Natural killer cells: a promising immunotherapy for cancer DOI Creative Commons
Junfeng Chu,

Fengcai Gao,

Meimei Yan

et al.

Journal of Translational Medicine, Journal Year: 2022, Volume and Issue: 20(1)

Published: May 23, 2022

Abstract As a promising alternative platform for cellular immunotherapy, natural killer cells (NK) have recently gained attention as an important type of innate immune regulatory cell. NK can rapidly kill multiple adjacent cancer through non-MHC-restrictive effects. Although tumors may develop resistance mechanisms to endogenous cell attack, in vitro activation, expansion, and genetic modification greatly enhance their anti-tumor activity give them the ability overcome drug resistance. Some these approaches been translated into clinical applications, trials infusion patients with hematological malignancies solid thus far yielded many encouraging results. CAR-T exhibited great success treating malignancies, but drawbacks include high manufacturing costs potentially fatal toxicity, such cytokine release syndrome. To issues, CAR-NK were generated engineering demonstrated significant responses lower adverse effects compared therapy. In this review, we summarize recent advances focusing on biology function, types therapy, future perspectives

Language: Английский

Cholangiocarcinoma 2020: the next horizon in mechanisms and management DOI Creative Commons
Jesús M. Bañales, José J.G. Marı́n, Ángela Lamarca

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2020, Volume and Issue: 17(9), P. 557 - 588

Published: June 30, 2020

Abstract Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant tumours that can arise at any point the tree. Their incidence is increasing globally, currently accounting for ~15% all primary liver cancers and ~3% gastrointestinal malignancies. The silent presentation these combined with their aggressive nature refractoriness to chemotherapy contribute alarming mortality, representing ~2% cancer-related deaths worldwide yearly. current diagnosis CCA by non-invasive approaches not accurate enough, histological confirmation necessary. Furthermore, high heterogeneity CCAs genomic, epigenetic molecular levels severely compromises efficacy available therapies. In past decade, efforts have been made understand complexity develop new diagnostic tools therapies might help improve patient outcomes. this expert Consensus Statement, which endorsed European Network Study Cholangiocarcinoma, we aim summarize critically discuss latest advances in CCA, mostly focusing on classification, cells origin, genetic abnormalities, alterations, biomarker discovery treatments. horizon next decade from 2020 onwards highlighted.

Language: Английский

Citations

1739
The Broad Spectrum of Human Natural Killer Cell Diversity DOI Creative Commons
Aharon G. Freud, Bethany L. Mundy-Bosse, Jianhua Yu

et al.

Immunity, Journal Year: 2017, Volume and Issue: 47(5), P. 820 - 833

Published: Nov. 1, 2017

Language: Английский

Citations

582
NK cell-based cancer immunotherapy: from basic biology to clinical development DOI Creative Commons
Sizhe Liu, Vasiliy Galat, Yekaterina Galat

et al.

Journal of Hematology & Oncology, Journal Year: 2021, Volume and Issue: 14(1)

Published: Jan. 6, 2021

Abstract Natural killer (NK) cell is a specialized immune effector type that plays critical role in activation against abnormal cells. Different from events required for T activation, NK governed by the interaction of receptors with target cells, independent antigen processing and presentation. Due to relatively unsophisticated cues has gained significant attention field cancer immunotherapy. Many efforts are emerging developing engineering cell-based In this review, we provide our current understandings biology, ongoing pre-clinical clinical development therapies discuss progress, challenges, future perspectives.

Language: Английский

Citations

500
The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity DOI Creative Commons
Marcin F. Osuchowski, Martin Sebastian Winkler, Tomasz Skirecki

et al.

The Lancet Respiratory Medicine, Journal Year: 2021, Volume and Issue: 9(6), P. 622 - 642

Published: May 7, 2021

The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with devastating consequences. While the medical community has gained insight into epidemiology of COVID-19, important questions remain about clinical complexities and underlying mechanisms disease phenotypes. Severe most commonly involves respiratory manifestations, although other systems are also affected, acute is often followed by protracted complications. Such complex manifestations suggest dysregulates host response, triggering wide-ranging immuno-inflammatory, thrombotic, parenchymal derangements. We review intricacies pathophysiology, its various phenotypes, anti-SARS-CoV-2 response at humoral cellular levels. Some similarities exist between failure origins, but evidence for many distinctive mechanistic features indicates constitutes a new entity, emerging data suggesting involvement an endotheliopathy-centred pathophysiology. Further research, combining basic studies, needed advance understanding pathophysiological characterise immuno-inflammatory derangements across range phenotypes enable optimum care patients COVID-19.

Language: Английский

Citations

479
Natural killer cell immunotypes related to COVID-19 disease severity DOI Creative Commons
Christopher Maucourant, Iva Filipovic, Andrea Ponzetta

et al.

