World Journal of Diabetes,
Journal Year:
2023,
Volume and Issue:
14(4), P. 396 - 411
Published: April 11, 2023
The
global
prevalence
of
obesity
is
increasing
rapidly
with
an
exponential
rise
in
incidence
type
2
diabetes
mellitus
recent
years.
'Diabesity',
the
term
coined
to
show
strong
interlink
between
and
diabetes,
direct
cons-equence
pandemic,
poses
significant
challenges
management
disease.
Without
addressing
clinical
mechanistic
complications
such
as
metabolic-associated
fatty
liver
disease
obstructive
sleep
apnoea,
a
rational
algorithm
for
diabesity
cannot
be
developed.
Several
classes
anti-diabetic
medications
including
insulins,
sulphonylureas,
thiazolidinediones
meglitinides
are
associated
risk
weight
gain
may
potentially
worsen
diabesity.
Therefore,
appropriate
selection
antidiabetic
drug
regimen
crucial
medical
role
non-pharmacological
measures
dietary
adjustments,
exercise
interventions
bariatric
procedures
should
also
emphasised.
Unfortunately,
importance
optimal
often
overlooked
by
professionals
when
achieving
adequate
glycemic
control
which
results
inappropriate
its
complications.
This
review
provides
narrative
update
on
evidence
behind
Journal of Clinical and Translational Hepatology,
Journal Year:
2019,
Volume and Issue:
X(X), P. 1 - 11
Published: Dec. 28, 2019
Nonalcoholic
fatty
liver
disease
(NAFLD)
is
a
systemic
disorder
with
complex
multifactorial
pathogenesis
and
heterogenous
clinical
manifestations.
NAFLD,
once
believed
to
be
an
innocuous
condition,
has
now
become
the
most
common
cause
of
chronic
in
many
countries
worldwide.
NAFLD
already
highly
prevalent
general
population,
owing
rising
incidence
obesity
diabetes
mellitus,
its
impact
on
global
healthcare
are
expected
increase
future.
A
subset
patients
develops
progressive
leading
cirrhosis,
hepatocellular
carcinoma,
failure.
emerged
as
one
causes
cirrhosis
carcinoma
recent
years.
Moreover,
HCC
can
occur
even
absence
cirrhosis.
Compared
increases
risk
liver-related,
cardiovascular
all-cause
mortality.
bidirectionally
associated
metabolic
syndrome.
contributes
aggravation
pathophysiology
atherosclerosis,
diseases,
kidney
disease.
In
addition,
linked
colorectal
polyps,
polycystic
ovarian
syndrome,
osteoporosis,
obstructive
sleep
apnea,
stroke,
various
extrahepatic
malignancies.
Extended
resection
steatotic
increased
failure
There
increasing
trend
NAFLD-related
requiring
transplantation,
recurrence
such
almost
universal.
This
review
discusses
growing
burden
outcomes,
adverse
associations
diseases.
Journal of Clinical and Translational Hepatology,
Journal Year:
2021,
Volume and Issue:
10(2), P. 329 - 338
Published: Oct. 19, 2021
Nonalcoholic
fatty
liver
disease
(NAFLD)
is
a
multisystemic
clinical
condition
that
presents
with
wide
spectrum
of
extrahepatic
manifestations,
such
as
obesity,
type
2
diabetes
mellitus,
metabolic
syndrome,
cardiovascular
diseases,
chronic
kidney
disease,
malignancies,
cognitive
disorders,
and
polycystic
ovarian
syndrome.
Among
NAFLD
patients,
the
most
common
mortality
etiology
followed
by
liver-related
complications.
Furthermore,
severity
diseases
parallel
to
NAFLD.
In
practice,
awareness
associations
concomitant
major
importance
for
initiating
prompt
timely
screening
multidisciplinary
management
spectrum.
2020,
consensus
from
22
countries
redefined
(dysfunction)-associated
(MAFLD),
which
resulted
in
redefinition
corresponding
population.
Although
patients
diagnosed
MAFLD
mostly
overlap,
populations
are
not
identical.
this
review,
we
compared
key
between
MAFLD.
World Journal of Diabetes,
Journal Year:
2023,
Volume and Issue:
14(4), P. 396 - 411
Published: April 11, 2023
The
global
prevalence
of
obesity
is
increasing
rapidly
with
an
exponential
rise
in
incidence
type
2
diabetes
mellitus
recent
years.
'Diabesity',
the
term
coined
to
show
strong
interlink
between
and
diabetes,
direct
cons-equence
pandemic,
poses
significant
challenges
management
disease.
Without
addressing
clinical
mechanistic
complications
such
as
metabolic-associated
fatty
liver
disease
obstructive
sleep
apnoea,
a
rational
algorithm
for
diabesity
cannot
be
developed.
Several
classes
anti-diabetic
medications
including
insulins,
sulphonylureas,
thiazolidinediones
meglitinides
are
associated
risk
weight
gain
may
potentially
worsen
diabesity.
Therefore,
appropriate
selection
antidiabetic
drug
regimen
crucial
medical
role
non-pharmacological
measures
dietary
adjustments,
exercise
interventions
bariatric
procedures
should
also
emphasised.
Unfortunately,
importance
optimal
often
overlooked
by
professionals
when
achieving
adequate
glycemic
control
which
results
inappropriate
its
complications.
This
review
provides
narrative
update
on
evidence
behind
