Immunogenic cell death in cancer and infectious disease

Nature reviews. Immunology, Journal Year: 2016, Volume and Issue: 17(2), P. 97 - 111

Published: Oct. 17, 2016

Language: Английский

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CD4+ T cell help in cancer immunology and immunotherapy

Nature reviews. Immunology, Journal Year: 2018, Volume and Issue: 18(10), P. 635 - 647

Published: July 29, 2018

Language: Английский

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Therapeutic cancer vaccines

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(6), P. 360 - 378

Published: April 27, 2021

Language: Английский

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Therapeutic cancer vaccines

Journal of Clinical Investigation, Journal Year: 2015, Volume and Issue: 125(9), P. 3401 - 3412

Published: July 27, 2015

The clinical benefit of therapeutic cancer vaccines has been established. Whereas regression lesions was shown for premalignant caused by HPV, in patients mostly noted as prolonged survival. Suboptimal vaccine design and an immunosuppressive microenvironment are the root causes lack eradication. Effective deliver concentrated antigen to both HLA class I II molecules DCs, promoting CD4 CD8 T cell responses. Optimal platforms include DNA RNA synthetic long peptides. Antigens choice mutant sequences, selected testis antigens, viral antigens. Drugs or physical treatments can mitigate chemotherapeutics, radiation, indoleamine 2,3-dioxygenase (IDO) inhibitors, inhibitors checkpoints, agonists TNF receptor family members, undesirable cytokines. specificity vaccination combined with such immunomodulation offers attractive avenue development future therapies.

Language: Английский

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Engineered T cells: the promise and challenges of cancer immunotherapy

Nature reviews. Cancer, Journal Year: 2016, Volume and Issue: 16(9), P. 566 - 581

Published: Aug. 23, 2016

Language: Английский

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Turning the corner on therapeutic cancer vaccines

npj Vaccines, Journal Year: 2019, Volume and Issue: 4(1)

Published: Feb. 8, 2019

Abstract Recent advances in several areas are rekindling interest and enabling progress the development of therapeutic cancer vaccines. These have been made target selection, vaccine technology, methods for reversing immunosuppressive mechanisms exploited by cancers. Studies testing different tumor antigens revealed properties that yield high versus normal cell specificity adequate immunogenicity to affect clinical efficacy. A few tumor-associated antigens, host proteins abnormally expressed cells, demonstrated serve as good targets immunotherapies, although many do not possess needed or immunogenicity. Neoantigens, which arise from mutated truly cancer-specific can be highly immunogenic, though vast majority unique each patient’s thus require personalized therapies. Lessons previous expeditions teaching us type magnitude immune responses needed, well technologies achieve these responses. For example, we learning approaches elicit potent, balanced, durable CD4 plus CD8 T expansion necessary Exploration interactions between system has elucidated adaptations enable cells suppress evade attack. This led breakthroughs new drugs, and, subsequently, opportunities combine with vaccines dramatically increase patient Here review this recent progress, highlighting key steps bringing promise within reach.

Language: Английский

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Turning cold tumors into hot tumors by improving T-cell infiltration

Theranostics, Journal Year: 2021, Volume and Issue: 11(11), P. 5365 - 5386

Published: Jan. 1, 2021

Immunotherapy, represented by immune checkpoint inhibitors (ICIs), has greatly improved the clinical efficacy of malignant tumor therapy. ICI-mediated antitumor responses depend on infiltration T cells capable recognizing and killing cells. ICIs are not effective in "cold tumors", which characterized lack T-cell infiltration. To realize full potential immunotherapy solve this obstacle, it is essential to understand drivers into tumors. We present a critical review our understanding mechanisms underlying including impaired priming deficient homing beds. "Hot tumors" with significant associated better ICI efficacy. In review, we summarize multiple strategies that promote transformation "hot discuss these lead increased Finally, application nanomaterials provide an outlook future emerging field. The combination nanomedicines enhances cross-presentation antigens promotes A deeper opens new possibilities for development cell-based therapies improve effectiveness.

