Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156602 - 156602
Published: March 2, 2025
Language: Английский
Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 45(8), P. 6651 - 6666
Published: Aug. 12, 2023
Oxidative stress is a critical factor in the pathogenesis and progression of diabetes its associated complications. The imbalance between reactive oxygen species (ROS) production body’s antioxidant defence mechanisms leads to cellular damage dysfunction. In diabetes, chronic hyperglycaemia mitochondrial dysfunction contribute increased ROS production, further exacerbating oxidative stress. This burden adversely affects various aspects including impaired beta-cell function insulin resistance, leading disrupted glucose regulation. Additionally, stress-induced blood vessels endothelial development diabetic vascular complications such as retinopathy, nephropathy, cardiovascular diseases. Moreover, organs tissues throughout body, kidneys, nerves, eyes, are vulnerable stress, resulting neuropathy, retinopathy. Strategies mitigate include therapy, lifestyle modifications, effective management hyperglycaemia. However, research necessary comprehensively understand underlying evaluate efficacy interventions preventing treating By addressing it might be possible alleviate improve patient outcomes.
Language: Английский
Citations
204
Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14
Published: Feb. 7, 2023
Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycaemia, with absolute insulin deficiency or resistance as the main cause, and causes damage to various target organs including heart, kidney neurovascular. In terms of pathological physiological mechanisms DM, oxidative stress one leading DM an important link between its complications. Oxidative phenomenon resulting from imbalance production free radicals scavenging antioxidant systems. The site reactive oxygen species (ROS) mitochondria, which are also organelles damaged. high glucose environment, impaired electron transport chain within mitochondria leads ROS, prompts increased proton leakage altered mitochondrial membrane potential (MMP), in turn releases cytochrome c (cyt-c), apoptosis. This subsequently vicious cycle clearance body's system, transcription protein synthesis DNA (mtDNA), responsible for encoding proteins, repair systems, contributing dysfunction. paper reviews dysfunction environment induced model, looks forward providing new treatment plan based on
Language: Английский
Citations
81
Renal Failure, Journal Year: 2023, Volume and Issue: 45(1)
Published: Feb. 10, 2023
Diabetic kidney disease (DKD) is a common complication of diabetes and has become the leading cause end-stage disease. The pathogenesis DKD complicated, oxidative stress considered as core onset. High glucose can lead to increased production reactive oxygen species (ROS) via polyol, PKC, AGE/RAGE hexosamine pathways, resulting in enhanced response. In this way, pathways such PI3K/Akt, TGF-β1/p38-MAPK NF-κB are activated, inducing endothelial cell apoptosis, inflammation, autophagy fibrosis that histologic functional abnormalities finally result injury. Presently, treatment for remains an unresolved issue. Traditional Chinese medicine (TCM) unique advantages prevention attributed its multi-target, multi-component, multi-pathway characteristics. Numerous studies have proved herbs (e.g., Golden Thread, Kudzuvine Root, Tripterygium glycosides, Ginseng) patent medicines Shenshuaining Tablet, Compound Rhizoma Coptidis Capsule, Zishen Tongluo Granule) effective treatment. present review described role effect TCM intervention treatment, attempt provide evidence clinical practice.
Language: Английский
Citations
73
Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 274, P. 111282 - 111282
Published: Feb. 5, 2024
Language: Английский
Citations
17
World Journal of Diabetes, Journal Year: 2023, Volume and Issue: 14(2), P. 62 - 75
Published: Feb. 14, 2023
Diabetes mellitus (DM) is one of the most common metabolic disorders characterized by elevated blood glucose levels. Prolonged uncontrolled hyperglycemia often leads to multi-organ damage including diabetic neuropathy, nephropathy, retinopathy, cardiovascular disorders, and foot ulcers. Excess production free radicals causing oxidative stress in tissues considered be primary cause onset progression DM associated complications. Natural polyphenols can used induce or inhibit expression antioxidant enzymes such as glutathione peroxidase, heme oxygenase-1, superoxide dismutase, catalase that are essential maintaining redox balance, ameliorate stress. Caffeic acid (CA) a polyphenolderived from hydroxycinnamic possesses numerous physiological properties includ-ing antioxidant, anti-inflammatory, anti-atherosclerotic, immune-stimulatory, cardioprotective, antiproliferative, hepatoprotective activities. CA acts regulatory compound affecting biochemical pathways multiple targets. These include various transcription factors nuclear factor-B, tumor necrosis factor-α, interleukin-6, cyclooxygenase-2, factor erythroid 2-related 2. Therefore, this review summarizes pharmacological properties, molecular mechanisms, pharmacokinetic profile mitigating adverse effects The bioavailability, drug delivery, clinical trials have also been discussed.
