Nano Letters,
Journal Year:
2018,
Volume and Issue:
18(7), P. 4148 - 4155
Published: June 19, 2018
Externally
controlling
the
excitation
of
a
neuronal
subset
through
ion
channels
activation
can
modulate
firing
pattern
an
entire
neural
circuit
in
vivo.
As
nanovalves
cell
membrane,
be
opened
by
light
(optogenetics)
or
ultrasonic
(sonogenetics)
means.
A
thoroughly
analyzed
force
sensor
is
Escherichia
coli
mechanosensitive
channel
large
conductance
(MscL).
Here
we
expressed
MscL
rat
hippocampal
neurons
primary
culture
and
showed
that
it
could
activated
low-pressure
ultrasound
pulses.
The
gain-of-function
mutation,
I92L,
sensitized
MscL’s
sonic
response,
triggering
action
potentials
at
peak
negative
pressure
as
low
0.25
MPa.
Further,
I92L
reliably
elicited
individual
spikes
timed
brief
pulses,
making
programmable.
Because
opens
to
tension
lipid
bilayer,
requiring
no
other
proteins
ligands,
developed
into
general
noninvasive
sonogenetic
tool
manipulate
activities
cells
potential
nanodevices.
Clinical Neurophysiology,
Journal Year:
2015,
Volume and Issue:
126(6), P. 1071 - 1107
Published: Feb. 10, 2015
These
guidelines
provide
an
up-date
of
previous
IFCN
report
on
"Non-invasive
electrical
and
magnetic
stimulation
the
brain,
spinal
cord
roots:
basic
principles
procedures
for
routine
clinical
application"
(Rossini
et
al.,
1994).
A
new
Committee,
composed
international
experts,
some
whom
were
in
panel
1994
"Report",
was
selected
to
produce
a
current
state-of-the-art
review
non-invasive
both
application
research
neuroscience.
Since
1994,
scientific
community
has
seen
rapid
increase
brain
studying
cognition,
brain-behavior
relationship
pathophysiology
various
neurologic
psychiatric
disorders.
New
paradigms
techniques
have
been
developed.
Furthermore,
large
number
studies
trials
demonstrated
potential
therapeutic
applications
stimulation,
especially
TMS.
Recent
can
be
found
literature
covering
specific
aspects
such
as
safety
(Rossi
2009),
methodology
(Groppa
2012)
(Lefaucheur
2014).
This
up-dated
covers
theoretical,
physiological
practical
cord,
nerve
roots
peripheral
nerves
light
more
updated
knowledge,
include
recent
extensions
developments.
Science,
Journal Year:
2018,
Volume and Issue:
359(6376), P. 679 - 684
Published: Feb. 9, 2018
Stimulating
deep
inside
the
brain
Noninvasive
stimulation
is
an
important
goal
in
neuroscience
and
neuroengineering.
Optogenetics
normally
requires
use
of
a
blue
laser
inserted
into
brain.
Chen
et
al.
used
specialized
nanoparticles
that
can
upconvert
near-infrared
light
from
outside
local
emission
(see
Perspective
by
Feliu
).
They
injected
these
ventral
tegmental
area
mouse
activated
channelrhodopsin
expressed
dopaminergic
neurons
with
generated
skull
at
distance
several
millimeters.
This
technique
allowed
distant
to
evoke
fast
increases
dopamine
release.
The
method
was
also
successfully
fear
memories
dentate
gyrus
during
conditioning.
Science
,
this
issue
p.
679
;
see
633
Proceedings of the National Academy of Sciences,
Journal Year:
2014,
Volume and Issue:
111(41)
Published: Sept. 29, 2014
Significance
Brain
stimulation
is
a
powerful
treatment
for
an
increasing
number
of
psychiatric
and
neurological
diseases,
but
it
unclear
why
certain
sites
work
or
where
in
the
brain
best
place
to
stimulate
treat
given
patient
disease.
We
found
that
although
different
types
are
applied
locations,
targets
used
same
disease
most
often
nodes
network.
These
results
suggest
networks
might
be
understand
works
improve
therapy
by
identifying
places
brain.
Science,
Journal Year:
2014,
Volume and Issue:
345(6200), P. 1054 - 1057
Published: Aug. 28, 2014
Brain
stimulation
to
improve
human
memory
The
hippocampus
is
a
crucial
brain
area
for
certain
types
of
memory.
Working
with
humans,
Wang
et
al.
found
that
specific
type
non-invasive
improved
tests
and
enhanced
information
flow
between
the
number
other
regions.
This
increased
connectivity
was
highly
individual
target
areas
selected
each
participant.
Science
,
this
issue
p.
1054
Brain stimulation,
Journal Year:
2014,
Volume and Issue:
8(3), P. 499 - 508
Published: Dec. 20, 2014
Periodic
stimulation
of
occipital
areas
using
transcranial
alternating
current
(tACS)
at
alpha
(α)
frequency
(8-12
Hz)
enhances
electroencephalographic
(EEG)
α-oscillation
long
after
tACS-offset.
Two
mechanisms
have
been
suggested
to
underlie
these
changes
in
oscillatory
EEG
activity:
tACS-induced
entrainment
brain
oscillations
and/or
circuits
by
spike-timing
dependent
plasticity.We
tested
what
extent
plasticity
can
account
for
tACS-aftereffects
when
controlling
"echoes."
To
this
end,
we
used
a
novel,
intermittent
tACS
protocol
and
investigated
the
strength
aftereffect
as
function
phase
continuity
between
successive
episodes,
well
match
endogenous
α-frequency.12
healthy
participants
were
stimulated
around
individual
α-frequency
11-15
min
four
sessions
or
sham.
Successive
events
either
phase-continuous
phase-discontinuous,
3
8
s
long.
α-phase
power
compared
episodes
α-tACS
across
conditions
against
sham.α-aftereffects
successfully
replicated
8-s
but
not
3-s
trains.
These
aftereffects
did
reveal
any
characteristics
echoes
that
they
independent
phase-continuity
showed
neither
prolonged
alignment
nor
synchronization
exact
frequency.Our
results
indicate
are
sufficient
explain
α-aftereffects
response
α-tACS,
inform
models
circuits.
Modifying
with
holds
promise
clinical
applications
disorders
involving
abnormal
neural
synchrony.
The Neuroscientist,
Journal Year:
2016,
Volume and Issue:
23(2), P. 109 - 123
Published: Feb. 13, 2016
In
recent
years,
there
has
been
remarkable
progress
in
the
understanding
and
practical
use
of
transcranial
electrical
stimulation
(tES)
techniques.
Nevertheless,
to
date,
this
experimental
effort
not
accompanied
by
substantial
reflections
on
models
mechanisms
that
could
explain
effects.
Given
these
premises,
aim
article
is
provide
an
updated
picture
what
we
know
about
theoretical
tES
have
proposed
contextualized
a
more
specific
unitary
framework.
We
demonstrate
can
behavioral
effects
as
distributed
along
continuum
from
dependent
network
activity
dependent.
framework,
also
propose
stochastic
resonance
useful
mechanism
general
online
neuromodulation
tES.
Moreover,
highlight
aspects
should
be
considered
future
research.
emphasize
“easy-to-use”
technique;
however,
it
may
represent
very
fruitful
approach
if
applied
within
rigorous
protocols,
with
deep
knowledge
both
cognitive
advances
application
stimulation.