
Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)
Published: Jan. 21, 2022
RNA demethylase ALKBH5 takes part in the modulation of N
Language: Английский
Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)
Published: Jan. 21, 2022
RNA demethylase ALKBH5 takes part in the modulation of N
Language: Английский
Nature Reviews Clinical Oncology, Journal Year: 2020, Volume and Issue: 17(7), P. 395 - 417
Published: March 23, 2020
Language: Английский
Citations
1952The Lancet, Journal Year: 2021, Volume and Issue: 398(10299), P. 535 - 554
Published: July 21, 2021
Language: Английский
Citations
1704Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)
Published: March 20, 2020
Abstract Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in world was responsible for nearly 881,000 cancer-related deaths 2018. Surgery chemotherapy have long been first choices patients. However, prognosis of CRC has never satisfying, especially patients with metastatic lesions. Targeted therapy a new optional approach that successfully prolonged overall survival Following successes anti-EGFR (epidermal growth factor receptor) agent cetuximab anti-angiogenesis bevacizumab, agents blocking different critical pathways as well immune checkpoints are emerging at an unprecedented rate. Guidelines worldwide currently updating recommended targeted drugs on basis increasing number high-quality clinical trials. This review provides overview existing CRC-targeted their underlying mechanisms, discussion limitations future trends.
Language: Английский
Citations
1333Nature Medicine, Journal Year: 2021, Volume and Issue: 27(8), P. 1345 - 1356
Published: Aug. 1, 2021
Language: Английский
Citations
718Nature reviews. Cancer, Journal Year: 2018, Volume and Issue: 18(12), P. 727 - 743
Published: Nov. 7, 2018
Language: Английский
Citations
631Cell, Journal Year: 2020, Volume and Issue: 182(5), P. 1232 - 1251.e22
Published: Aug. 20, 2020
Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables adaptability, limits therapeutic success, and remains incompletely understood. Single-cell RNA sequencing (scRNA-seq) metastatic lung was performed using 49 clinical biopsies obtained from 30 patients before during targeted therapy. Over 20,000 tumor microenvironment (TME) single-cell profiles exposed a rich dynamic ecosystem. scRNA-seq cells illuminated targetable oncogenes beyond those detected clinically. Cancer surviving therapy as residual disease (RD) expressed an alveolar-regenerative cell signature suggesting therapy-induced primitive cell-state transition, whereas present at on-therapy progressive (PD) upregulated kynurenine, plasminogen, gap-junction pathways. Active T-lymphocytes decreased macrophages were RD immunosuppressive states characterized PD. Biological features revealed by biomarkers outcomes in independent cohorts. This study highlights how adaptation multi-cellular ecosystem shapes outcomes.
Language: Английский
Citations
542Immunity, Journal Year: 2018, Volume and Issue: 48(3), P. 417 - 433
Published: March 1, 2018
Language: Английский
Citations
502Cell, Journal Year: 2020, Volume and Issue: 182(1), P. 245 - 261.e17
Published: July 1, 2020
Language: Английский
Citations
461Cell, Journal Year: 2020, Volume and Issue: 181(1), P. 92 - 101
Published: April 1, 2020
Language: Английский
Citations
426Annals of Oncology, Journal Year: 2020, Volume and Issue: 31(4), P. 507 - 516
Published: March 2, 2020
Language: Английский
Citations
356