Language: Английский
Citations
33
Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)
Published: Feb. 9, 2023
Diabetic ulcers (DUs) are one of the most serious complications diabetes mellitus. The application a functional dressing is crucial step in DU treatment and associated with patient's recovery prognosis. However, traditional dressings simple structure single function cannot meet clinical requirements. Therefore, researchers have turned their attention to advanced polymer hydrogels solve therapeutic bottleneck treatment. Hydrogels class gels three-dimensional network that good moisturizing properties permeability promote autolytic debridement material exchange. Moreover, mimic natural environment extracellular matrix, providing suitable surroundings for cell proliferation. Thus, different mechanical strengths biological been extensively explored as platforms. In this review, we define types elaborate mechanisms by which they repair DUs. summarize pathological process DUs review various additives used Finally, examine limitations obstacles exist development clinically relevant applications these appealing technologies. This defines carefully diabetic (DUs), summarizes DUs, reviews bioactivators
Language: Английский
Citations
32
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4738 - 4738
Published: March 1, 2023
Numerous studies have shown that oxidative stress resulting from an imbalance between the production of free radicals and their neutralization by antioxidant enzymes is one major pathological disorders underlying development progression type 2 diabetes (T2D). The present review summarizes current state art advances in understanding role abnormal redox homeostasis molecular mechanisms T2D provides comprehensive information on characteristics biological functions enzymes, as well discusses genetic conducted so far order to investigate contribution polymorphisms genes encoding state-regulating disease pathogenesis.
Language: Английский
Citations
24
Biomolecules, Journal Year: 2024, Volume and Issue: 14(1), P. 137 - 137
Published: Jan. 22, 2024
Kidney fibrosis, diffused into the interstitium, vessels, and glomerulus, is main pathologic feature associated with loss of renal function chronic kidney disease (CKD). Fibrosis may be triggered in diseases by different genetic molecular insults. However, several studies have shown that fibrosis can linked to oxidative stress mitochondrial dysfunction CKD. In this review, we will focus on three pathways link namely: (i) hyperglycemia energy imbalance, (ii) mineralocorticoid signaling pathway, (iii) hypoxia-inducible factor (HIF) pathway. We selected these because they are targeted available medications capable reducing such as sodium-glucose cotransporter-2 (SGLT2) inhibitors, non-steroidal receptor antagonists (MRAs), HIF-1alpha-prolyl hydroxylase inhibitors. These drugs a reduction reduced collagen deposition across CKD subtypes. there still long winding road clear understanding anti-fibrotic effects compounds humans, due inherent practical ethical difficulties obtaining sequential biopsies lack specific biomarkers measurable easily accessible matrices like urine. narrative describe pathways, their interconnections, activity fibrosis.
Language: Английский
Citations
15
Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 594 - 594
Published: May 12, 2024
Diabetic retinopathy (DR) represents a severe complication of diabetes mellitus, characterized by irreversible visual impairment resulting from microvascular abnormalities. Since the global prevalence continues to escalate, DR has emerged as prominent area research interest. The development and progression encompass complex interplay pathological physiological mechanisms, such high glucose-induced oxidative stress, immune responses, vascular endothelial dysfunction, well damage retinal neurons. Recent years have unveiled involvement genomic epigenetic factors in formation mechanisms. At present, extensive explores potential biomarkers cytokines, molecular cell therapies, antioxidant interventions, gene therapy for treatment. Notably, certain drugs, anti-VEGF agents, antioxidants, inhibitors inflammatory protein kinase C (PKC)-β inhibitors, demonstrated promising outcomes clinical trials. Within this context, review article aims introduce recent on highlight current progress field, with particular focus emerging experimental treatment strategies targeting redox signaling pathways.
Language: Английский
Citations
13
Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
The balance of redox states is crucial for maintaining physiological homeostasis. For decades, the focus has been mainly on concept oxidative stress, which involved in mechanism almost all diseases. However, robust evidence highlighted that reductive other side spectrum, plays a pivotal role development various diseases, particularly those related to metabolism and cardiovascular health. In this review, we present an extensive array occurrence stress its significant implications metabolic Reductive defined as shift cellular towards more reduced state, characterized by excess endogenous reductants (such NADH, NADPH, GSH) over their oxidized counterparts (NAD+, NADP+, GSSG). While predominant studied obesity, disorders, growing underscores critical stress. This review discusses how contributes pathologies, emphasizing effects key processes. example, excessive NADH accumulation can disrupt mitochondrial function impairing electron transport chain, leading decreased ATP production increased reactive oxygen species. endoplasmic reticulum (ER), equivalents hampers protein folding, triggering ER activating unfolded response, lead insulin resistance compromised Furthermore, explore antioxidant supplementation exacerbate further shifting balance, potentially undermining beneficial exercise, health, aggravating obese individuals. body calls reevaluation disease pathogenesis therapeutic interventions.
Language: Английский
Citations
1