Human immunology and immunotherapy: main achievements and challenges

Cellular and Molecular Immunology, Journal Year: 2020, Volume and Issue: 18(4), P. 805 - 828

Published: Sept. 2, 2020

Language: Английский

---

Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma

Science Immunology, Journal Year: 2020, Volume and Issue: 5(48)

Published: June 12, 2020

Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma reveals new cell subsets.

Language: Английский

---

Clonal expansion and activation of tissue-resident memory-like T _H 17 cells expressing GM-CSF in the lungs of patients with severe COVID-19

Science Immunology, Journal Year: 2021, Volume and Issue: 6(56)

Published: Feb. 12, 2021

Tissue-resident memory-like T H 17 cells are clonally expanded in bronchoalveolar lavage fluid of patients with severe COVID-19.

Language: Английский

---

CD4 T-Cell Subsets and the Pathophysiology of Inflammatory Bowel Disease

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2696 - 2696

Published: Jan. 31, 2023

Inflammatory bowel disease (IBD) is an umbrella term for the chronic immune-mediated idiopathic inflammation of gastrointestinal tract, manifesting as Crohn's (CD) or ulcerative colitis (UC). IBD characterized by exacerbated innate and adaptive immunity in gut association with microbiota dysbiosis disruption intestinal barrier, resulting increased bacterial exposure. In response to signals from microorganisms damaged tissue, immune cells produce inflammatory cytokines factors that stimulate T B system, a prominent characteristic patients accumulation T-cells their proinflammatory-associated tissue. Upon antigen recognition activation, CD4 differentiate towards range distinct phenotypes: helper(h)1, Th2, Th9, Th17, Th22, follicular helper (Tfh), several types T-regulatory (Treg). are generated according adapt microenvironmental conditions participate complex network interactions among other modulate further progression IBD. This review examines role most relevant IBD, highlighting how these environment interact cell populations promote inhibit development

Language: Английский

---

Heterogeneity of type 2 innate lymphoid cells

Nature reviews. Immunology, Journal Year: 2022, Volume and Issue: 22(11), P. 701 - 712

Published: March 30, 2022

Language: Английский

---