Targeting apoptosis in cancer therapy

Nature Reviews Clinical Oncology, Journal Year: 2020, Volume and Issue: 17(7), P. 395 - 417

Published: March 23, 2020

Language: Английский

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Lung cancer

The Lancet, Journal Year: 2021, Volume and Issue: 398(10299), P. 535 - 554

Published: July 21, 2021

Language: Английский

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Comprehensive review of targeted therapy for colorectal cancer

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: March 20, 2020

Abstract Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in world was responsible for nearly 881,000 cancer-related deaths 2018. Surgery chemotherapy have long been first choices patients. However, prognosis of CRC has never satisfying, especially patients with metastatic lesions. Targeted therapy a new optional approach that successfully prolonged overall survival Following successes anti-EGFR (epidermal growth factor receptor) agent cetuximab anti-angiogenesis bevacizumab, agents blocking different critical pathways as well immune checkpoints are emerging at an unprecedented rate. Guidelines worldwide currently updating recommended targeted drugs on basis increasing number high-quality clinical trials. This review provides overview existing CRC-targeted their underlying mechanisms, discussion limitations future trends.

Language: Английский

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Toward personalized treatment approaches for non-small-cell lung cancer

Nature Medicine, Journal Year: 2021, Volume and Issue: 27(8), P. 1345 - 1356

Published: Aug. 1, 2021

Language: Английский

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Tumour-targeting bacteria engineered to fight cancer

Nature reviews. Cancer, Journal Year: 2018, Volume and Issue: 18(12), P. 727 - 743

Published: Nov. 7, 2018

Language: Английский

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Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing

Cell, Journal Year: 2020, Volume and Issue: 182(5), P. 1232 - 1251.e22

Published: Aug. 20, 2020

Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables adaptability, limits therapeutic success, and remains incompletely understood. Single-cell RNA sequencing (scRNA-seq) metastatic lung was performed using 49 clinical biopsies obtained from 30 patients before during targeted therapy. Over 20,000 tumor microenvironment (TME) single-cell profiles exposed a rich dynamic ecosystem. scRNA-seq cells illuminated targetable oncogenes beyond those detected clinically. Cancer surviving therapy as residual disease (RD) expressed an alveolar-regenerative cell signature suggesting therapy-induced primitive cell-state transition, whereas present at on-therapy progressive (PD) upregulated kynurenine, plasminogen, gap-junction pathways. Active T-lymphocytes decreased macrophages were RD immunosuppressive states characterized PD. Biological features revealed by biomarkers outcomes in independent cohorts. This study highlights how adaptation multi-cellular ecosystem shapes outcomes.

Language: Английский

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Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies

Immunity, Journal Year: 2018, Volume and Issue: 48(3), P. 417 - 433

Published: March 1, 2018

Language: Английский

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Integrative Proteomic Characterization of Human Lung Adenocarcinoma

Cell, Journal Year: 2020, Volume and Issue: 182(1), P. 245 - 261.e17

Published: July 1, 2020

Language: Английский

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How Machine Learning Will Transform Biomedicine

Cell, Journal Year: 2020, Volume and Issue: 181(1), P. 92 - 101

Published: April 1, 2020

Language: Английский

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TATTON: a multi-arm, phase Ib trial of osimertinib combined with selumetinib, savolitinib, or durvalumab in EGFR-mutant lung cancer

Annals of Oncology, Journal Year: 2020, Volume and Issue: 31(4), P. 507 - 516

Published: March 2, 2020

Language: Английский

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