Social stress induces neurovascular pathology promoting depression

Nature Neuroscience, Journal Year: 2017, Volume and Issue: 20(12), P. 1752 - 1760

Published: Nov. 9, 2017

Language: Английский

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Chronic unpredictable mild stress for modeling depression in rodents: Meta-analysis of model reliability

Neuroscience & Biobehavioral Reviews, Journal Year: 2018, Volume and Issue: 99, P. 101 - 116

Published: Dec. 6, 2018

Language: Английский

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The physical frailty syndrome as a transition from homeostatic symphony to cacophony

Nature Aging, Journal Year: 2021, Volume and Issue: 1(1), P. 36 - 46

Published: Jan. 14, 2021

Language: Английский

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NLRP3 inflammasome-driven pathways in depression: Clinical and preclinical findings

Brain Behavior and Immunity, Journal Year: 2017, Volume and Issue: 64, P. 367 - 383

Published: March 2, 2017

Language: Английский

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Sex Differences in Vulnerability and Resilience to Stress Across the Life Span

Biological Psychiatry, Journal Year: 2019, Volume and Issue: 86(6), P. 421 - 432

Published: May 7, 2019

Language: Английский

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Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation

Frontiers in Psychiatry, Journal Year: 2019, Volume and Issue: 10

Published: March 11, 2019

Early life stressors display a high universal prevalence and constitute major public health problem. Prolonged psychoneurobiological alterations as sequelae of early stress (ELS) could represent developmental risk factor mediate for disease, leading to higher physical mental morbidity rates in later life. ELS exert programming effect on sensitive neuronal brain networks related the response during critical periods development thus lead enduring hyper- or hypo-activation system altered glucocorticoid signaling. In addition, emotional autonomic reactivity, circadian rhythm disruption, functional structural changes brain, well immune metabolic dysregulation have been lately identified important factors chronically impaired homeostatic balance after ELS. Furthermore, human genetic background epigenetic modifications through stress-related gene expression interact with these explain inter-individual variation vulnerability resilience stress. This narrative review presents relevant evidence from mainly research ten most acknowledged neurobiological allostatic pathways exerting adverse effects even decades (hypothalamic-pituitary-adrenal axis, nervous system, inflammation, oxidative stress, cardiovascular gut microbiome, sleep genetics, epigenetics, structural, correlates). Although findings back causal relation between psychobiological maladjustment life, precise trajectories their temporal coincidence has not elucidated yet. Future studies should prospectively investigate putative mediators sequence, while considering potentially delayed time-frame phenotypical expression. Better screening strategies are needed better individual prevention treatment.

Language: Английский

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Resilience and immunity

Brain Behavior and Immunity, Journal Year: 2018, Volume and Issue: 74, P. 28 - 42

Published: Aug. 10, 2018

Resilience is the process that allows individuals to adapt adverse conditions and recover from them. This favored by individual qualities have been amply studied in field of stress such as personal control, positive affect, optimism, social support. Biopsychosocial studies on promote resilience show these factors help protect against deleterious influences stressors physiology general immunity particular. The reverse also true there evidence immune processes influence resilience. Most data supporting this relationship comes animal differences ability resist situations chronic stress. These build knowledge has accumulated brain behavior both human studies. In general, resilient a different immunophenotype susceptible individuals. It possible render vice versa changing their inflammatory phenotype. adaptive phenotype inflammation-induced symptoms. modulation bidirectional relationships between gut microbiota opens possibility them probiotics prebiotics. However, more focused reciprocal will be necessary before can put into practice.

Language: Английский

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Molecular adaptations of the blood–brain barrier promote stress resilience vs. depression

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(6), P. 3326 - 3336

Published: Jan. 23, 2020

Significance Thirty to fifty percent of depressed individuals are unresponsive commonly prescribed antidepressant treatments, suggesting that biological mechanisms, such as stress-induced inflammation and blood vessel dysfunction, remain untreated. The blood–brain barrier is the ultimate frontier between brain harmful toxins or inflammatory signals circulating in blood. Depression vulnerability chronic social stress associated with loss this integrity; however, mechanisms involved poorly understood. Identification adaptations leading resilience under stressful conditions could help develop novel treatments. Here we combined behavioral, pharmacological, cell-specific gene profiling experiments mice epigenetic, molecular, anatomical analysis human samples unravel therapeutic potential protect promote resilience.

Language: Английский

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Breath of Life: The Respiratory Vagal Stimulation Model of Contemplative Activity

Frontiers in Human Neuroscience, Journal Year: 2018, Volume and Issue: 12

Published: Oct. 9, 2018

Contemplative practices, such as meditation and yoga, are increasingly popular among the general public topics of research. Beneficial effects associated with these practices have been found on physical health, mental health cognitive performance. However, studies theories that clarify underlying mechanisms lacking or scarce. This theoretical review aims to address compensate this scarcity. We will show various contemplative activities in common breathing is regulated attentively guided. respiratory discipline turn could parsimoniously explain benefits through changes autonomic balance. propose a neurophysiological model explains how specific respiration styles operate, by phasically tonically stimulating vagal nerve: nerve stimulation (rVNS). The nerve, proponent parasympathetic nervous system (PNS), prime candidate explaining cognition. discuss implications limitations our model.

Language: Английский

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IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis

Science Advances, Journal Year: 2021, Volume and Issue: 7(12)

Published: March 17, 2021

Adult neurogenesis in the dentate gyrus of hippocampus is regulated by specific microglia groups and functionally implicated behavioral responses to stress. However, role hippocampal stress resilience remains unclear. We identified interleukin 4 (IL4)-driven characterized high expression Arg1, which critical maintaining resistance. Decreasing Arg1+ knocking down microglial IL4R suppressed enhanced vulnerability. Increasing enhancing IL4 signaling restored stress-induced depression. Brain-derived neurotrophic factor (BDNF) was found necessary for proneurogenesis effects IL4-driven microglia. Together, our findings suggest that trigger BDNF-dependent responding chronic stress, helping protect against depressive-like symptoms. These identify modulation a phenotype as treatment strategy mood disorders.

Language: Английский

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