The Role of Gut–Liver Axis in Gut Microbiome Dysbiosis Associated NAFLD and NAFLD-HCC DOI Creative Commons
Qian Song, Xiang Zhang

Biomedicines, Journal Year: 2022, Volume and Issue: 10(3), P. 524 - 524

Published: Feb. 23, 2022

Nonalcoholic fatty liver disease (NAFLD) is considered as one of the most prevalent chronic diseases worldwide due to rapidly rising prevalence obesity and metabolic syndrome. As a hepatic manifestation disease, NAFLD begins with fat accumulation progresses inflammation, termed non-alcoholic steatohepatitis (NASH), fibrosis/cirrhosis, finally leading NAFLD-related hepatocellular carcinoma (NAFLD-HCC). Accumulating evidence showed that gut microbiome plays vital role in initiation progression through gut–liver axis. The axis mutual communication between comprising portal circulation, bile duct, systematic circulation. dysbiosis contributes development by dysregulating axis, increased intestinal permeability unrestrained transfer microbial metabolites into liver. In this review, we systematically summarized up-to-date information metabolomic changes along stages steatosis, NASH, fibrosis, NAFLD-HCC. components functions its association were then discussed. addition, highlighted current knowledge microbiome-based treatment strategies targeting for preventing associated HCC.

Language: Английский

Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention DOI
Daniel Q. Huang, Hashem B. El–Serag, Rohit Loomba

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2020, Volume and Issue: 18(4), P. 223 - 238

Published: Dec. 21, 2020

Language: Английский

Citations

1344
Immunotherapies for hepatocellular carcinoma DOI
Josep M. Llovet, Florian Castet, Mathias Heikenwälder

et al.

Nature Reviews Clinical Oncology, Journal Year: 2021, Volume and Issue: 19(3), P. 151 - 172

Published: Nov. 11, 2021

Language: Английский

Citations

1170
Human gut microbiome: hopes, threats and promises DOI Creative Commons
Patrice D. Cani

Gut, Journal Year: 2018, Volume and Issue: 67(9), P. 1716 - 1725

Published: June 22, 2018

The microbiome has received increasing attention over the last 15 years. Although gut microbes have been explored for several decades, investigations of role microorganisms that reside in human attracted much beyond classical infectious diseases. For example, numerous studies reported changes microbiota during not only obesity, diabetes, and liver diseases but also cancer even neurodegenerative is viewed as a potential source novel therapeutics. Between 2013 2017, number publications focusing on was, remarkably, 12 900, which represents four-fifths total 40 years investigated this topic. This review discusses recent evidence impact metabolic disorders focus selected key mechanisms. aims to provide critical analysis current knowledge field, identify putative issues or problems discuss misinterpretations. abundance metagenomic data generated comparing diseased healthy subjects can lead erroneous claim bacterium causally linked with protection onset disease. In fact, environmental factors such dietary habits, drug treatments, intestinal motility stool frequency consistency are all influence composition should be considered. cases bacteria Prevotella copri Akkermansia muciniphila will discussed examples.

Language: Английский

Citations

1150
Inflammation and Liver Cancer: Molecular Mechanisms and Therapeutic Targets DOI
Yoon Mee Yang, Sohee Kim, Ekihiro Seki

et al.

Seminars in Liver Disease, Journal Year: 2019, Volume and Issue: 39(01), P. 026 - 042

Published: Jan. 17, 2019

Abstract Hepatocellular carcinoma (HCC) is associated with chronic inflammation and fibrosis arising from different etiologies, including hepatitis B C alcoholic nonalcoholic fatty liver diseases. The inflammatory cytokines tumor necrosis factor-α interleukin-6 their downstream targets nuclear factor kappa (NF-κB), c-Jun N-terminal kinase (JNK), signal transducer activator of transcription 3 drive inflammation-associated HCC. Further, while adaptive immunity promotes immune surveillance to eradicate early HCC, cells, such as CD8+ T Th17 can also stimulate HCC development. Thus, the role hepatic system in development a highly complex topic. This review highlights cytokine signals, NF-κB, JNK, innate immunity, stellate cells discusses whether these pathways could be therapeutic targets. authors will discuss cholangiocarcinoma metastasis because biliary tumor-associated stroma are essential for primary tumor-derived mediators promote formation “premetastasis niche” liver.

