Tissue macrophages: heterogeneity and functions

BMC Biology, Journal Year: 2017, Volume and Issue: 15(1)

Published: June 29, 2017

Macrophages are present in all vertebrate tissues, from mid-gestation throughout life, constituting a widely dispersed organ system. They promote homeostasis by responding to internal and external changes within the body, not only as phagocytes defence against microbes clearance of dead senescent cells, but also through trophic, regulatory repair functions. In this review, we describe macrophage phenotypic heterogeneity different tissue environments, drawing particular attention organ-specific

Language: Английский

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Long noncoding RNAs in cancer metastasis

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(7), P. 446 - 460

Published: May 5, 2021

Language: Английский

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Tumor microenvironment participates in metastasis of pancreatic cancer

Molecular Cancer, Journal Year: 2018, Volume and Issue: 17(1)

Published: July 30, 2018

Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early diagnosis and metastasis. The tumor microenvironment induced by interactions between pancreatic epithelial/cancer cells stromal critical for progression has been implicated the failure of chemotherapy, radiation therapy immunotherapy. Microenvironment formation requires cells. Components that contribute desmoplasia immunosuppression are associated poor patient prognosis. These components can facilitate primary metastatic sites or promote metastasis stimulating angiogenesis/lymphangiogenesis, epithelial-mesenchymal transition, invasion/migration, pre-metastatic niche formation. Some molecules participate both In this review, we focus on mechanisms discuss how participates metastasis, representing potential target combination enhance overall survival.

Language: Английский

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Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages

Journal of Clinical Investigation, Journal Year: 2015, Volume and Issue: 125(9), P. 3365 - 3376

Published: Aug. 31, 2015

The generation of an inflammatory environment is favorable and often decisive for the growth both primary tumors metastases. Tumor cells either express membrane molecules or release tumor-derived soluble factors able to alter myelopoiesis. Tumor-reprogrammed myeloid not only create a tolerogenic by blocking T cell functions proliferation, but also directly drive tumor promoting cancer stemness, angiogenesis, stroma deposition, epithelial-to-mesenchymal transition, metastasis formation. In this Review, we discuss interplay between immunosuppressive protumoral detail their immune-regulatory mechanisms, molecular pathways involved in differentiation, as well potential role prognostic diagnostic biomarkers prospective targets innovative approaches treat tumor-bearing hosts.

Language: Английский

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Cancer Stem Cells: The Architects of the Tumor Ecosystem

Cell stem cell, Journal Year: 2019, Volume and Issue: 24(1), P. 41 - 53

Published: Jan. 1, 2019

Language: Английский

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