Ultrasonic Control of Neural Activity through Activation of the Mechanosensitive Channel MscL DOI
Jia Ye, Siyang Tang, Long Meng

et al.

Nano Letters, Journal Year: 2018, Volume and Issue: 18(7), P. 4148 - 4155

Published: June 19, 2018

Externally controlling the excitation of a neuronal subset through ion channels activation can modulate firing pattern an entire neural circuit in vivo. As nanovalves cell membrane, be opened by light (optogenetics) or ultrasonic (sonogenetics) means. A thoroughly analyzed force sensor is Escherichia coli mechanosensitive channel large conductance (MscL). Here we expressed MscL rat hippocampal neurons primary culture and showed that it could activated low-pressure ultrasound pulses. The gain-of-function mutation, I92L, sensitized MscL’s sonic response, triggering action potentials at peak negative pressure as low 0.25 MPa. Further, I92L reliably elicited individual spikes timed brief pulses, making programmable. Because opens to tension lipid bilayer, requiring no other proteins ligands, developed into general noninvasive sonogenetic tool manipulate activities cells potential nanodevices.

Language: Английский

Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: Basic principles and procedures for routine clinical and research application. An updated report from an I.F.C.N. Committee DOI Creative Commons
Paolo Maria Rossini, David Burke, Robert Chen

et al.

Clinical Neurophysiology, Journal Year: 2015, Volume and Issue: 126(6), P. 1071 - 1107

Published: Feb. 10, 2015

These guidelines provide an up-date of previous IFCN report on "Non-invasive electrical and magnetic stimulation the brain, spinal cord roots: basic principles procedures for routine clinical application" (Rossini et al., 1994). A new Committee, composed international experts, some whom were in panel 1994 "Report", was selected to produce a current state-of-the-art review non-invasive both application research neuroscience. Since 1994, scientific community has seen rapid increase brain studying cognition, brain-behavior relationship pathophysiology various neurologic psychiatric disorders. New paradigms techniques have been developed. Furthermore, large number studies trials demonstrated potential therapeutic applications stimulation, especially TMS. Recent can be found literature covering specific aspects such as safety (Rossi 2009), methodology (Groppa 2012) (Lefaucheur 2014). This up-dated covers theoretical, physiological practical cord, nerve roots peripheral nerves light more updated knowledge, include recent extensions developments.

Language: Английский

Citations

2337

Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics DOI Open Access
Shuo Chen, Adam Z. Weitemier, Xiao Zeng

et al.

Science, Journal Year: 2018, Volume and Issue: 359(6376), P. 679 - 684

Published: Feb. 9, 2018

Stimulating deep inside the brain Noninvasive stimulation is an important goal in neuroscience and neuroengineering. Optogenetics normally requires use of a blue laser inserted into brain. Chen et al. used specialized nanoparticles that can upconvert near-infrared light from outside local emission (see Perspective by Feliu ). They injected these ventral tegmental area mouse activated channelrhodopsin expressed dopaminergic neurons with generated skull at distance several millimeters. This technique allowed distant to evoke fast increases dopamine release. The method was also successfully fear memories dentate gyrus during conditioning. Science , this issue p. 679 ; see 633

Language: Английский

Citations

995

Communication dynamics in complex brain networks DOI
Andrea Avena‐Koenigsberger, Bratislav Mišić, Olaf Sporns

et al.

Nature reviews. Neuroscience, Journal Year: 2017, Volume and Issue: 19(1), P. 17 - 33

Published: Dec. 14, 2017

Language: Английский

Citations

817

Interventions for improving upper limb function after stroke DOI Open Access

Alex Pollock,

Sybil Farmer, Marian Brady

et al.

