Near-infrared fluorophores for biomedical imaging

Nature Biomedical Engineering, Journal Year: 2017, Volume and Issue: 1(1)

Published: Jan. 10, 2017

Language: Английский

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Engrams and circuits crucial for systems consolidation of a memory

Science, Journal Year: 2017, Volume and Issue: 356(6333), P. 73 - 78

Published: April 6, 2017

Episodic memories initially require rapid synaptic plasticity within the hippocampus for their formation and are gradually consolidated in neocortical networks permanent storage. However, engrams circuits that support memory consolidation have thus far been unknown. We found prefrontal engram cells, which critical remote contextual fear memory, were rapidly generated during initial learning through inputs from both hippocampal-entorhinal cortex network basolateral amygdala. After generation, with hippocampal became functionally mature time. Whereas cells silent time, amygdala, necessary maintained. Our data provide new insights into functional reorganization of underlying systems memory.

Language: Английский

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Decoding the organization of spinal circuits that control locomotion

Nature reviews. Neuroscience, Journal Year: 2016, Volume and Issue: 17(4), P. 224 - 238

Published: March 3, 2016

Language: Английский

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Rare-Earth Doping in Nanostructured Inorganic Materials

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(6), P. 5519 - 5603

Published: Jan. 6, 2022

Impurity doping is a promising method to impart new properties various materials. Due their unique optical, magnetic, and electrical properties, rare-earth ions have been extensively explored as active dopants in inorganic crystal lattices since the 18th century. Rare-earth can alter crystallographic phase, morphology, size, leading tunable optical responses of doped nanomaterials. Moreover, control ultimate electronic catalytic performance nanomaterials scalable manner, enabling significant improvements energy harvesting conversion. A better understanding critical role prerequisite for development an extensive repertoire functional practical applications. In this review, we highlight recent advances associated applications many fields. This review covers key criteria doping, including basic structures, lattice environments, strategies, well fundamental design principles that enhance electrical, catalytic, magnetic material. We also discuss future research directions challenges controlling

Language: Английский

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Integration of optogenetics with complementary methodologies in systems neuroscience

Nature reviews. Neuroscience, Journal Year: 2017, Volume and Issue: 18(4), P. 222 - 235

Published: March 17, 2017

Language: Английский

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Emerging Targets in Photopharmacology

Angewandte Chemie International Edition, Journal Year: 2016, Volume and Issue: 55(37), P. 10978 - 10999

Published: July 4, 2016

Abstract The field of photopharmacology uses molecular photoswitches to establish control over the action bioactive molecules. It aims reduce systemic drug toxicity and emergence resistance, while achieving unprecedented precision in treatment. By using small molecules, provides a viable alternative optogenetics. We present here critical overview different pharmacological targets various organs survey organ systems human body that can be addressed non‐invasive manner. discuss prospects for selective delivery light these specific requirements light‐activatable drugs. also aim illustrate druggability medicinal with recent findings emphasize where conceptually new approaches have explored provide future opportunities bring “smart” design ultimately realm clinical use.

Language: Английский

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Novel electrode technologies for neural recordings

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(6), P. 330 - 345

Published: March 4, 2019

Language: Английский

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Multifunctional materials for implantable and wearable photonic healthcare devices

Nature Reviews Materials, Journal Year: 2020, Volume and Issue: 5(2), P. 149 - 165

Published: Jan. 7, 2020

Language: Английский

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Rodent models in neuroscience research: is it a rat race?

Disease Models & Mechanisms, Journal Year: 2016, Volume and Issue: 9(10), P. 1079 - 1087

Published: Oct. 1, 2016

ABSTRACT Rodents (especially Mus musculus and Rattus norvegicus) have been the most widely used models in biomedical research for many years. A notable shift has taken place over last two decades, with mice taking a more prominent role science compared to rats. This was primarily instigated by availability of much larger genetic toolbox mice, particularly embryonic-stem-cell-based targeting technology gene disruption. With recent emergence tools altering rat genome, notably genome-editing technologies, technological gap between organisms is closing, it becoming important consider physiological, anatomical, biochemical pharmacological differences rats when choosing right model system specific biological question. The aim this short review accompanying poster highlight some differences, discuss their impact on studies human diseases, special focus neuropsychiatric disorders.

Language: Английский

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Spatial representation in the hippocampal formation: a history

Nature Neuroscience, Journal Year: 2017, Volume and Issue: 20(11), P. 1448 - 1464

Published: Oct. 26, 2017

Language: Английский

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