Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Cell, Journal Year: 2017, Volume and Issue: 169(6), P. 985 - 999

Published: June 1, 2017

Language: Английский

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Cancer stem cells revisited

Nature Medicine, Journal Year: 2017, Volume and Issue: 23(10), P. 1124 - 1134

Published: Oct. 1, 2017

Language: Английский

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Wnt signaling in cancer

Oncogene, Journal Year: 2016, Volume and Issue: 36(11), P. 1461 - 1473

Published: Sept. 12, 2016

Wnt signaling is one of the key cascades regulating development and stemness, has also been tightly associated with cancer. The role in carcinogenesis most prominently described for colorectal cancer, but aberrant observed many more cancer entities. Here, we review current insights into novel components pathways describe their impact on development. Furthermore, highlight expanding functions both solid liquid tumors. We findings how affects maintenance stem cells, metastasis immune control. Finally, provide an overview strategies to antagonize challenges that are such approaches.

Language: Английский

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Hepatocellular carcinoma

Nature Reviews Disease Primers, Journal Year: 2016, Volume and Issue: 2(1)

Published: April 14, 2016

Language: Английский

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Targeting cancer stem cell pathways for cancer therapy

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: Feb. 7, 2020

Abstract Since cancer stem cells (CSCs) were first identified in leukemia 1994, they have been considered promising therapeutic targets for therapy. These self-renewal capacity and differentiation potential contribute to multiple tumor malignancies, such as recurrence, metastasis, heterogeneity, multidrug resistance, radiation resistance. The biological activities of CSCs are regulated by several pluripotent transcription factors, OCT4, Sox2, Nanog, KLF4, MYC. In addition, many intracellular signaling pathways, Wnt, NF-κB (nuclear factor-κB), Notch, Hedgehog, JAK-STAT (Janus kinase/signal transducers activators transcription), PI3K/AKT/mTOR (phosphoinositide 3-kinase/AKT/mammalian target rapamycin), TGF (transforming growth factor)/SMAD, PPAR (peroxisome proliferator-activated receptor), well extracellular vascular niches, hypoxia, tumor-associated macrophages, cancer-associated fibroblasts, mesenchymal cells, matrix, exosomes, shown be very important regulators CSCs. Molecules, vaccines, antibodies, CAR-T (chimeric antigen receptor T cell) developed specifically CSCs, some these factors already undergoing clinical trials. This review summarizes the characterization identification depicts major pathways that regulate CSC development, discusses targeted therapy

Language: Английский

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Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Jan. 3, 2022

Abstract The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. deregulation signalling often leads to various serious diseases, including cancer non-cancer diseases. Although many articles have reviewed from aspects, systematic review encompassing the origin, composition, function, clinical trials tumour diseases is lacking. In this article, we comprehensively above five aspects combination with latest research. Finally, propose challenges opportunities for small-molecular compounds targeting Wnt disease treatment.

Language: Английский

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Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update

Nature Reviews Clinical Oncology, Journal Year: 2015, Volume and Issue: 12(8), P. 445 - 464

Published: April 7, 2015

Language: Английский

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Targeting the Wnt/β-catenin signaling pathway in cancer

Journal of Hematology & Oncology, Journal Year: 2020, Volume and Issue: 13(1)

Published: Dec. 1, 2020

The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, proliferation and differentiation, thus exerting crucial roles in tumorigenesis therapy response. Accumulated investigations highlight the therapeutic potential of agents targeting cancer. Wnt ligand/ receptor interface, β-catenin destruction complex TCF/β-catenin transcription are key components cascade have been targeted with interventions preclinical clinical evaluations. This scoping review aims at outlining latest progress on current approaches perspectives various types. Better understanding updates inhibitors, antagonists activators rationalizes innovative strategies for personalized treatment. Further warranted to confirm precise secure achieve optimal use benefits malignant diseases.

Language: Английский

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The Mediator complex: a central integrator of transcription

Nature Reviews Molecular Cell Biology, Journal Year: 2015, Volume and Issue: 16(3), P. 155 - 166

Published: Feb. 18, 2015

Language: Английский

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Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment

Stem Cells International, Journal Year: 2018, Volume and Issue: 2018, P. 1 - 16

Published: Jan. 1, 2018

Cancer stem cells (CSCs), also known as tumor-initiating (TICs), are suggested to be responsible for drug resistance and cancer relapse due in part their ability self-renew themselves differentiate into heterogeneous lineages of cells. Thus, it is important understand the characteristics mechanisms by which CSCs display therapeutic agents. In this review, we highlight key features that regulate CSC function well recent breakthroughs approaches targeting CSCs. This promises new insights provides better rationales accompany novel anticancer therapeutics.

Language: Английский

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