Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy

Cell Metabolism, Journal Year: 2017, Volume and Issue: 26(1), P. 94 - 109

Published: July 1, 2017

Language: Английский

---

Emerging insights into natural killer cells in human peripheral tissues

Nature reviews. Immunology, Journal Year: 2016, Volume and Issue: 16(5), P. 310 - 320

Published: April 28, 2016

Language: Английский

---

A safe and potent anti-CD19 CAR T cell therapy

Nature Medicine, Journal Year: 2019, Volume and Issue: 25(6), P. 947 - 953

Published: April 22, 2019

Language: Английский

---

Immunosenescence: molecular mechanisms and diseases

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: May 13, 2023

Abstract Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms are linked to innate adaptive immune dysfunction that accompanies aging (known as immunosenescence). During aging, organisms tend develop a characteristic inflammatory state expresses high levels of pro-inflammatory markers, termed inflammaging. This chronic inflammation is typical phenomenon immunosenescence it considered the major risk factor for diseases. Thymic involution, naïve/memory cell ratio imbalance, dysregulated metabolism, epigenetic alterations striking features immunosenescence. Disturbed T-cell pools antigen stimulation mediate premature senescence cells, senescent cells proinflammatory senescence-associated secretory phenotype exacerbates Although underlying molecular mechanisms remain be addressed, well documented T inflammaging might driving forces in Potential counteractive measures will discussed, including intervention cellular metabolic-epigenetic axes mitigate In recent years, has attracted increasing attention its role tumor development. As result limited participation elderly patients, impact on cancer immunotherapy unclear. Despite some surprising results from clinical trials drugs, necessary investigate other

Language: Английский

---

Ontogeny of early life immunity

Trends in Immunology, Journal Year: 2014, Volume and Issue: 35(7), P. 299 - 310

Published: May 28, 2014

Language: Английский

---

mRNA vaccine–induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

Journal of Clinical Investigation, Journal Year: 2020, Volume and Issue: 130(11), P. 5976 - 5988

Published: Oct. 4, 2020

BACKGROUND. Therapeutic vaccinations against cancer have mainly targeted differentiation antigens, cancer-testis and overexpressed antigens thus far resulted in little clinical benefit. Studies conducted by multiple groups demonstrated that T cells recognizing neoantigens are present most cancers offer a specific highly immunogenic target for personalized vaccination.

Language: Английский

---

Targeting the Latent Reservoir for HIV-1

Immunity, Journal Year: 2018, Volume and Issue: 48(5), P. 872 - 895

Published: May 1, 2018

Language: Английский

---

Regulatory T cell memory

Nature reviews. Immunology, Journal Year: 2015, Volume and Issue: 16(2), P. 90 - 101

Published: Dec. 21, 2015

Language: Английский

---

Heterogeneity of Human CD4⁺T Cells Against Microbes

Annual Review of Immunology, Journal Year: 2016, Volume and Issue: 34(1), P. 317 - 334

Published: May 11, 2016

CD4 + T helper (Th) cells play a central role in the adaptive immune response by providing help to B and cytotoxic releasing different types of cytokines tissues mediate protection against wide range pathogenic microorganisms. These functions are performed Th endowed with distinct migratory capacities effector functions. Here we discuss how studies human cell microbes have advanced our understanding functional heterogeneity, particular discovery Th1 subset involved Mycobacteria characterization two Th17 specific for extracellular bacteria or fungi. We also review new approaches dissect at clonal level induced pathogens vaccines that revealed an unexpected degree intraclonal diversification propose progressive selective model differentiation.

Language: Английский

---

High-dimensional single cell analysis identifies stem-like cytotoxic CD8+ T cells infiltrating human tumors

The Journal of Experimental Medicine, Journal Year: 2018, Volume and Issue: 215(10), P. 2520 - 2535

Published: Aug. 28, 2018

CD8+ T cells infiltrating tumors are largely dysfunctional, but whether a subset maintains superior functionality remains ill defined. By high-dimensional single cell analysis of millions from 53 individuals with lung cancer, we defined those subsets that enriched in compared cancer-free tissues and blood. Besides exhausted activated cells, identified CXCR5+ TIM-3– partial phenotype, while retaining gene networks responsible for stem-like plasticity cytotoxicity, as revealed by sequencing the whole transcriptome. Ex vivo, displayed enhanced self-renewal multipotency more differentiated were polyfunctional. Analysis inhibitory costimulatory receptors PD-1, TIGIT, CD27 possible targets immunotherapy. We thus demonstrate hierarchy differentiation context exhaustion human cancer similar to chronically infected mice, which is further shown disappear disease progression.

Language: Английский

---