Epigenetic regulation of T cell exhaustion DOI
Julia A. Belk, Bence Dániel, Ansuman T. Satpathy

et al.

Nature Immunology, Journal Year: 2022, Volume and Issue: 23(6), P. 848 - 860

Published: May 27, 2022

Language: Английский

Dynamics and function of DNA methylation in plants DOI
Huiming Zhang,

Zhaobo Lang,

Jian‐Kang Zhu

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2018, Volume and Issue: 19(8), P. 489 - 506

Published: May 21, 2018

Language: Английский

Citations

1388
DNA methylation aging clocks: challenges and recommendations DOI Creative Commons
Christopher G. Bell, Robert Lowe, Peter D. Adams

et al.

Genome biology, Journal Year: 2019, Volume and Issue: 20(1)

Published: Nov. 25, 2019

Abstract Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These are acknowledged as highly accurate molecular correlate chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates test longevity or rejuvenating interventions. Here, we discuss key challenges understand clock mechanisms biomarker utility. This requires dissecting the drivers regulators age-related changes single-cell, tissue- disease-specific models, well exploring epigenomic marks, longitudinal diverse population studies, non-human models. We also highlight important ethical issues forensic determination predicting trajectory an individual.

Language: Английский

Citations

782
Reprogramming to recover youthful epigenetic information and restore vision DOI
Yuancheng Ryan Lu, Benedikt Brommer, Xiao Tian

et al.

Nature, Journal Year: 2020, Volume and Issue: 588(7836), P. 124 - 129

Published: Dec. 2, 2020

Language: Английский

Citations

618
DNA Methylation Clocks in Aging: Categories, Causes, and Consequences DOI Creative Commons
Adam E. Field, Neil Robertson, Tina Wang

et al.

Molecular Cell, Journal Year: 2018, Volume and Issue: 71(6), P. 882 - 895

Published: Sept. 1, 2018

Language: Английский

Citations

507
The impact of cellular metabolism on chromatin dynamics and epigenetics DOI
Michael A. Reid, Ziwei Dai, Jason W. Locasale

et al.

Nature Cell Biology, Journal Year: 2017, Volume and Issue: 19(11), P. 1298 - 1306

Published: Oct. 23, 2017

Language: Английский

Citations

440
Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer DOI
Andrew W. Caliri, Stella Tommasi, Ahmad Besaratinia

et al.

Mutation Research/Reviews in Mutation Research, Journal Year: 2021, Volume and Issue: 787, P. 108365 - 108365

Published: Jan. 1, 2021

Language: Английский

Citations

405
Regulation of transposable elements by DNA modifications DOI
Özgen Deniz, Jennifer M. Frost, Miguel R. Branco

et al.

Nature Reviews Genetics, Journal Year: 2019, Volume and Issue: 20(7), P. 417 - 431

Published: March 12, 2019

Language: Английский

Citations

401
DNA methylation profiles in cancer diagnosis and therapeutics DOI
Yunbao Pan, Guohong Liu, Fuling Zhou

et al.

Clinical and Experimental Medicine, Journal Year: 2017, Volume and Issue: 18(1), P. 1 - 14

Published: July 27, 2017

Language: Английский

Citations

334
The language of chromatin modification in human cancers DOI
Shuai Zhao, C. David Allis, Gang Greg Wang

et al.

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(7), P. 413 - 430

Published: May 17, 2021

Language: Английский

Citations

293
Epigenetic regulation of the innate immune response to infection DOI
Qian Zhang, Xuetao Cao

Nature reviews. Immunology, Journal Year: 2019, Volume and Issue: 19(7), P. 417 - 432

Published: March 27, 2019

Language: Английский

Citations

288