Science Immunology, Journal Year: 2020, Volume and Issue: 5(50)

Published: Aug. 14, 2020

Understanding innate immune responses in COVID-19 is important to decipher mechanisms of host and interpret disease pathogenesis. Natural killer (NK) cells are effector lymphocytes that respond acute viral infections but might also contribute immunopathology. Using 28-color flow cytometry, we here reveal strong NK cell activation across distinct subsets peripheral blood patients. This pattern was mirrored scRNA-seq signatures bronchoalveolar lavage from Unsupervised high-dimensional analysis furthermore identified immunotypes were linked severity. Hallmarks these high expression perforin, NKG2C, Ksp37, reflecting increased presence adaptive circulation patients with severe disease. Finally, arming CD56bright observed states, driven by a defined protein-protein interaction network inflammatory soluble factors. study provides detailed map the landscape

Language: Английский

Citations

435
Natural killer cells in antiviral immunity DOI Open Access
Niklas K. Björkström, Benedikt Strunz, Hans‐Gustaf Ljunggren

et al.

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 22(2), P. 112 - 123

Published: June 11, 2021

Language: Английский

Citations

360
Regulation of Placental Extravillous Trophoblasts by the Maternal Uterine Environment DOI Creative Commons
Jürgen Pollheimer, Sigrid Vondra, Jennet Baltayeva

et al.

Frontiers in Immunology, Journal Year: 2018, Volume and Issue: 9

Published: Nov. 13, 2018

During placentation invasive extravillous trophoblasts (EVTs) migrate into the maternal uterus and modify its vessels. In particular, remodelling of spiral arteries by EVTs is critical for adapting blood flow nutrient transport to developing fetus. Failures in this process have been noticed different pregnancy complications such as preeclampsia, intrauterine growth restriction, stillbirth or recurrent abortion. Upon invasion decidua, endometrium pregnancy, encounter cell types decidual macrophages, uterine NK (uNK) cells stromal expressing a plethora factors cytokines. Here, we will summarise development EVT lineage, occurring independently environment, formation subtypes. Further, discuss interactions with arteries, veins lymphatics illustrate how decidua immune regulate differentiation, survival. The present literature suggests that environment soluble critically modulate function reproductive success.

Language: Английский

Citations

323
Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression DOI Creative Commons

Jingjing Cong,

Xianwei Wang, Xiaohu Zheng

et al.

Cell Metabolism, Journal Year: 2018, Volume and Issue: 28(2), P. 243 - 255.e5

Published: July 20, 2018

Language: Английский

Citations

294
NK cells switch from granzyme B to death receptor–mediated cytotoxicity during serial killing DOI Creative Commons

Isabel Prager,

Clarissa Liesche,

Hanna van Ooijen

et al.

The Journal of Experimental Medicine, Journal Year: 2019, Volume and Issue: 216(9), P. 2113 - 2127

Published: July 3, 2019

NK cells eliminate virus-infected and tumor by releasing cytotoxic granules containing granzyme B (GrzB) or engaging death receptors that initiate caspase cascades. The orchestrated interplay between both cell pathways remains poorly defined. Here we simultaneously measure the activities of GrzB caspase-8 in upon contact with human cells. We observed switch from inducing a fast GrzB-mediated their first killing events to slow receptor–mediated during subsequent encounters. Target reduced intracellular perforin increased surface-CD95L over time, showing how cytotoxicity is controlled. Without perforin, were unable perform serial only killed once via receptors. In contrast, absence CD95 on targets did not impair killing. This demonstrates are differentially regulated

Language: Английский

Citations

292
The Immunomodulatory Functions of Mesenchymal Stromal/Stem Cells Mediated via Paracrine Activity DOI Open Access

Yueyuan Zhou,

Yusuke Yamamoto, Zhongdang Xiao

et al.

Journal of Clinical Medicine, Journal Year: 2019, Volume and Issue: 8(7), P. 1025 - 1025

Published: July 12, 2019

Mesenchymal stromal/stem cells (MSCs) exist in almost all tissues, possessing the potential to differentiate into specialized cell types and exert immunomodulatory functions. Thus, they have attracted much attention as a promising therapeutic candidate. Recent studies demonstrated that paracrine signaling is mainly responsible for involvement of MSCs modulation immune responses progression diseases. Through release secretome consisting diverse range cytokines, chemokines, extracellular vesicles (EVs), convey regulatory messages recipient microenvironment. In this review, we focus on recent advances how contribute immunomodulation through secretion factors. The further improved understanding molecular mechanism underlying interactions between highlights biology microenvironment promotes clinical application regenerative medicine

Language: Английский

Citations

263