Intraoperative ketamine for reduction in postpartum depressive symptoms after cesarean delivery: A double‐blind, randomized clinical trial DOI Creative Commons
Jiaxin Yao, Tingting Song, Yue Zhang

et al.

Brain and Behavior, Journal Year: 2020, Volume and Issue: 10(9)

Published: Aug. 18, 2020

Abstract Background Postpartum depression (PPD) is a common mental disease happens in perinatal period. Ketamine as an anesthesia and analgesia drug has been used for long time. In recent years, ketamine proved to have antidepression effect with single administration. We hypothesized that intraoperative can reduce postpartum depressive symptoms after cesarean delivery. Methods randomized, double‐blind, placebo‐controlled study trail, healthy women scheduled delivery were randomly assigned receive intravenous (0.25 mg/kg diluted 5 ml 0.9% saline) or placebo (5 of within min following clamping the neonatal umbilical cord. The primary outcome was degree symptoms, which evaluated by Edinburgh Postnatal Depression Scale (EPDS, threshold 9/10 used) at 1 week, 2 weeks, month secondary numerical rating scale (NRS) score pain days postpartum. This trail registered Chinese Clinical Trial Registry, number ChiCTR1900022464. Results Between 26 January 2019 15 July 2019, 502 subjects screened 330 allocated: 165 (50%) group group. There significant differences between week (13.1% vs. 22.6%, respectively; p = .029). However, no difference found two groups weeks (11.8% 16.8%, .209) (10.5% 14.2%, .319). NRS wound (3.0 ± 0.9 4.0 1.0, < .001) uterine contraction 4.1 0.9, lower compared prevalence headache, hallucination, dizziness higher than during operation. Conclusions Operative mg/kg) week. long‐time remained be seen.

Language: Английский

Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials DOI
Samantha Meltzer‐Brody,

Helen Colquhoun,

Robert Riesenberg

et al.

The Lancet, Journal Year: 2018, Volume and Issue: 392(10152), P. 1058 - 1070

Published: Aug. 31, 2018

Language: Английский

Citations

659
The lived experience of depression: a bottom‐up review co‐written by experts by experience and academics DOI Open Access
Paolo Fusar‐Poli, Andrés Estradé, Giovanni Stanghellini

et al.

World Psychiatry, Journal Year: 2023, Volume and Issue: 22(3), P. 352 - 365

Published: Sept. 15, 2023

We provide here the first bottom-up review of lived experience depression, co-written by experts and academics. First-person accounts within outside medical field were screened discussed in collaborative workshops involving numerous individuals with family members carers, representing a global network organizations. The material was enriched phenomenologically informed perspectives shared all collaborators cloud-based system. subjective world depression characterized an altered emotions body (feeling overwhelmed negative emotions, unable to positive stuck heavy aching drained energy, detached from mind, world); self (losing sense purpose existential hope, mismatch between past depressed self, feeling painfully incarcerated, losing control over one's thoughts, capacity act on world; numb, empty, non-existent, dead, dreaming death as possible escape route); time (experiencing alteration vital biorhythms, overwhelming past, stagnation present, impossibility future). social cultural context interpersonal experiences (struggling communication, loneliness estrangement, perceiving stigma stereotypes), varied across different cultures, ethnic or racial minorities, genders. perception recovery contrasting attitudes towards recovery, recognizing journey, vulnerability need for professional help), did receiving pharmacotherapy, psychotherapy, well physical health interventions. These findings can inform clinical practice, research education. This journey also help us understand nature our own feelings, what is believe something, be living human being.

Language: Английский

Citations

49
Effects of ketamine and esketamine on preventing postpartum depression after cesarean delivery: A meta-analysis DOI Creative Commons
Shuying Li, Wenqin Zhou, Ping Li

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 351, P. 720 - 728

Published: Jan. 28, 2024

Ketamine and esketamine has been suggested to have potential efficacy in preventing postpartum depression (PPD) recent years. The aim of this meta-analysis was evaluate the effectiveness ketamine on PPD after cesarean delivery.

Language: Английский

Citations

23
Development and validation of a machine learning algorithm for predicting the risk of postpartum depression among pregnant women DOI Creative Commons
Yiye Zhang,

Shuojia Wang,

Alison Hermann

et al.

Journal of Affective Disorders, Journal Year: 2020, Volume and Issue: 279, P. 1 - 8

Published: Sept. 30, 2020

There is a scarcity in tools to predict postpartum depression (PPD). We propose machine learning framework for PPD risk prediction using data extracted from electronic health records (EHRs).

Language: Английский

Citations

119
Fetal and Infant Outcomes in the Offspring of Parents With Perinatal Mental Disorders: Earliest Influences DOI Creative Commons
Evin Aktar, Jin Qu, Peter J. Lawrence

et al.