Language: Английский

Citations

341
Intestinal Barrier in Human Health and Disease DOI Open Access

Natalia Di Tommaso,

Antonio Gasbarrini, Francesca Romana Ponziani

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(23), P. 12836 - 12836

Published: Dec. 6, 2021

The intestinal mucosa provides a selective permeable barrier for nutrient absorption and protection from external factors. It consists of epithelial cells, immune cells their secretions. gut microbiota participates in regulating the integrity function homeostatic balance. Pathogens, xenobiotics food can disrupt barrier, promoting systemic inflammation tissue damage. Genetic factors predispose individuals to dysfunction, changes composition are central this process. progressive identification these has led development concept ‘leaky syndrome’ ‘gut dysbiosis’, which underlie relationship between impairment, metabolic diseases autoimmunity. Understanding mechanisms underlying process is an intriguing subject research diagnosis treatment various extraintestinal diseases.

Language: Английский

Citations

324
Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma DOI Creative Commons

Jason Behary,

Nadia Amorim, Xiaotao Jiang

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Jan. 8, 2021

Abstract The gut microbiota is reported to modulate the immune response in hepatocellular carcinoma (HCC). Here, we employ metagenomic and metabolomic studies characterise patients with non-alcoholic fatty liver disease (NAFLD) related cirrhosis, or without HCC, evaluate its effect on peripheral an ex vivo model. We find that dysbiosis characterises of NAFLD-cirrhosis, compositional functional shifts occurring HCC development. Gene function NAFLD-HCC supports short chain acid production, this confirmed by studies. Ex show bacterial extracts from microbiota, but not control groups, elicit a T cell immunosuppressive phenotype, characterised expansion regulatory cells attenuation CD8 + cells. Our study suggest distinctive microbiome/metabolomic profile, can response.

Language: Английский

Citations

313
Gut microbiome, liver immunology, and liver diseases DOI Open Access
Rui Wang, Ruqi Tang, Bo Li

et al.

Cellular and Molecular Immunology, Journal Year: 2020, Volume and Issue: 18(1), P. 4 - 17

Published: Dec. 14, 2020

Language: Английский

Citations

303
Global Epidemiology and Genetics of Hepatocellular Carcinoma DOI

Ming Ren Toh,

Evelyn Wong, Sunny H. Wong

et al.

Gastroenterology, Journal Year: 2023, Volume and Issue: 164(5), P. 766 - 782

Published: Feb. 2, 2023

Language: Английский

Citations

290
Gut microbiome in HCC – Mechanisms, diagnosis and therapy DOI Open Access
Robert F. Schwabe, Tim F. Greten

Journal of Hepatology, Journal Year: 2020, Volume and Issue: 72(2), P. 230 - 238

Published: Jan. 15, 2020

Language: Английский

Citations

275
A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease DOI Creative Commons
Cyrielle Caussy, Anupriya Tripathi,

Greg Humphrey

et al.

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: March 29, 2019

Abstract The presence of cirrhosis in nonalcoholic-fatty-liver-disease (NAFLD) is the most important predictor liver-related mortality. Limited data exist concerning diagnostic accuracy gut-microbiome-derived signatures for detecting NAFLD-cirrhosis. Here we report 16S gut-microbiome compositions 203 uniquely well-characterized participants from a prospective twin and family cohort, including 98 probands encompassing entire spectrum NAFLD 105 their first-degree relatives, assessed by advanced magnetic-resonance-imaging. We show strong familial correlation profiles, driven shared housing. panel 30 features, 27 bacterial features with discriminatory ability to detect NAFLD-cirrhosis using Random Forest classifier model. In derivation cohort probands, model has robust (AUROC 0.92) NAFLD-cirrhosis, confirmed validation relatives proband 0.87). This study provides evidence fecal-microbiome-derived signature

Language: Английский

Citations

273