
syndromes
that
result
mutations
repair
factors
underscore
importance
neural
development.
In
addition,
describe
findings
recent
studies,
which
reveal
robust
also
intimately
connected
aging
manifestation
age-related
neurodegenerative
disorders
such
as
Alzheimer's
disease
amyotrophic
lateral
sclerosis.Video
Abstract/cms/asset/6f0b06d1-6c59-423c-a727-f8e2fde7d3fa/mmc1.mp4Loading
...Download
video
(mp4,
35
MB)
Science,
Journal Year:
2013,
Volume and Issue:
342(6158), P. 632 - 637
Published: Oct. 31, 2013
Not
All
Neurons
Are
Alike
As
life
proceeds,
many
cells
acquire
individualized
mutations.
In
the
immune
system,
genome
rearrangements
generate
useful
antibody
diversity.
McConnell
et
al.
(p.
632
;
see
Perspective
by
Macosko
and
McCarroll
)
now
show
that
human
neurons
also
diversify.
taken
from
postmortem
frontal
cortex
tissue
derived
induced
pluripotent
stem
cell
differentiation
in
vitro
showed
surprising
diversity
individual
genomes.
Up
to
41%
of
had
copy
number
variations—no
two
alike—with
deletions
more
common
than
duplications.
Oncotarget,
Journal Year:
2016,
Volume and Issue:
7(29), P. 44879 - 44905
Published: June 5, 2016
Aging
and
cancer
are
the
most
important
issues
to
research.
The
population
in
world
is
growing
older,
incidence
of
increases
with
age.
There
no
doubt
about
linkage
between
aging
cancer.
However,
molecular
mechanisms
underlying
this
association
still
unknown.
Several
lines
evidence
suggest
that
oxidative
stress
as
a
cause
and/or
consequence
mitochondrial
dysfunction
one
main
drivers
these
processes.
Increasing
ROS
levels
products
stress,
which
occur
age-related
disorders,
were
also
found
This
review
focuses
on
similarities
ageing-associated
cancer-associated
their
common
phenotype.
