Icaritin Exacerbates Mitophagy and Synergizes with Doxorubicin to Induce Immunogenic Cell Death in Hepatocellular Carcinoma DOI
Zhuo Yu, Jianfeng Guo, Mengying Hu

et al.

ACS Nano, Journal Year: 2020, Volume and Issue: 14(4), P. 4816 - 4828

Published: March 18, 2020

Hepatocellular carcinoma (HCC) resistant to both chemotherapy and immunotherapy is among the deadliest malignancies. Doxorubicin widely used in transarterial HCC can induce immunogenic cell death (ICD), but resulting immunogenicity still weak. We aim seek a strategy for improving efficacy of ICD based on an immunoregulatory drug called icaritin. Icaritin induced mitophagy apoptosis provoke mouse Hepa1-6 human Huh7 cells. A combination icaritin doxorubicin with molar ratio 1:2 played synergistic role induction. The poly lactic-co-glycolic acid (PLGA)-polyethylene glycol (PEG)-aminoethyl anisamide (AEAA) nanoparticle (NP) targeted codelivery remodeled immunosuppressive tumor microenvironment triggered robust immune memory response, which efficiently improved anti-HCC effect at early stage model. In addition, combo PLGA-PEG-AEAA NP together lenvatinib significantly prolonged survival time mice advanced HCC. Collectively, our findings reveal mechanism provide effective immune-based therapeutic

Language: Английский

Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features DOI
Daniela Sia, Yang Jiao,

Iris Martinez-Quetglas

et al.

Gastroenterology, Journal Year: 2017, Volume and Issue: 153(3), P. 812 - 826

Published: June 16, 2017

Language: Английский

Citations

761
The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects DOI Creative Commons

Weiwei Tang,

Ziyi Chen, Wenling Zhang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: June 10, 2020

Sorafenib is a multikinase inhibitor capable of facilitating apoptosis, mitigating angiogenesis and suppressing tumor cell proliferation. In late-stage hepatocellular carcinoma (HCC), sorafenib currently an effective first-line therapy. Unfortunately, the development drug resistance to becoming increasingly common. This study aims identify factors contributing ways mitigate resistance. Recent studies have shown that epigenetics, transport processes, regulated death, microenvironment are involved in HCC subsequent progression. summarizes discoveries achieved recently terms principles outlines approaches suitable for improving therapeutic outcomes patients.

Language: Английский

Citations

759
Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma DOI
Josep M. Llovet, Thierry de Baère, Laura Kulik

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2021, Volume and Issue: 18(5), P. 293 - 313

Published: Jan. 28, 2021

Language: Английский

Citations

694
CircRNA: a novel type of biomarker for cancer DOI
Heda Zhang, Linhong Jiang, Dawei Sun

et al.

Breast Cancer, Journal Year: 2017, Volume and Issue: 25(1), P. 1 - 7

Published: July 18, 2017

Language: Английский

Citations

681
Targeting tumor-associated macrophages to synergize tumor immunotherapy DOI Creative Commons
Xiaonan Xiang, Jianguo Wang, Di Lu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: Feb. 23, 2021

Abstract The current treatment strategies in advanced malignancies remain limited. Notably, immunotherapies have raised hope for a successful control of these diseases, but their therapeutic responses are suboptimal and vary considerably among individuals. Tumor-associated macrophages (TAMs) major component the tumor microenvironment (TME) often correlated with poor prognosis therapy resistance, including immunotherapies. Thus, deeper understanding complex roles TAMs immunotherapy regulation could provide new insight into TME. Furthermore, targeting is an emerging field interest due to that will synergize In this review, we summarize recent studies investigating involvement immune checkpoint inhibition, vaccines adoptive cell transfer therapies, discuss potential as adjuvant

Language: Английский

Citations

605
Hepatocellular Carcinoma Is Associated With Gut Microbiota Profile and Inflammation in Nonalcoholic Fatty Liver Disease DOI
Francesca Romana Ponziani, Sherrie Bhoori, Chiara Castelli

et al.