Language: Английский

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Cancer immunotherapy: Opportunities and challenges in the rapidly evolving clinical landscape

European Journal of Cancer, Journal Year: 2017, Volume and Issue: 81, P. 116 - 129

Published: June 16, 2017

Language: Английский

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Regulation of the host immune system by helminth parasites

Journal of Allergy and Clinical Immunology, Journal Year: 2016, Volume and Issue: 138(3), P. 666 - 675

Published: July 30, 2016

Helminth parasite infections are associated with a battery of immunomodulatory mechanisms that affect all facets the host immune response to ensure their persistence within host. This broad-spectrum modulation immunity has intended and unintended consequences, both advantageous disadvantageous. Thus can benefit from suppression collateral damage during infection reduced allergic, autoimmune, inflammatory reactions. However, helminth also be detrimental in reducing vaccine responses, increasing susceptibility coinfection potentially tumor immunosurveillance. In this review we will summarize panoply used by helminths, potential utility human disease, prospective areas future research. Discuss article on JACI Journal Club blog: www.jaci-online.blogspot.com. Helminths highly prevalent metazoan worm parasites, which have evolved spectrum sophisticated means regulate evade system.1McSorley H.J. Maizels R.M. regulation.Clin Microbial Rev. 2012; 25: 585-608Crossref PubMed Scopus (0) Google Scholar appear act as successful xenotransplants into mammalian body, neutralizing pathways would otherwise expel them resetting thresholds reactivity.2Johnston C.J. McSorley Anderton S.M. Wigmore S.J. immunological tolerance.Transplantation. 2014; 97: 127-132Crossref (15) so doing, they dampen responses unrelated bystander specificities, such allergens autoantigens, manner might fact host.1McSorley Scholar, 3Mishra P.K. Palma M. Bleich D. Loke P. Gause W.C. Systemic impact intestinal infections.Mucosal Immunol. 7: 753-762Crossref (39) Only dozen or species helminths widespread subjects, but together, infect some 2 billion persons, nearly one third population.4Hotez P.J. Brindley Bethony J.M. King C.H. Pearce E.J. Jacobson J. infections: great neglected tropical diseases.J Clin Invest. 2008; 118: 1311-1321Crossref (660) Their extraordinary prevalence bears witness success at defeating defenses suggests much learn how these parasites modulate our own system. Although establish range tissue niches, cases do not multiply produce eggs larvae new hosts; hence tend stable chronic endure for surprisingly long (up 20 years) an individual setting almost every facet system is modified even recalibrated, infected subjects displaying state hyporesponsiveness considered form immunologic tolerance.5Nutman T.B. Kumaraswami V. Ottesen E.A. Parasite-specific anergy filariasis. Insights after analysis antigen-driven lymphokine production.J 1987; 79: 1516-1523Crossref 6Maizels Lawrence R.A. Immunological tolerance: key feature filariasis?.Parasitol Today. 