Light‐Triggered In Situ Gelation to Enable Robust Photodynamic‐Immunotherapy by Repeated Stimulations

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(24)

Published: April 22, 2019

Photodynamic therapy (PDT) has shown the potential of triggering systemic antitumor immune responses. However, while oxygen-deficient hypoxic tumor microenvironment is a factor that limits PDT efficacy, responses after conventional usually are not strong enough to eliminate metastatic tumors. Herein, light-triggered in situ gelation system containing photosensitizer-modified catalase together with poly(ethylene glycol) double acrylate (PEGDA) as polymeric matrix designed. Immune adjuvant nanoparticles further introduced into this trigger robust PDT. Following local injection mixed precursor solution tumors and subsequent light exposure, polymerization PEGDA can be initiated induce gelation. Such hybrid hydrogel long-term retention various agents ability enable persistent hypoxia relief multiple rounds PDT, which results significantly enhanced by multiround stimulation. Further combination such gel-based anticytotoxic T-lymphocyte antigen-4 checkpoint blockade offers only abscopal effect inhibit growth distant but also effective memory protection from rechallenged Therefore, single-dose greatly photoimmunotherapy means repeated stimulations.

Language: Английский

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X-ray-activated nanosystems for theranostic applications

Chemical Society Reviews, Journal Year: 2019, Volume and Issue: 48(11), P. 3073 - 3101

Published: Jan. 1, 2019

X-rays are widely applied in clinical medical facilities for radiotherapy (RT) and biomedical imaging. However, the sole use of cancer treatment leads to insufficient radiation energy deposition due low X-ray attenuation coefficients living tissues organs, producing unavoidable excessive doses with serious side effects healthy body parts. Over past decade, developments materials science nanotechnology have led rapid progress field X-ray-activated tumor-targeting nanosystems, which able tackle even systemic tumors relieve burden exposure large doses. Additionally, novel imaging contrast agents techniques also been developed. In comparison conventional external light sources (e.g., near infrared), technique is ideal activation nanosystems applications its nearly unlimited penetration depth organisms. this review, we systematically describe interaction mechanisms between provide an overview X-ray-sensitive recent on cancer-associated theranostic applications.

Language: Английский

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Immunological impact of cell death signaling driven by radiation on the tumor microenvironment

Nature Immunology, Journal Year: 2019, Volume and Issue: 21(2), P. 120 - 134

Published: Dec. 23, 2019

Language: Английский

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Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy

Nature Immunology, Journal Year: 2020, Volume and Issue: 21(10), P. 1160 - 1171

Published: Aug. 3, 2020

Language: Английский

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Time to abandon single-site irradiation for inducing abscopal effects

Nature Reviews Clinical Oncology, Journal Year: 2018, Volume and Issue: 16(2), P. 123 - 135

Published: Nov. 6, 2018

Language: Английский

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