Cochrane library, Journal Year: 2014, Volume and Issue: 2014(11)

Published: Nov. 12, 2014

Language: Английский

Citations

674

Working memory improvement with non-invasive brain stimulation of the dorsolateral prefrontal cortex: A systematic review and meta-analysis DOI
André R. Brunoni, Marie‐Anne Vanderhasselt

Brain and Cognition, Journal Year: 2014, Volume and Issue: 86, P. 1 - 9

Published: Feb. 8, 2014

Language: Английский

Citations

621

Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases DOI Open Access
Michael Fox, Randy L. Buckner, Hesheng Liu

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2014, Volume and Issue: 111(41)

Published: Sept. 29, 2014

Significance Brain stimulation is a powerful treatment for an increasing number of psychiatric and neurological diseases, but it unclear why certain sites work or where in the brain best place to stimulate treat given patient disease. We found that although different types are applied locations, targets used same disease most often nodes network. These results suggest networks might be understand works improve therapy by identifying places brain.

Language: Английский

Citations

561

Targeted enhancement of cortical-hippocampal brain networks and associative memory DOI
Jane X. Wang,

Lynn M. Rogers,

Evan Z. Gross

et al.

Science, Journal Year: 2014, Volume and Issue: 345(6200), P. 1054 - 1057

Published: Aug. 28, 2014

Brain stimulation to improve human memory The hippocampus is a crucial brain area for certain types of memory. Working with humans, Wang et al. found that specific type non-invasive improved tests and enhanced information flow between the number other regions. This increased connectivity was highly individual target areas selected each participant. Science , this issue p. 1054

Language: Английский

Citations

560

Alpha Power Increase After Transcranial Alternating Current Stimulation at Alpha Frequency (α-tACS) Reflects Plastic Changes Rather Than Entrainment DOI Creative Commons
Alexandra Vossen, Joachim Groß, Gregor Thut

et al.

Brain stimulation, Journal Year: 2014, Volume and Issue: 8(3), P. 499 - 508

Published: Dec. 20, 2014

Periodic stimulation of occipital areas using transcranial alternating current (tACS) at alpha (α) frequency (8-12 Hz) enhances electroencephalographic (EEG) α-oscillation long after tACS-offset. Two mechanisms have been suggested to underlie these changes in oscillatory EEG activity: tACS-induced entrainment brain oscillations and/or circuits by spike-timing dependent plasticity.We tested what extent plasticity can account for tACS-aftereffects when controlling "echoes." To this end, we used a novel, intermittent tACS protocol and investigated the strength aftereffect as function phase continuity between successive episodes, well match endogenous α-frequency.12 healthy participants were stimulated around individual α-frequency 11-15 min four sessions or sham. Successive events either phase-continuous phase-discontinuous, 3 8 s long. α-phase power compared episodes α-tACS across conditions against sham.α-aftereffects successfully replicated 8-s but not 3-s trains. These aftereffects did reveal any characteristics echoes that they independent phase-continuity showed neither prolonged alignment nor synchronization exact frequency.Our results indicate are sufficient explain α-aftereffects response α-tACS, inform models circuits. Modifying with holds promise clinical applications disorders involving abnormal neural synchrony.

Language: Английский

Citations

477

Battery powered thought: Enhancement of attention, learning, and memory in healthy adults using transcranial direct current stimulation DOI
Brian A. Coffman, Vincent P. Clark,

Raja Parasuraman

et al.

NeuroImage, Journal Year: 2013, Volume and Issue: 85, P. 895 - 908

Published: Aug. 8, 2013

Language: Английский

Citations

436

Transcranial Electrical Stimulation DOI Creative Commons
Anna Fertonani, Carlo Miniussi

The Neuroscientist, Journal Year: 2016, Volume and Issue: 23(2), P. 109 - 123

Published: Feb. 13, 2016

In recent years, there has been remarkable progress in the understanding and practical use of transcranial electrical stimulation (tES) techniques. Nevertheless, to date, this experimental effort not accompanied by substantial reflections on models mechanisms that could explain effects. Given these premises, aim article is provide an updated picture what we know about theoretical tES have proposed contextualized a more specific unitary framework. We demonstrate can behavioral effects as distributed along continuum from dependent network activity dependent. framework, also propose stochastic resonance useful mechanism general online neuromodulation tES. Moreover, highlight aspects should be considered future research. emphasize “easy-to-use” technique; however, it may represent very fruitful approach if applied within rigorous protocols, with deep knowledge both cognitive advances application stimulation.

Language: Английский

Citations

413