Transcriptional Regulation by Nrf2

Antioxidants and Redox Signaling, Journal Year: 2017, Volume and Issue: 29(17), P. 1727 - 1745

Published: Oct. 20, 2017

Nuclear factor E2-related 2 (Nrf2) is a transcription that coordinates the basal and stress-inducible activation of vast array cytoprotective genes. Understanding regulation Nrf2 activity downstream pathways has major implications for human health. Recent Advances: regulates components glutathione thioredoxin antioxidant systems, as well enzymes involved in phase I II detoxification exogenous endogenous products, NADPH regeneration, heme metabolism. It therefore represents crucial regulator cellular defense mechanisms against xenobiotic oxidative stress. In addition to responses, other processes, such autophagy, intermediary metabolism, stem cell quiescence, unfolded protein response. Given wide range processes controls, its tightly regulated at multiple levels. Here, we review different modes current knowledge Nrf2-mediated transcriptional control.It now clear lies center complex regulatory network. A full comprehension program will require an integrated consideration all factors determining activity.Additional computational experimental studies are needed obtain more dynamic global view gene regulation. particular, comparing how Nrf2-dependent network changes from physiological pathological condition can provide insight into disease instruct new treatment strategies.

Language: Английский

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Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

Cell, Journal Year: 2018, Volume and Issue: 175(7), P. 1842 - 1855.e16

Published: Nov. 15, 2018

Language: Английский

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Mediator and RNA polymerase II clusters associate in transcription-dependent condensates

Science, Journal Year: 2018, Volume and Issue: 361(6400), P. 412 - 415

Published: June 21, 2018

Models of gene control have emerged from genetic and biochemical studies, with limited consideration the spatial organization dynamics key components in living cells. We used live-cell superresolution light-sheet imaging to study Mediator coactivator RNA polymerase II (Pol II) directly. Pol each form small transient large stable clusters embryonic stem are colocalized clusters, which associate chromatin, properties phase-separated condensates, sensitive transcriptional inhibitors. suggest that Mediator, recruited by transcription factors at or clustered enhancer elements, interact condensates vivo.

Language: Английский

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Organization and function of the 3D genome

Nature Reviews Genetics, Journal Year: 2016, Volume and Issue: 17(11), P. 661 - 678

Published: Oct. 14, 2016

Language: Английский

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Transcriptional Addiction in Cancer

Cell, Journal Year: 2017, Volume and Issue: 168(4), P. 629 - 643

Published: Feb. 1, 2017

Language: Английский

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YY1 Is a Structural Regulator of Enhancer-Promoter Loops

Cell, Journal Year: 2017, Volume and Issue: 171(7), P. 1573 - 1588.e28

Published: Dec. 1, 2017

Language: Английский

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The multidimensional mechanisms of long noncoding RNA function

Genome biology, Journal Year: 2017, Volume and Issue: 18(1)

Published: Oct. 30, 2017

A major shift in our understanding of genome regulation has emerged recently. It is now apparent that the majority cellular transcripts do not code for proteins, and many them are long noncoding RNAs (lncRNAs). Increasingly, studies suggest lncRNAs regulate gene expression through diverse mechanisms. We review emerging mechanistic views cell nucleus. discuss functional interactions establish with other molecules as well relationship between lncRNA transcription function. While some these mechanisms specific to lncRNAs, others might be shared types genes.

Language: Английский

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Getting up to speed with transcription elongation by RNA polymerase II

Nature Reviews Molecular Cell Biology, Journal Year: 2015, Volume and Issue: 16(3), P. 167 - 177

Published: Feb. 18, 2015

Language: Английский

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Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

Nature, Journal Year: 2019, Volume and Issue: 572(7770), P. 543 - 548

Published: Aug. 1, 2019

Language: Английский

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BRD4 and Cancer: going beyond transcriptional regulation

Molecular Cancer, Journal Year: 2018, Volume and Issue: 17(1)

Published: Nov. 22, 2018

BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role super-enhancers (SEs) organization oncogenes expression regulation. Inhibition BRD4 shortcuts communication between SEs target promoters with a subsequent cell-specific repression to which cells are addicted cell death. To date, this most credited mechanism action BET inhibitors, class small molecules targeting proteins currently clinical trials several settings. However, recent evidence indicates that relevance goes beyond transcription regulation identifies as keeper genome stability. Indeed, non-transcriptional controlling DNA damage checkpoint activation repair well telomere maintenance has been proposed, throwing new lights into multiple functions opening perspectives on use BETi cancer. Here we discuss current available information non-canonical, their implications biology. Integrating already known gene regulation, propose "common" model explain genomic function. Furthermore, light transversal function provide interpretation cytotoxic activity possibilities wide focused employment these drugs

Language: Английский

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