Neurobiology of relapse to heroin and cocaine seeking: An update and clinical implications

European Journal of Pharmacology, Journal Year: 2005, Volume and Issue: 526(1-3), P. 36 - 50

Published: Nov. 15, 2005

Language: Английский

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Regulation of mitogen‐activated protein kinases by glutamate receptors

Journal of Neurochemistry, Journal Year: 2006, Volume and Issue: 100(1), P. 1 - 11

Published: Aug. 29, 2006

Abstract Glutamate receptors regulate gene expression in neurons by activating intracellular signaling cascades that phosphorylate transcription factors within the nucleus. The mitogen‐activated protein kinase (MAPK) cascade is one of best characterized this regulatory process. Ca 2+ ‐permeable ionotropic glutamate receptor, mainly NMDA receptor subtype, activates MAPKs through a biochemical route involving ‐sensitive Ras‐guanine nucleotide releasing factor, /calmodulin‐dependent II, and phosphoinositide 3‐kinase. metabotropic (mGluR), however, primarily ‐insensitve pathway transactivation tyrosine kinases. adaptor Homer also plays role As an information superhighway between surface nucleus, active specific (Elk‐1 CREB), thereby distinct programs expression. regulated contributes to development multiple forms synaptic plasticity related long‐lasting changes memory function addictive properties drugs abuse. This review, focusing on new data from recent years, discusses mechanisms which different types activate MAPKs, features each MAPK regulating expression, importance glutamate/MAPK‐dependent addiction.

Language: Английский

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Activation of Group II Metabotropic Glutamate Receptors in the Nucleus Accumbens Shell Attenuates Context-Induced Relapse to Heroin Seeking

Neuropsychopharmacology, Journal Year: 2005, Volume and Issue: 31(10), P. 2197 - 2209

Published: Dec. 7, 2005

Language: Английский

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Drugs and alcohol: Treating and preventing abuse, addiction and their medical consequences

Pharmacology & Therapeutics, Journal Year: 2005, Volume and Issue: 108(1), P. 3 - 17

Published: Aug. 12, 2005

Language: Английский

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Incubation of Cue-Induced Cigarette Craving During Abstinence in Human Smokers

Biological Psychiatry, Journal Year: 2010, Volume and Issue: 69(7), P. 708 - 711

Published: Sept. 4, 2010

Language: Английский

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