1991; 271-276Abstract Full Text PDF 7King C.L. Poindexter R.W. Kumari S. Jayaraman K. Alling D.W. et al.Immunologic tolerance lymphatic Diminished parasite-specific T B cell lymphocyte precursor frequency microfilaremic state.J 1992; 89: 1403-1410Crossref Immunologic was first seen through muted antigen-specific T-cell patients' PBMC cultures.7King 8Piessens W.F. McGreevy P.B. Piessens P.W. Koiman I. Saroso J.S. al.Immune Brugia malayi. Specific cellular unresponsiveness filarial antigens.J 1980; 65: 172-179Crossref 9Colley D.G. Garcia A.A. Lambertucci J.R. Parra J.C. Katz N. Rocha R.S. schistosomiasis. XII. Differential responsiveness patients hepatosplenic disease.Am J Trop Med Hyg. 1986; 35: 793-802Crossref 10Sartono E. Kruize Y.C.M. Kurniawan A. van der Meide P.H. Partono F. al.Elevated interferon-γ release long-term diethylcarbamazine treatment filariasis.J Infect Dis. 1995; 171: 1683-1687Crossref particular, specific asymptomatic carriers rather than those progressive pathologic manifestations, elephantiasis. Furthermore, anthelminthic drug clearance hyporesponsive resulted recovery suggesting were actively inhibited presence helminths.10Sartono 11Grogan J.L. Kremsner P.G. Deelder A.M. Yazdanbakhsh Elevated proliferation interleukin-4 CD4+ cells chemotherapy Schistosoma haematobium infection.Eur 1996; 26: 1365-1370Crossref addition, helminth-infected show skewed cytokine profiles, favoring IL-4 over IL-17 IFN-γ10Sartono more conspicuous IL-10 TGF-β components.12Mahanty Mollis S.N. Ravichandran Abrams al.High levels spontaneous interleukin-10 production 173: 769-773Crossref 13Doetze Satoguina Burchard G. Rau T. Loliger C. Fleischer B. al.Antigen-specific mediated Th3/Tr1-type cytokines transforming growth factor-b Th1 Th2 shift.Int 2000; 12: 623-630Crossref contrast, whom symptomatic disease develops, there failure tolerance, allowing TH1 TH17 surface mediate significant pathology tissues.14Mbow Larkin B.M. Meurs L. Wammes L.J. de Jong S.E. Labuda L.A. al.T-helper 17 schistosomiasis.J 2013; 207: 186-195Crossref 15Babu Bhat S.Q. Pavan Kumar Lipira A.B. Karthik al.Filarial lymphedema characterized Th17 proinflammatory lack regulatory cells.PLoS Negl 2009; 3: e420Crossref homeostatic self-antigens harmless environmental antigens (including commensal bacteria food components) primarily maintained immunosuppressive subset, (Treg) cell.16Sakaguchi Regulatory cells: controllers self-tolerance.Cell. 101: 455-458Abstract As discussed below, strong link emerged between Treg activity, particularly state.17Maizels Smith K.A. infection.Adv 2011; 112: 73-136Crossref 18Ludwig-Portugall Layland L.E. TLRs, Treg, cells, interplay regulation infection.Front 8Crossref (14) 19Metenou Nutman subsets function.Front 4: 305Crossref (23) Immune downregulation further extends many local systemic settings, variety specificities.3Mishra One example polyclonal childhood vaccines compromised heavily subjects.20Labeaud A.D. Malhotra M.J. Do antenatal devalue vaccination?.PLoS e442Crossref (101) undermine against other major pathogens, Mycobacterium tuberculosis.3Mishra 21Salgame Yap G.S. Effect helminth-induced microbial pathogens.Nat 14: 1118-1126Crossref (89) case malaria, however, consequences nuanced, evidence increased combined moderated attenuated severity.22Hartgers F.C. Obeng B.B. Y.C. Dijkhuis McCall Sauerwein al.Responses malarial altered children.J 199: 1528-1535Crossref 23Dolo H. Coulibaly Y.I. Dembele Konate S.Y. Doumbia S.S. al.Filariasis attenuates anemia clinical malaria: matched study children young adults.PLoS 6: e1890Crossref The delicate balance inflammation exemplified cysticercosis, neurological caused Taenia solium cysts.24Nash T.E. H.H. Diagnosis neurocysticercosis.Nat Rev Neurol. 