Single-cell and spatial transcriptomics analysis of non-small cell lung cancer DOI Creative Commons
Marco De Zuani, Haoliang Xue, Jun Sung Park

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 23, 2024

Abstract Lung cancer is the second most frequently diagnosed and leading cause of cancer-related mortality worldwide. Tumour ecosystems feature diverse immune cell types. Myeloid cells, in particular, are prevalent have a well-established role promoting disease. In our study, we profile approximately 900,000 cells from 25 treatment-naive patients with adenocarcinoma squamous-cell carcinoma by single-cell spatial transcriptomics. We note an inverse relationship between anti-inflammatory macrophages NK cells/T reduced cytotoxicity within tumour. While observe similar type composition both carcinoma, detect significant differences co-expression various checkpoint inhibitors. Moreover, reveal evidence transcriptional “reprogramming” tumours, shifting them towards cholesterol export adopting foetal-like signature which promotes iron efflux. Our multi-omic resource offers high-resolution molecular map tumour-associated macrophages, enhancing understanding their tumour microenvironment.

Language: Английский

Third-generation EGFR and ALK inhibitors: mechanisms of resistance and management DOI
Alissa J. Cooper, Lecia V. Sequist, W. Marston Linehan

et al.

Nature Reviews Clinical Oncology, Journal Year: 2022, Volume and Issue: 19(8), P. 499 - 514

Published: May 9, 2022

Language: Английский

Citations

300
Lung cancer statistics, 2023 DOI
Tyler B. Kratzer, Priti Bandi, Neal D. Freedman

et al.

Cancer, Journal Year: 2024, Volume and Issue: 130(8), P. 1330 - 1348

Published: Jan. 27, 2024

Abstract Despite decades of declining mortality rates, lung cancer remains the leading cause death in United States. This article examines incidence, stage at diagnosis, survival, and using population‐based data from National Cancer Institute, Centers for Disease Control Prevention, North American Association Central Registries. Over past 5 years, declines became considerably greater than incidence among men (5.0% vs. 2.6% annually) women (4.3% 1.1% annually), reflecting absolute gains 2‐year relative survival 1.4% annually. Improved outcomes likely reflect advances treatment, increased access to care through Patient Protection Affordable Care Act, earlier diagnosis; example, compared with a 4.6% annual decrease distant‐stage disease during 2013–2019, rate localized‐stage rose by 3.6% Localized more steeply states highest screening prevalence (by 3%–5% those lowest 1%–2% annually). progress, disparities remain. For Native Americans have slowest decline (less 1% annually stagnant rates women) any group. In addition, Mississippi Kentucky are two three times higher most western states, largely because elevated historic smoking that remains. Racial geographic inequalities highlight longstanding opportunities concerted tobacco‐control efforts targeted high‐risk populations, including improved smoking‐cessation treatments screening, as well state‐of‐the‐art treatment.

Language: Английский

Citations

182
Bacteria in cancer initiation, promotion and progression DOI
Geniver El Tekle, Wendy S. Garrett

Nature reviews. Cancer, Journal Year: 2023, Volume and Issue: 23(9), P. 600 - 618

Published: July 3, 2023

Language: Английский

Citations

155
VEGF/VEGFR-Targeted Therapy and Immunotherapy in Non-small Cell Lung Cancer: Targeting the Tumor Microenvironment DOI Creative Commons
Yueshui Zhao,

Sipeng Guo,

Jian Min Deng

et al.

International Journal of Biological Sciences, Journal Year: 2022, Volume and Issue: 18(9), P. 3845 - 3858

Published: Jan. 1, 2022

Non-small cell lung cancer (NSCLC) is the leading cause of death by worldwide.Despite developments in therapeutic approaches for past few decades, 5-year survival rate patients with NSCLC remains low.NSCLC tumor a complex, heterogeneous microenvironment, comprising blood vessels, cells, immune and stroma cells.Vascular endothelial growth factors (VEGFs) are major mediator to induce microvasculature associated progression, recurrence, metastasis NSCLC.Current treatment medicines targeting VEGF/VEGF receptor (VEGFR) pathway, including neutralizing antibodies VEGF or VEGFR tyrosine kinase inhibitors, have shown good efficacy NSCLC.VEGF not only an important angiogenic factor but also immunomodulator microenvironment (TME).VEGFs can suppress antigen presentation, stimulate activity regulatory T (Treg) tumor-associated macrophages, which turn promote suppressive NSCLC.The present review focuses on non-angiogenic functions NSCLC, especially interaction between cellular components TME.Additionally, we discuss recent preclinical clinical studies explore VEGF/VEGFR-targeted compounds immunotherapy as novel TME NSCLC.

Language: Английский

Citations

133
Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer: Progress, Challenges, and Prospects DOI Creative Commons
Shengjie Tang, Chao Qin, Haiyang Hu

et al.

