ROS Function in Redox Signaling and Oxidative Stress

Current Biology, Journal Year: 2014, Volume and Issue: 24(10), P. R453 - R462

Published: May 1, 2014

Language: Английский

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Role of Nrf2 in Oxidative Stress and Toxicity

The Annual Review of Pharmacology and Toxicology, Journal Year: 2013, Volume and Issue: 53(1), P. 401 - 426

Published: Jan. 6, 2013

Organismal life encounters reactive oxidants from internal metabolism and environmental toxicant exposure. Reactive oxygen nitrogen species cause oxidative stress are traditionally viewed as being harmful. On the other hand, controlled production of in normal cells serves useful purposes to regulate signaling pathways. counterbalanced by complex antioxidant defense systems regulated a web pathways ensure that response is adequate for body's needs. A recurrent theme oxidant cysteine thiol–based redox signaling. The nuclear factor erythroid 2–related 2 (Nrf2) an emerging regulator cellular resistance oxidants. Nrf2 controls basal induced expression array element–dependent genes physiological pathophysiological outcomes This review discusses impact on toxicity how senses regulates defense.

Language: Английский

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Interactions Between the Microbiota and the Immune System

Science, Journal Year: 2012, Volume and Issue: 336(6086), P. 1268 - 1273

Published: June 7, 2012

The large numbers of microorganisms that inhabit mammalian body surfaces have a highly coevolved relationship with the immune system. Although many these microbes carry out functions are critical for host physiology, they nevertheless pose threat breach ensuing pathologies. system plays an essential role in maintaining homeostasis resident microbial communities, thus ensuring mutualistic nature host-microbial is maintained. At same time, bacteria profoundly shape immunity. Here, we review advances our understanding interactions between and implications findings human health.

Language: Английский

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Physiological Roles of Mitochondrial Reactive Oxygen Species

Molecular Cell, Journal Year: 2012, Volume and Issue: 48(2), P. 158 - 167

Published: Oct. 1, 2012

Language: Английский

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Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

Immunity, Journal Year: 2012, Volume and Issue: 36(3), P. 401 - 414

Published: Feb. 16, 2012

Language: Английский

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K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

Immunity, Journal Year: 2013, Volume and Issue: 38(6), P. 1142 - 1153

Published: June 1, 2013

Language: Английский

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Metabolic Pathways in Immune Cell Activation and Quiescence

Immunity, Journal Year: 2013, Volume and Issue: 38(4), P. 633 - 643

Published: April 1, 2013

Language: Английский

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Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

Nature Immunology, Journal Year: 2012, Volume and Issue: 13(3), P. 255 - 263

Published: Jan. 29, 2012

Language: Английский

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Mitochondria in innate immune responses

Nature reviews. Immunology, Journal Year: 2011, Volume and Issue: 11(6), P. 389 - 402

Published: May 20, 2011

Language: Английский

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Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

Science, Journal Year: 2010, Volume and Issue: 330(6002), P. 362 - 366

Published: Oct. 14, 2010

Inflammation Response in Living Color Besides responding to microbial infection, our immune system also plays an important role sterile injury, for example, during trauma or organ necrosis. In a mouse model of liver inflammation, McDonald et al. (p. 362 ) used dynamic vivo imaging visualize the innate response, which is dominated by neutrophils. Neutrophils were rapidly recruited site inflammation through intravascular channels. Adenosine triphosphate generated from necrotic cells at injury and Nlrp3 inflammasome required neutrophils exit circulation into vascular endothelium, where they integrins adhere. A luminal chemokine gradient guided integrin-dependent, migration toward injury. Finally, formyl peptides provided signal override draw

Language: Английский

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