Frontiers in Psychiatry, Journal Year: 2019, Volume and Issue: 10

Published: June 27, 2019

Mental illness is highly prevalent and runs in families. disorders are considered to enhance the risk for development of psychopathology offspring. This heightened related separate joint effects inherited genetic vulnerabilities psychopathology, as well environmental influences. Early years life suggested be a key developmental phase intergenerational transmission. Available evidence supports idea that early exposure parental during pregnancy first post-partum year, may child psychological functioning beyond period, up adulthood years. not only highlights importance intervening break chain transmission but also raises question whether interventions targeting mental this period alleviate these prolonged adverse infant The current review focuses on specific conveyed from mentally ill parents offspring year. We present summary available associations perinatal with outcomes at behavioral biological, neuro-physiological levels. Next, we adress discuss mitigate psychopathology. summarized psychopathology-related changes parents' behavior physiology behavioral, correlates period. These alterations constitute later and/or adult forms thus Targeting or mother-infant interactions isolation postnatal sufficient improve outcomes, whereas both seem promising alleviating

Language: Английский

Citations

112
Transgenerational hypocortisolism and behavioral disruption are induced by the antidepressant fluoxetine in male zebrafishDanio rerio DOI Open Access
Marilyn N. Vera-Chang, Antony D. St‐Jacques,

Rémi Gagné

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2018, Volume and Issue: 115(52)

Published: Dec. 10, 2018

The global prevalence of depression is high during childbearing. Due to the associated risks mother and baby, selective serotonin reuptake inhibitor fluoxetine (FLX) often first line treatment. Given that FLX readily crosses placenta, a fetus may be susceptible disruptive effects this highly plastic stage development. Here, we demonstrate 6-day exposure fetus-relevant concentration at critical developmental suppresses cortisol levels in adult zebrafish (F 0 ). This effect persists for three consecutive generations unexposed descendants 1 F 3 ) without diminution more pronounced males. We also show vivo response interrenal (fish “adrenal”) an i.p. injection adrenocorticotropic hormone was reduced males from lineages. Transcriptomic profiling whole kidney containing cells revealed early significantly modified numerous pathways closely with synthesis male adults generations. low are linked exploratory behaviors 2 cause concern given prescription rates pregnant women potential long-term negative impacts on humans exposed these therapeutic drugs.

Language: Английский

Citations

90
Prophylactic use of ketamine reduces postpartum depression in Chinese women undergoing cesarean section✰ DOI
Jiahui Ma, Saiying Wang,

He‐Ya Yu

et al.

Psychiatry Research, Journal Year: 2019, Volume and Issue: 279, P. 252 - 258

Published: March 16, 2019

Language: Английский

Citations

86
Social Behavior as a Transdiagnostic Marker of Resilience DOI
Ruth Feldman

Annual Review of Clinical Psychology, Journal Year: 2021, Volume and Issue: 17(1), P. 153 - 180

Published: Jan. 12, 2021

The recent shift from psychopathology to resilience and diagnosis functioning requires the construction of transdiagnostic markers adaptation. This review describes a model that is based on neurobiology affiliation initial condition mammals mature in context mother's body social behavior. proposes three tenets resilience-plasticity, sociality, meaning-and argues coordinated behavior stands at core sustaining resilience. Two lines maturation are charted, across animal evolution throughout human development, culminating reciprocity empathy, mutuality, perspective-taking. Cumulative evidence ages clinical conditions our behavioral coding system demonstrates reciprocity, defined by plasticity individual, dyadic, group levels, denotes resilience, whereas two poles disengagement/avoidance intrusion/rigidity characterize specific psychopathologies, each with distinct signature. Attention developmentally sensitive dimension meaning sociality may open new, behavior-based pathways

Language: Английский

Citations

71
Postpartum Depression: Current Status and Possible Identification Using Biomarkers DOI Creative Commons
Yi Yu,

Hong-Feng Liang,

Jing Chen

et al.

Frontiers in Psychiatry, Journal Year: 2021, Volume and Issue: 12

Published: June 11, 2021

Postpartum depression (PPD) is a serious health issue that can affect about 15% of the female population within after giving birth. It often conveys significant negative consequences to offsprings. The symptoms and risk factors are somewhat similar those found in non-postpartum depression. main difference resides fact PPD triggered by postpartum specific factors, including especially biological changes hormone levels. Patients usually diagnosed using questionnaire onsite or clinic. Treatment involves psychotherapy antidepressant medications. In recent years, there have been more researches on identification markers for PPD. this review, we will focus current research status PPD, with an emphasis progress made biomarkers.

Language: Английский

Citations

68
Antipsychotic medication for women with schizophrenia spectrum disorders DOI Creative Commons
Bodyl A. Brand,

Yudith R. A. Haveman,

Franciska de Beer

et al.

Psychological Medicine, Journal Year: 2021, Volume and Issue: 52(4), P. 649 - 663

Published: Nov. 12, 2021

Abstract There are significant differences between men and women in the efficacy tolerability of antipsychotic drugs. Here, we provide a comprehensive overview what is currently known about pharmacokinetics pharmacodynamics antipsychotics with schizophrenia spectrum disorders (SSDs) translate these insights into considerations for clinical practice. Slower drug absorption, metabolism excretion all lead to higher plasma levels, which increase risk side-effects. Moreover, reach dopamine receptor occupancy compared at similar serum since oestrogens sensitivity. As current treatment guidelines based on studies predominantly conducted men, likely be overmedicated by default. The overmedicating generally increases when sex hormone levels high (e.g. during ovulation gestation), whereas doses may required low-hormonal phases menstruation menopause). For premenopausal women, exceptions quetiapine lurasidone, should lower largest adjustments olanzapine. Clinicians wary side-effects that particularly harmful such as hyperprolactinaemia can cause oestrogen deficiency metabolic symptoms cardiovascular diseases. Given protective effects course SSD, replacement therapy considered postmenopausal patients, who more vulnerable yet require dosages most efficacy. In conclusion, there need tailored, female-specific prescription guidelines, take account across different life.

Language: Английский

Citations

68