Clinical Cancer Research,
Journal Year:
2012,
Volume and Issue:
18(20), P. 5546 - 5553
Published: Oct. 14, 2012
The
processes
of
cellular
growth
regulation
and
metabolism
are
closely
interrelated.
c-Myc
oncogene
is
a
"master
regulator"
which
controls
many
aspects
both
these
processes.
metabolic
changes
occur
in
transformed
cells,
driven
by
overexpression,
necessary
to
support
the
increased
need
for
nucleic
acids,
proteins,
lipids
rapid
proliferation.
At
same
time,
overexpression
results
coordinated
level
expression
gene
families
result
This
interesting
duality
effects
places
it
mainstream
transformational
gives
very
important
role
regulating
"transformed
phenotype."
induced
can
either
as
"primary
oncogene"
activated
amplification
or
translocation
downstream
effect
other
oncogenes.
In
case,
appears
that
plays
central
sustaining
with
transformation.
Although
efforts
use
therapeutic
target
have
been
quite
frustrating,
this
may
change
next
few
years.
Annual Review of Immunology,
Journal Year:
2013,
Volume and Issue:
31(1), P. 259 - 283
Published: Jan. 9, 2013
T
cell
activation
leads
to
dramatic
shifts
in
metabolism
protect
against
pathogens
and
orchestrate
the
action
of
other
immune
cells.
Quiescent
cells
require
predominantly
ATP-generating
processes,
whereas
proliferating
effector
high
metabolic
flux
through
growth-promoting
pathways.
Further,
functionally
distinct
subsets
energetic
biosynthetic
pathways
support
their
specific
functional
needs.
Pathways
that
control
function
are
intimately
linked,
changes
at
both
system
levels
have
been
shown
enhance
or
suppress
functions.
As
a
result
these
findings,
is
now
appreciated
as
key
regulator
specification
fate.
This
review
discusses
role
cellular
development,
activation,
differentiation,
highlight
clinical
relevance
opportunities
for
therapeutic
interventions
may
be
used
disrupt
pathogenesis.
