The Aryl Hydrocarbon Receptor: Multitasking in the Immune System DOI Open Access
Brigitta Stockinger, Paola Di Meglio, Manolis Gialitakis

et al.

Annual Review of Immunology, Journal Year: 2014, Volume and Issue: 32(1), P. 403 - 432

Published: March 21, 2014

The aryl hydrocarbon receptor (AhR), for many years almost exclusively studied by the pharmacology/toxicology field its role in mediating toxicity of xenobiotics such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), has more recently attracted attention immunologists. evolutionary conservation this transcription factor and widespread expression immune system point to important physiological functions that are slowly being unraveled. In particular, emphasis is now shifting from AhR xenobiotic pathway toward mode action response ligands. article, we review current understanding molecular interactions steady state presence infection inflammation, with a focus on barrier organs skin, gut, lung.

Language: Английский

Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis DOI
Christoph S. N. Klose, David Artis

Nature Immunology, Journal Year: 2016, Volume and Issue: 17(7), P. 765 - 774

Published: June 21, 2016

Language: Английский

Citations

854
Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-γ-Producing Cells DOI Creative Commons

Anja Fuchs,

William Vermi,

Jacob S. Lee

et al.

Immunity, Journal Year: 2013, Volume and Issue: 38(4), P. 769 - 781

Published: Feb. 28, 2013

Language: Английский

Citations

836
Antitumour actions of interferons: implications for cancer therapy DOI
Belinda S. Parker, Jai Rautela, Paul J. Hertzog

et al.

Nature reviews. Cancer, Journal Year: 2016, Volume and Issue: 16(3), P. 131 - 144

Published: Feb. 25, 2016

Language: Английский

Citations

810
Interleukin-22: Immunobiology and Pathology DOI Open Access
Jarrod A. Dudakov, Alan M. Hanash, Marcel R.M. van den Brink

et al.

Annual Review of Immunology, Journal Year: 2015, Volume and Issue: 33(1), P. 747 - 785

Published: Feb. 24, 2015

Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that produced by T helper (Th) 17 cells, γδ NKT and newly innate lymphoid cells (ILCs). Knowledge of IL-22 biology has evolved rapidly since its discovery in 2000, role for been identified numerous tissues, including the intestines, lung, liver, kidney, thymus, pancreas, skin. primarily targets nonhematopoietic epithelial stromal where it can promote proliferation play tissue regeneration. In addition, regulates host defense at barrier surfaces. However, also linked to several conditions involving inflammatory pathology. this review, we assess current understanding cytokine, physiologic pathologic effects on cell function.

Language: Английский

Citations

799
The Aryl Hydrocarbon Receptor: Multitasking in the Immune System DOI Open Access
Brigitta Stockinger, Paola Di Meglio, Manolis Gialitakis

et al.

Annual Review of Immunology, Journal Year: 2014, Volume and Issue: 32(1), P. 403 - 432

Published: March 21, 2014

The aryl hydrocarbon receptor (AhR), for many years almost exclusively studied by the pharmacology/toxicology field its role in mediating toxicity of xenobiotics such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), has more recently attracted attention immunologists. evolutionary conservation this transcription factor and widespread expression immune system point to important physiological functions that are slowly being unraveled. In particular, emphasis is now shifting from AhR xenobiotic pathway toward mode action response ligands. article, we review current understanding molecular interactions steady state presence infection inflammation, with a focus on barrier organs skin, gut, lung.

Language: Английский

Citations

798