Nature and mental health: An ecosystem service perspective

Science Advances, Journal Year: 2019, Volume and Issue: 5(7)

Published: July 5, 2019

A growing body of empirical evidence is revealing the value nature experience for mental health. With rapid urbanization and declines in human contact with globally, crucial decisions must be made about how to preserve enhance opportunities experience. Here, we first provide points consensus across natural, social, health sciences on impacts cognitive functioning, emotional well-being, other dimensions We then show ecosystem service assessments can expanded include health, a heuristic, conceptual model doing so.

Language: Английский

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Activity-Regulated Transcription: Bridging the Gap between Neural Activity and Behavior

Neuron, Journal Year: 2018, Volume and Issue: 100(2), P. 330 - 348

Published: Oct. 1, 2018

Language: Английский

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The fetal origins of mental illness

American Journal of Obstetrics and Gynecology, Journal Year: 2019, Volume and Issue: 221(6), P. 549 - 562

Published: June 15, 2019

Language: Английский

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The Corticotropin-Releasing Factor Family: Physiology of the Stress Response

Physiological Reviews, Journal Year: 2018, Volume and Issue: 98(4), P. 2225 - 2286

Published: Aug. 15, 2018

The physiological stress response is responsible for the maintenance of homeostasis in presence real or perceived challenges. In this function, brain activates adaptive responses that involve numerous neural circuits and effector molecules to adapt current future demands. A maladaptive has been linked etiology a variety disorders, such as anxiety mood eating metabolic syndrome. neuropeptide corticotropin-releasing factor (CRF) its relatives, urocortins 1–3, concert with their receptors (CRFR1, CRFR2), have emerged central components response. This peptidergic system impinges on broad spectrum processes are basis successful adaptation concomitantly integrate autonomic, neuroendocrine, behavioral responses. review focuses physiology CRF-related peptides cognate aim providing comprehensive up-to-date overview field. We describe major molecular features covering aspects gene expression regulation, structural properties, interactions, well mechanisms signal transduction surveillance. addition, we discuss large body published experimental studies focusing state-of-the-art genetic approaches high temporal spatial precision, which collectively aimed dissect contribution ligands different levels controversies field unravel knowledge gaps might pave way research directions open up novel opportunities therapeutic intervention.

Language: Английский

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The Epigenetic Link between Prenatal Adverse Environments and Neurodevelopmental Disorders

Genes, Journal Year: 2017, Volume and Issue: 8(3), P. 104 - 104

Published: March 18, 2017

Prenatal adverse environments, such as maternal stress, toxicological exposures, and viral infections, can disrupt normal brain development contribute to neurodevelopmental disorders, including schizophrenia, depression, autism. Increasing evidence shows that these short- long-term effects of prenatal exposures on structure function are mediated by epigenetic mechanisms. Animal studies demonstrate exposure toxins, mimetics, drugs induces lasting changes in the brain, genes encoding glucocorticoid receptor (Nr3c1) brain-derived neurotrophic factor (Bdnf). These have been linked gene expression, stress reactivity, behavior, often times, shown be dependent gestational window exposure, sex, level. Although from human is more limited, environmental risks humans associated with peripheral tissues, future required understand whether we use biomarkers predict neurobehavioral outcomes. An extensive research effort combining well-designed animal studies, comprehensive epigenomic analyses tissues over time, will necessary improve our understanding basis disorders.

Language: Английский

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Socioeconomic status and the brain: prospects for neuroscience-informed policy

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 19(7), P. 428 - 438

Published: June 4, 2018

Language: Английский

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Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms

Pharmacological Reviews, Journal Year: 2020, Volume and Issue: 73(1), P. 202 - 277