584-594Crossref It well recognized dampened immunoregulatory underpin phase disease.25Verma Prasad K.N. Cheekatla Nyati K.K. Paliwal V.K. Gupta R.K. neurocysticercosis.Med Microbiol 200: 255-261Crossref most disseminated actually greatest degree immunoregulation, levels, decreased TH2 trend numbers.26Tuero Cabeza Saleemi Rodriguez Gonzales al.A comparative peripheral individuals parenchymal subarachnoid neurocysticercosis.PLoS 2015; 9: e0004143Crossref finely poised: immunomodulation leads dissemination parasite, whereas causes seizures death. clearly naive adult model systems, endemic settings it common offspring born mothers, become very early age, both. Maternal boosts newborn, Haitian mothers Wuchereria bancrofti 2- 3-fold likely themselves while showing lower level reactivity uninfected mothers.27Lammie Hitch W.L. Walker Allen E.M. Hightower W. Eberhard M.L. risk factor children.Lancet. 337: 1005-1006Abstract remarkable Cook Islands, confirmed years mounted substantially weaker antigens.28Steel Guinea McCarthy Long-term effect prenatal exposure maternal microfilaraemia antigens.Lancet. 1994; 343: 890-893Abstract Hence seems experience utero tolerization antigens. affects reactivities subjects29Mpairwe Tweyongyere R. Elliott Pregnancy infections.Parasite 36: 328-337Crossref experimental models, airway allergy.30Straubinger Paul Prazeres da Costa O. Ritter Buch Busch D.H. al.Maternal pregnancy determines allergic inflammation.J Allergy 134: 1271-1279.e10Abstract further, anti-inflammatory effects observed only allergy context autoimmunity transplantation reactions.2Johnston 31Weinstock J.V. D.E. decrease immune-mediated 193: 3239-3247Crossref 32Li Y. Chen H.L. Bannick Henry Holm A.N. Metwali al.Intestinal lethal acute graft-versus-host preserve graft-versus-tumor mice.J 194: 1011-1020Crossref A association expansion populations, importantly subset.17Maizels 33Finlay C.M. Walsh K.P. Mills K.H. Induction parasites: exploitation diseases.Immunol 259: 206-230Crossref (58) expressing transcription forkhead box protein 3 (Foxp3) numerous active anthelmintic chemotherapy.19Metenou 34Watanabe Mwinzi P.N. Black Muok Karanja D.M. Secor W.E. al.T people mansoni effective treatment.Am 2007; 77: 676-682PubMed 35Wammes Hamid Wiria A.E. Wibowo Sartono al.Regulatory filariasis: stronger functional activity microfilaremics.PLoS e1655Crossref (28) pathologies, elephantiasis hyperreactive onchocerciasis, diminished compared unresponsive carriers, supporting argument compartment maintains prevents infections.15Babu 36Metenou Dolo al.At homeostasis expanded adaptive classical cells.J 2010; 184: 5375-5382Crossref 37Katawa Debrah A.Y. von Horn Batsa Kwarteng al.Hyperreactive onchocerciasis combination Th17-Th2 e3414Crossref Likewise, soil-transmitted nematode infections, similar profile production, antigen evident.38Turner J.D. Jackson J.A. Faulkner Behnke Else Kamgno al.Intensity multiple related output hyporesponsiveness.J 197: 1204-1212Crossref (65) 39Figueiredo C.A. Barreto Rodrigues L.C. Cooper Silva N.B. Amorim L.D. al.Chronic induction network.Infect Immun. 78: 3160-3167Crossref (92) Mechanistically, implicated involving TGF-β, cell-surface interactions cytotoxic lymphocyte–associated 4 programmed death-1.19Metenou 38Turner 40Satoguina Mempel Larbi Badusche Löliger Adjei regulatory-1 immunosuppression (onchocerciasis).Microbes Infect. 2002; 1291-1300Crossref correlate closely isotype switch proallergic/inflammatory IgE noninflammatory IgG441Satoguina Weyand Hoerauf induce IgG4 role IL-10.J 2005; 174: 4718-4726Crossref Scholar; Foxp3− TR1 predominant source IL-10,36Metenou although Foxp3+ present, contribute driving subjects.42Satoguina Adjobimey Arndts Hoch Oldenburg al.Tr1 naturally occurring GITR/GITR-L interaction, TGF-β.Eur 38: 3101-3113Crossref Serum largely composed mixed dimers. Because heavy chains linking disulfide bonds, exchange molecules; molecules functionally monovalent noninflammatory.43van Neut Kolfschoten Schuurman Losen Bleeker W.K. Martinez-Martinez Vermeulen al.Anti-inflammatory antibodies dynamic Fab arm exchange.Science. 