Environmental Pollution, Journal Year: 2020, Volume and Issue: 270, P. 116164 - 116164
Published: Nov. 27, 2020
Language: Английский
Biological reviews/Biological reviews of the Cambridge Philosophical Society, Journal Year: 2022, Volume and Issue: 97(4), P. 1346 - 1364
Published: March 1, 2022
Animal behaviour is remarkably sensitive to disruption by chemical pollution, with widespread implications for ecological and evolutionary processes in contaminated wildlife populations. However, conventional approaches applied study the impacts of pollutants on seldom address complexity natural environments which contamination occurs. The aim this review guide rapidly developing field behavioural ecotoxicology towards increased environmental realism, complexity, mechanistic understanding. We identify research areas ecology that date have been largely overlooked within but promise yield valuable insights, including within- among-individual variation, social networks collective behaviour, multi-stressor interactions. Further, we feature methodological technological innovations enable collection data pollutant-induced changes at an unprecedented resolution scale laboratory field. In era rapid change, there urgent need advance our understanding real-world pollution behaviour. This therefore provides a roadmap major outstanding questions highlights cross-talk other disciplines order find answers.
Language: Английский
Citations
98
Neuroscience & Biobehavioral Reviews, Journal Year: 2019, Volume and Issue: 108, P. 749 - 770
Published: Nov. 26, 2019
The componential view of human emotion recognises that affective states comprise conscious, behavioural, physiological, neural and cognitive elements. Although many animals display bodily behavioural changes consistent with the occurrence similar to those seen in humans, question whether which species these are accompanied by conscious experiences remains controversial. Finding scientifically valid methods for investigating markers subjective component affect both humans is central developing a comparative understanding processes mechanisms its evolution distribution across taxonomic groups, our animal welfare, development models disorders. Here, contemporary evidence indicating potential processing reviewed, extending this search include processing. We do combining animal-focused approaches investigations components non-conscious emotional neuropsychological research into structure functions emotions.
Language: Английский
Citations
129
Environmental Science & Technology, Journal Year: 2021, Volume and Issue: 55(24), P. 16299 - 16312
Published: Dec. 2, 2021
Antidepressants are one of the most commonly prescribed pharmaceutical classes for treatment psychiatric conditions. They act via modulation brain monoaminergic signaling systems (predominantly serotonergic, adrenergic, dopaminergic) that show a high degree structural conservation across diverse animal phyla. A reasonable assumption, therefore, is exposed fish and other aquatic wildlife may be affected by antidepressants released into natural environment. Indeed, there substantial data reported exposure effects in fish, albeit concentrations exceeding those occurring environments. From critical analysis available evidence risk quotients (RQs) were derived from laboratory-based studies selection detected We conclude likelihood on standard measured end points used assessment (i.e., excluding behavior) low levels Nevertheless, some behavior have been environmentally relevant exposures, can bioaccumulate tissues. Limitations datasets to calculate RQs revealed important gaps which future research should directed more accurately assess risks posed fish. Developing greater certainty surrounding requires attention toward behaviors relating individual fitness, employment realistic levels, chronic scenarios, mixtures analyses, especially given wide range similarly acting compounds
Language: Английский
Citations
65
Proceedings of the Royal Society B Biological Sciences, Journal Year: 2021, Volume and Issue: 288(1944), P. 20202294 - 20202294
Published: Feb. 10, 2021
Environmental contamination by pharmaceuticals is global, substantially altering crucial behaviours in animals and impacting on their reproduction survival. A key question whether the consequences of these pollutants extend beyond mean behavioural changes, restraining differences behaviour between individuals. In a controlled, two-year, multigenerational experiment with independent mesocosm populations, we exposed guppies ( Poecilia reticulata ) to environmentally realistic levels ubiquitous pollutant fluoxetine (Prozac). Fish (unexposed: n = 59, low fluoxetine: 57, high 58) were repeatedly assayed four separate occasions for activity risk-taking behaviour. Fluoxetine homogenized individuals' activity, individual variation populations even concentrations falling less than half that unexposed populations. To understand proximate mechanism underlying tested relative contribution within individuals overall decline variation. We found strong evidence erodes but not individuals, revealing hidden contaminant phenotypic fish—likely impair adaptive potential environmental change.
Language: Английский
Citations
60
Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 424, P. 127705 - 127705
Published: Nov. 7, 2021
Plastic pollution has become a major concern on global scale. The plastic is broken down into minuscule particles, which have an impact the biosystems, however long-term impacts through entire generation largely unknown. Here, we present first whole study exposing fish to 500 nm polystyrene particle at environmentally relevant concentrations. Short- and adverse effects were investigated in zebrafish model organism using holistic multi-omics approach. particles accumulated yolk sac of young larvae short-term biological included immune-relevant gene regulation related inflammation tolerance as well disruption metabolic processes, such fatty acid lipid pathways. comprised regulations pointing towards skin and/or gill inflammation, dysbiosis gut microbiota, tendency decreased condition factor adult males lowered reproductive capability. From this study, it can be concluded that exposures nanoparticles population ecosystem level likely also other vertebrates.
