Neuropsychopharmacology, Journal Year: 2016, Volume and Issue: 42(1), P. 216 - 241
Published: Aug. 2, 2016
Language: Английский
Neuropsychopharmacology, Journal Year: 2016, Volume and Issue: 42(1), P. 216 - 241
Published: Aug. 2, 2016
Language: Английский
Journal of Cellular Physiology, Journal Year: 2018, Volume and Issue: 233(9), P. 6425 - 6440
Published: Jan. 10, 2018
Macrophages are heterogeneous and their phenotype functions regulated by the surrounding micro-environment. commonly exist in two distinct subsets: 1) Classically activated or M1 macrophages, which pro-inflammatory polarized lipopolysaccharide (LPS) either alone association with Th1 cytokines such as IFN-γ, GM-CSF, produce interleukin-1β (IL-1β), IL-6, IL-12, IL-23, TNF-α; 2) Alternatively M2 anti-inflammatory immunoregulatory Th2 IL-4 IL-13 IL-10 TGF-β. macrophages have different transcriptional profiles. They unique abilities destroying pathogens repair inflammation-associated injury. It is known that M1/M2 macrophage balance polarization governs fate of an organ inflammation When infection severe enough to affect organ, first exhibit release TNF-α, IL-1β, IL-23 against stimulus. But, if phase continues, it can cause tissue damage. Therefore, secrete high amounts TGF-β suppress inflammation, contribute repair, remodeling, vasculogenesis, retain homeostasis. In this review, we discuss basic biology including origin, differentiation activation, distribution, plasticity polarization, migration, antigen presentation capacity, cytokine chemokine production, metabolism, involvement microRNAs function. Secondly, protective pathogenic role subsets normal pathological pregnancy, anti-microbial defense, anti-tumor immunity, metabolic disease obesity, asthma allergy, atherosclerosis, fibrosis, wound healing, autoimmunity.
Language: Английский
Citations
3808Nature Neuroscience, Journal Year: 2013, Volume and Issue: 17(1), P. 131 - 143
Published: Dec. 8, 2013
Language: Английский
Citations
2243Critical Reviews in Immunology, Journal Year: 2012, Volume and Issue: 32(6), P. 463 - 488
Published: Jan. 1, 2012
The purpose of immunology is simple. Cure or prevent disease. M1/M2 useful because it describes the two major and opposing activities macrophages. M1 activity inhibits cell proliferation causes tissue damage while M2 promotes repair. Remarkably, molecules primarily responsible for these "Fight" (NO) "Fix" (Ornithine) both arise from arginine, via enzymatic pathways (iNOS arginase) that down regulate each other. names were chosen macrophages promote Th1 Th2 responses, respectively. Products responses (e.g., IFN-γ, IL-4) also M1activity, Thus, demonstrated importance Innate Immunity how linked to Adaptive in a beautifully counterbalanced system. "Civilization" increased longevity present new disease challenges such as cancer atherosclerosis do not display classical "foreign" antigens. And, diseases are often associated with (or caused by) M1- M2- type formerly fighting infections, but now inappropriate our increasingly "germ-free" societies. In turn, there considerable potential modulating modern achieve better health. Finally, since Th2) work concert produce characteristic immune pathologies, recommended Immune Type 1 2 (IT1, IT2) would be simpler unifying terminology going forward.
Language: Английский
Citations
1052Journal of Neuroscience, Journal Year: 2013, Volume and Issue: 33(10), P. 4216 - 4233
Published: March 6, 2013
Neurogenesis must be properly regulated to ensure that cell production does not exceed the requirements of growing cerebral cortex, yet our understanding mechanisms restrain neuron remains incomplete. We investigated function microglial cells in developing cortex prenatal and postnatal macaques rats show microglia limit cortical neurons by phagocytosing neural precursor cells. selectively colonize proliferative zones phagocytose as neurogenesis nears completion. found deactivating utero with tetracyclines or eliminating from fetal liposomal clodronate significantly increased number cells, while activating through maternal immune activation decreased These data demonstrate play a fundamental role regulating size pool expanding regulate development. Furthermore, suggest any factor alters state can profoundly affect development behavioral outcomes.
Language: Английский
Citations
897Nature, Journal Year: 2013, Volume and Issue: 497(7448), P. 211 - 216
Published: May 1, 2013
Language: Английский
Citations
785Trends in Neurosciences, Journal Year: 2013, Volume and Issue: 36(3), P. 174 - 184
Published: Jan. 5, 2013
Language: Английский
Citations
770Chemical Society Reviews, Journal Year: 2015, Volume and Issue: 44(23), P. 8576 - 8607
Published: Jan. 1, 2015
This
review
discusses
the
physiochemical
parameters,
hindering
translation
of
iron
oxide
nanoparticles
to
clinics,
using
most
recent
Language: Английский
Citations
735Handbook of experimental pharmacology, Journal Year: 2015, Volume and Issue: unknown, P. 145 - 170
Published: Jan. 1, 2015
Language: Английский
Citations
696Progress in Neurobiology, Journal Year: 2016, Volume and Issue: 157, P. 247 - 272
Published: Feb. 2, 2016
Language: Английский
Citations
652Neuron, Journal Year: 2017, Volume and Issue: 95(6), P. 1246 - 1265
Published: Sept. 1, 2017
Language: Английский
Citations
635