Cells, Journal Year: 2022, Volume and Issue: 11(3), P. 320 - 320

Published: Jan. 19, 2022

Non-small cell lung cancer is one of the most common types malignances worldwide and main cause cancer-related deaths. Current treatment for NSCLC based on surgical resection, chemotherapy, radiotherapy, targeted therapy, with poor therapeutic effectiveness. In recent years, immune checkpoint inhibitors have applied in treatment. A large number experimental studies shown that are safer more effective than traditional modalities allowed development better guidance clinical advanced patients. this review, we describe trials using ICI immunotherapies treatment, available data efficacy, emerging evidence regarding biomarkers.

Language: Английский

Citations

130
Syndrome of Combined Pulmonary Fibrosis and Emphysema: An Official ATS/ERS/JRS/ALAT Research Statement DOI
Vincent Cottin, Moisés Selman, Yoshikazu Inoue

et al.

American Journal of Respiratory and Critical Care Medicine, Journal Year: 2022, Volume and Issue: 206(4), P. e7 - e41

Published: Aug. 15, 2022

Section:ChooseTop of pageAbstract <

Language: Английский

Citations

113
The heterogeneous immune landscape between lung adenocarcinoma and squamous carcinoma revealed by single-cell RNA sequencing DOI Creative Commons
Chengdi Wang,

Qiuxiao Yu,

Tingting Song

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Aug. 26, 2022

Abstract A thorough interrogation of the immune landscape is crucial for immunotherapy strategy selection and prediction clinical responses in non-small-cell lung cancer (NSCLC) patients. Single-cell RNA sequencing (scRNA-seq) techniques have prompted opportunity to dissect distinct signatures between adenocarcinoma (LUAD) squamous cell carcinoma (LUSC), two major subtypes NSCLC. Here, we performed scRNA-seq on 72,475 cells from 40 samples tumor matched adjacent normal tissues spanning 19 NSCLC patients, drew a systematic transcriptome atlas. Joint analyses cellular compositions, differentially expressed genes (DEGs), cell–cell interactions, pseudotime trajectory, transcriptomic factors prognostic based The Cancer Genome Atlas (TCGA), revealed central roles cytotoxic effector T NK functional macrophages (Mφ) microenvironment heterogeneity LUAD LUSC. dominant subtype Mφ was FABP4- SPP1- Importantly, identified novel lymphocyte-related cluster, which named SELENOP- Mφ, further established its antitumor role both types, especially LUAD. Our comprehensive depiction definition clusters could help design personalized treatment patients practice.

Language: Английский

Citations

109
The RING finger protein family in health and disease DOI Creative Commons
Chunmei Cai, Yan‐Dong Tang, Jingbo Zhai

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Aug. 30, 2022

Ubiquitination is a highly conserved and fundamental posttranslational modification (PTM) in all eukaryotes regulating thousands of proteins. The RING (really interesting new gene) finger (RNF) protein, containing the domain, exerts E3 ubiquitin ligase that mediates covalent attachment (Ub) to target Multiple reviews have summarized critical roles tripartite-motif (TRIM) protein family, subgroup RNF proteins, various diseases, including cancer, inflammatory, infectious, neuropsychiatric disorders. Except for TRIMs, since numerous studies over past decades delineated other proteins also exert widespread involvement several their importance should not be underestimated. This review summarizes potential contribution dysregulated except pathogenesis some autoimmune neurodegenerative disorder. Since viral infection broadly involved induction development those this manuscript highlights regulatory excluding antiviral immune responses. In addition, we further discuss intervention strategies targeting prevention therapeutics human diseases.

Language: Английский

Citations

100
Machine Learning for Lung Cancer Diagnosis, Treatment, and Prognosis DOI Creative Commons
Yawei Li, Wu Xin, Ping Yang

et al.

Genomics Proteomics & Bioinformatics, Journal Year: 2022, Volume and Issue: 20(5), P. 850 - 866

Published: Oct. 1, 2022

The recent development of imaging and sequencing technologies enables systematic advances in the clinical study lung cancer. Meanwhile, human mind is limited effectively handling fully utilizing accumulation such enormous amounts data. Machine learning-based approaches play a critical role integrating analyzing these large complex datasets, which have extensively characterized cancer through use different perspectives from accrued In this article, we provide an overview machine that strengthen varying aspects diagnosis therapy, including early detection, auxiliary diagnosis, prognosis prediction, immunotherapy practice. Moreover, highlight challenges opportunities for future applications learning

Language: Английский

Citations

99
ALK-positive lung cancer: a moving target DOI
Jaime L. Schneider, W. Marston Linehan, Alice T. Shaw

et al.

Nature Cancer, Journal Year: 2023, Volume and Issue: 4(3), P. 330 - 343

Published: Feb. 16, 2023

Language: Английский

Citations

93