Language: Английский
Citations
60
Environmental Research, Journal Year: 2021, Volume and Issue: 205, P. 112495 - 112495
Published: Dec. 6, 2021
Pharmaceutical drugs have become consumer products, with a daily use for some of them. The volume production and consumption is such that they environmental pollutants. Their transfer to wastewater through urine, feces or rinsing in case skin use, associated partial elimination by treatment plants generalize pollution the hydrosphere, including drinking water, sediments, soils, food chain plants. Here, we review potential effects exposure three classes pharmaceutical drugs, i.e. antibiotics, antidepressants non-steroidal anti-inflammatory on neurodevelopment. Experimental studies analyzing their underlying modes action those related endocrine disruption, molecular mechanisms epigenetic modifications are presented. In addition, contribution brain imaging assessment adverse these pharmaceuticals approached.
Language: Английский
Citations
60
Water Research, Journal Year: 2022, Volume and Issue: 222, P. 118878 - 118878
Published: July 18, 2022
This study aimed to provide insights into the risk posed by psychopharmaceuticals and illicit drugs in European surface waters, identify current knowledge gaps hampering this assessment. First, availability quality of data on concentrations waters (occurrence) toxicity aquatic organisms (hazard) were reviewed. If both occurrence ecotoxicity available, quotients (risk) calculated. Where abundant a species sensitivity distribution (SSD) was constructed, from which hazardous concentration for 5% (HC5) derived, allowing derive integrated multi-species risks. A total 702 compounds categorised as based combination all 502 anatomical therapeutic class (ATC) 'N' pharmaceuticals list according Dutch Opium Act. Of these, 343 (49%) returned data, while only 105 (15%) data. Moreover, many tests used irrelevant endpoints neurologically active compounds, such mortality, may underestimate hazard psychopharmaceuticals. Due limitations, risks could be assessed 87 (12%) with 23 (3.3%) indicating potential risk, several highly prescribed neither nor Primary bottlenecks calculation included lack diversity test ecotoxicological end points, large disparities between well studied understudied identified merit concern, that any driving research priorities. Despite gaps, we concluded presence substantial part (26%) data-rich present an ecological non-target organisms.
Language: Английский
Citations
40
Environmental Pollution, Journal Year: 2023, Volume and Issue: 341, P. 122889 - 122889
Published: Nov. 15, 2023
Language: Английский
Citations
37
Depression and Anxiety, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 48
Published: June 20, 2023
As an important part in international disease, mental disorders seriously damage human health and social stability, which show the complex pathogenesis increasing incidence year by year. In order to analyze of as soon possible look for targeted drug treatment psychiatric diseases, a more reasonable animal model is imperious demands. Benefiting from its high homology with genome, brain tissue highly similar that humans, it easy realize whole-body optical visualization high-throughput screening; zebrafish stands out among many models disorders. Here, valuable qualified could be established through behavioral test sociological analysis, are simulated combined molecular analyses other detection methods. This review focuses on advances simulate disorders; summarizes various characterization means, use equipment, operation principle; sums up disorder modeling methods; puts forward current challenges future development trend, contribute theoretical supports exploration mechanisms strategies
Language: Английский
Citations
26
Stress, Journal Year: 2020, Volume and Issue: 24(1), P. 1 - 18
Published: Feb. 10, 2020
Stress is a common cause of neuropsychiatric disorders, evoking multiple behavioral, endocrine and neuro-immune deficits. Animal models have been extensively used to understand the mechanisms stress-related disorders develop novel strategies for their treatment. Complementing rodent clinical studies, zebrafish (Danio rerio) one most important model organisms in biomedicine. Rapidly becoming popular species stress neuroscience research, are highly sensitive both acute chronic stress, show robust, well-defined behavioral physiological responses. Here, we critically evaluate utility zebrafish-based studying CNS pathogenesis, assess advantages limitations these aquatic models, emphasize relevance development anti-stress therapies. Overall, emerges as powerful organism research. Although fish generally display evolutionarily conserved responses zebrafish-specific aspects neurogenesis, neuroprotection may be particularly interesting explore further, they offer additional insights into pathogenesis that complement (rather than merely replicate) findings. Compared mammals, also characterized by increased availability gene-editing tools higher throughput drug screening, thus being able uniquely empower translational research genetic determinants resilience, well foster innovative discovery
Language: Английский
Citations
68