Hepatology, Journal Year: 2018, Volume and Issue: 69(1), P. 107 - 120

Published: April 17, 2018

The gut-liver axis plays a pivotal role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), which is third leading cause hepatocellular carcinoma (HCC) worldwide. However, link between gut microbiota and hepatocarcinogenesis remains to be clarified. aim this study was explore what features are associated with HCC patients cirrhosis NAFLD. A consecutive series NAFLD-related (group 1, 21 patients), without 2, 20 healthy controls 3, patients) studied for profile, intestinal permeability, inflammatory status, circulating mononuclear cells. We finally constructed model depicting most relevant correlations among these features, possibly involved hepatocarcinogenesis. Patients showed increased levels fecal calprotectin, while permeability similar but HCC. Plasma interleukin 8 (IL8), IL13, chemokine (C-C motif) ligand (CCL) CCL4, CCL5 were higher group an activated status monocytes. whole abundance Enterobacteriaceae Streptococcus reduction Akkermansia. Bacteroides Ruminococcaceae group, Bifidobacterium reduced. Akkermansia inversely correlated calprotectin concentration, turn humoral cellular markers. behavior also observed Bacteroides. Conclusion: Our results suggest that NAFLD profile systemic inflammation significantly can concur process

Language: Английский

Citations

530
Supramolecular Adhesive Hydrogels for Tissue Engineering Applications DOI
Yüe Zhao, Shanliang Song, Xiangzhong Ren

et al.

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(6), P. 5604 - 5640

Published: Jan. 13, 2022

Tissue engineering is a promising and revolutionary strategy to treat patients who suffer the loss or failure of an organ tissue, with aim restore dysfunctional tissues enhance life expectancy. Supramolecular adhesive hydrogels are emerging as appealing materials for tissue applications owing their favorable attributes such tailorable structure, inherent flexibility, excellent biocompatibility, near-physiological environment, dynamic mechanical strength, particularly attractive self-adhesiveness. In this review, key design principles various supramolecular strategies construct comprehensively summarized. Thereafter, recent research progress regarding applications, including primarily dermal repair, muscle bone neural vascular oral corneal cardiac fetal membrane hepatic gastric systematically highlighted. Finally, scientific challenges remaining opportunities underlined show full picture hydrogels. This review expected offer comparative views critical insights inspire more advanced studies on pave way different fields even beyond applications.

Language: Английский

Citations

447
The immunological and metabolic landscape in primary and metastatic liver cancer DOI
Xin Li, Pierluigi Ramadori, Dominik Pfister

et al.

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(9), P. 541 - 557

Published: July 29, 2021

Language: Английский

Citations

398
Spatial heterogeneity in the mammalian liver DOI
Shani Ben‐Moshe, Shalev Itzkovitz

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2019, Volume and Issue: 16(7), P. 395 - 410

Published: April 1, 2019

Language: Английский

Citations

383
Viral hepatitis and liver cancer DOI Creative Commons

Marc Ringehan,

Jane A. McKeating, Ulrike Protzer

et al.

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2017, Volume and Issue: 372(1732), P. 20160274 - 20160274

Published: Sept. 11, 2017

Hepatitis B and C viruses are a global health problem causing acute chronic infections that can lead to liver cirrhosis hepatocellular carcinoma (HCC). These the leading cause for HCC worldwide associated with significant mortality, accounting more than 1.3 million deaths per year. Owing its high incidence resistance treatment, cancer is second of cancer-related death worldwide, representing approximately 90% all primary cases. The majority viral-associated cases develop in subjects cirrhosis; however, hepatitis virus infection promote development without prior end-stage disease. Thus, understanding role viral essential future design treatments therapies this cancer. In review, we summarize current knowledge on hepatocarcinogenesis highlight direct indirect risk factors.This article part themed issue 'Human oncogenic viruses'.

Language: Английский

Citations

371