Nature Genetics, Journal Year: 2016, Volume and Issue: 49(2), P. 213 - 222
Published: Dec. 12, 2016
Language: Английский
Trends in Neurosciences, Journal Year: 2018, Volume and Issue: 41(9), P. 587 - 598
Published: June 7, 2018
Language: Английский
Citations
317
Nature Genetics, Journal Year: 2014, Volume and Issue: 46(4), P. 380 - 384
Published: Feb. 16, 2014
Language: Английский
Citations
315
Neuron, Journal Year: 2013, Volume and Issue: 80(3), P. 624 - 632
Published: Oct. 1, 2013
Language: Английский
Citations
304
The Neuroscientist, Journal Year: 2015, Volume and Issue: 22(5), P. 447 - 463
Published: Oct. 9, 2015
Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in neural circuit structure and function as well likely abnormalities glial cells. While genetic factors important the etiology of most mental disorders, relatively high rates discordance among identical twins, particularly for depression other stress-related syndromes, clearly indicate importance additional mechanisms. Environmental such stress known to play a role onset these illnesses. Exposure environmental insults induces stable changes gene expression, function, ultimately behavior, maladaptations appear distinct between developmental versus adult exposures. Increasing evidence indicates that sustained maintained by epigenetic modifications specific brain regions. Indeed, transcriptional dysregulation aberrant regulation underlies this is unifying theme psychiatric disorders. Here, we provide progress report studies three major depression, schizophrenia, bipolar disorder. We review literature derived from animal models postmortem tissue human patients. illness remain at early stages, understanding how recruit machinery within regions cause lasting disease susceptibility pathophysiology revealing new insight into treatment conditions.
Language: Английский
Citations
299
Nature Genetics, Journal Year: 2016, Volume and Issue: 49(2), P. 213 - 222
Published: Dec. 12, 2016
Language: Английский
Citations
272