317: 1554-1557Crossref (474) Drug sharp decreases circulating again arguing press favor isotype.44Grogan Dam G.J. Metzger Mordmüller al.Antischistosome affected differentially versus adults.J 1242-1247Crossref causal links now been established directions. First, certain directly drive host45Grainger Hewitson J.P. Harcus Filbey K.J. al.Helminth secretions novo Foxp3 expression function pathway.J Exp Med. 2331-2341Crossref (258) indirectly inducing promotes function.46Zaccone Burton Miller Jones F.M. Dunne Cooke egg participate diabetes prevention NOD mice.Eur 39: 1098-1107Crossref (110) simply corollary must accompany prevent overreaction. Second, essential survive immunocompetent because depletion mouse systems results infection,47Blankenhaus Klemm U. Eschbach Sparwasser Huehn Kuhl al.Strongyloides ratti induces interfere BALB/c 186: 4295-4305Crossref 48Sawant D.V. Gravano Vogel Giacomin Artis Vignali D.A.A. limit protective promote following infection.J 192: 2904-2912Crossref (19) 49Smith Reynolds Boon al.Low type-2 effector gastrointestinal helminths.Mucosal 2016; 428-443Crossref IL-2 administration renders mice susceptible.49Smith Interestingly, filariasis, population, tissue-dwelling requires ablation restimulation population.50Taylor Le Goff Harris Malone J.E. Removal reverses vivo.J 4924-4933Crossref 51Taylor M.D. Werf infection: regulators regulated.Trends 33: 181-189Abstract (83) murine mirror ways. For example, instrumental attenuation nematodes52Wilson M.S. Taylor Balic Finney C.A.M. Lamb Suppression 202: 1199-1212Crossref (412) schistosomes.53Layland Straubinger Loffredo-Verde Garn al.Schistosoma mansoni-mediated patency e2379Crossref They play vital protecting exacerbate results.48Sawant 54D'Elia Bradley control driven survival.J 182: 2340-2348Crossref partial strengthen required expulsion, total absence storm prevails, preventing coherent response.49Smith weakened vitro proliferative BCG malaria recover if removed test cultures.55Wammes Gier geohelminth suppress Plasmodium falciparum.Eur 40: 437-442Crossref Similarly, vaccination elicits poor purified derivative contrast production; scenario, interference due cytokines.56Elias Britton Aseffa Engers Akuffo Poor immunogenicity population production.Vaccine. 3897-3902Crossref Supporting this, recent reported tuberculosis-infected migrants United Kingdom who coinfected had higher frequencies tuberculosis alone numbers populations.57Toulza Tsang Ottenhoff T.H. Brown Dockrell H.M. tuberculosis-specific increased, decreased, anthelmintic-treated latent TB.Eur 46: 752-761Crossref Often overshadowed counterparts, (Breg) crucially important infection.58Hussaarts Vlugt Smits B-cell helminths: implications disease.J 128: 733-739Abstract (78) Heligmosomoides polygyrus–infected autoimmune encephalomyelitis when transferred recipient mice.59Wilson O'Gorman M.T. Barr T.A. al.Helminth-induced CD19+CD23hi inflammation.Eur 1682-1

Language: Английский

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Targeting drugs to tumours using cell membrane-coated nanoparticles

Nature Reviews Clinical Oncology, Journal Year: 2022, Volume and Issue: 20(1), P. 33 - 48

Published: Oct. 28, 2022

Language: Английский

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