Published: Dec. 16, 2020

Mounting evidence suggests safety and efficacy of psychedelic compounds as potential novel therapeutics in psychiatry. Ketamine has been approved by the Food Drug Administration a new class antidepressants, 3,4-methylenedioxymethamphetamine (MDMA) is undergoing phase III clinical trials for post-traumatic stress disorder. Psilocybin lysergic acid diethylamide (LSD) are being investigated several II I trials. Hence, concept psychedelics may be incorporated into modern society. Here, we discuss main known neurobiological therapeutic mechanisms psychedelics, which thought to mediated effects these on serotonergic (via 5-HT_2A 5-HT_1A receptors) glutamatergic [via N-methyl-d-aspartate (NMDA) α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic (AMPA) receptors] systems. We focus 1) neuroplasticity modulation mammalian target rapamycin–, brain-derived neurotrophic factor–, early growth response–related pathways; 2) immunomodulation via hypothalamic-pituitary-adrenal axis, nuclear factor ĸB, cytokines such tumor necrosis factor-α interleukin 1, 6, 10 production release; 3) serotonergic, dopaminergic, glutamatergic, GABAergic, norepinephrinergic receptors, transporters, turnover arising concerns ways assess changes, dependence, immunosuppression. Although larger cohorts required corroborate preliminary findings, results obtained so far promising represent critical opportunity improvement pharmacotherapies psychiatry, an area that seen limited advancement last 20 years. Studies underway trying decouple from compounds.

Significance Statement

Psychedelic emerging However, understanding molecular mediating remains limited. This paper reviews available concerning pathways modulate neuroplasticity, immunity, neurotransmitter work aims reference psychiatrists who soon faced with possibility prescribing medications, helping them compound(s) regimen could most useful decreasing specific psychiatric symptoms.

Language: Английский

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Childhood Trauma in Schizophrenia: Current Findings and Research Perspectives

Frontiers in Neuroscience, Journal Year: 2019, Volume and Issue: 13

Published: March 21, 2019

Schizophrenia is a severe neuropsychiatric disorder with persistence of symptoms throughout adult life in most the affected patients. This unfavorable course associated multiple episodes and residual symptoms, mainly negative cognitive deficits. The neural diathesis-stress model proposes that psychosocial stress acts on pre-existing vulnerability thus triggers schizophrenia. Childhood trauma form renders individuals more vulnerable to developing schizophrenia; neurobiological effects such endocrine system epigenetic mechanisms are discussed. impaired working memory, executive function, verbal learning, attention schizophrenia patients, including those at ultra-high risk develop psychosis. In these higher levels childhood were correlated attenuated positive general depressive symptoms; lower global functioning; poorer performance visual episodic memory end functions. this review, we discuss specific gene variants interact patients describe new findings brain structural functional level. Additive between brain-derived neurotrophic factor methionine carriers volume loss hippocampal subregions cornu ammonis (CA)4/dentate gyrus CA2/3 have been reported A magnetic resonance imaging study showed exposure resulted aberrant function parietal areas involved cortical attention. theory mind task reflecting social cognition, was activation posterior cingulate gyrus, precuneus, dorsomedial prefrontal cortex addition, decreased connectivity shown cingulate/precuneus region amygdala high physical neglect sexual abuse during childhood, suggesting disturbances networks underlie abilities. Finally, some questionnaires commonly used assess outline possibilities use recent biostatistical methods, as machine analyze resulting datasets.

Language: Английский

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Epigenetic Modifications in Schizophrenia and Related Disorders: Molecular Scars of Environmental Exposures and Source of Phenotypic Variability

Biological Psychiatry, Journal Year: 2020, Volume and Issue: 89(3), P. 215 - 226

Published: March 28, 2020

Epigenetic modifications are increasingly recognized to play a role in the etiology and pathophysiology of schizophrenia other psychiatric disorders with developmental origins. Here, we summarize clinical preclinical findings epigenetic alterations relevant disease models discuss their putative origin. Recent suggest that certain risk loci can influence stochastic variation gene expression through processes, highlighting intricate interaction between genetic control neurodevelopmental trajectories. In addition, substantial portion related may be acquired environmental factors manifested as molecular "scars." Some these scars brain functions throughout entire lifespan even transmitted across generations via germline inheritance. modifications, whether caused by or factors, plausible sources phenotypic heterogeneity offer target for therapeutic interventions. The further elucidation thus increase our knowledge regarding schizophrenia's heterogeneous and, long term, advance personalized treatments use biomarker-guided

Language: Английский

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Genome-wide DNA Methylation Changes in a Mouse Model of Infection-Mediated Neurodevelopmental Disorders

Biological Psychiatry, Journal Year: 2016, Volume and Issue: 81(3), P. 265 - 276

Published: Aug. 12, 2016

Language: Английский

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