The molecular machinery of regulated cell death

Cell Research, Journal Year: 2019, Volume and Issue: 29(5), P. 347 - 364

Published: April 4, 2019

Cells may die from accidental cell death (ACD) or regulated (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel non-apoptotic forms have been identified are increasingly being implicated in various human pathologies. Here, we critically review the current state art regarding types RCD, including necroptosis, pyroptosis, ferroptosis, entotic death, netotic parthanatos, lysosome-dependent autophagy-dependent alkaliptosis oxeiptosis. The in-depth comprehension each these lethal subroutines their intercellular consequences uncover therapeutic targets for avoidance pathogenic loss.

Language: Английский

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cGAS surveillance of micronuclei links genome instability to innate immunity

Nature, Journal Year: 2017, Volume and Issue: 548(7668), P. 461 - 465

Published: July 20, 2017

Language: Английский

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RIG-I-like receptors: their regulation and roles in RNA sensing

Nature reviews. Immunology, Journal Year: 2020, Volume and Issue: 20(9), P. 537 - 551

Published: March 13, 2020

Language: Английский

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Cytoplasmic chromatin triggers inflammation in senescence and cancer

Nature, Journal Year: 2017, Volume and Issue: 550(7676), P. 402 - 406

Published: Oct. 1, 2017

Language: Английский

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Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 9

Published: March 29, 2021

Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells response to various intrinsic and extrinsic stimuli, as well developmental signals. Senescence considered highly dynamic, multi-step process, during which the properties of senescent continuously evolve diversify context dependent manner. It associated with multiple cellular molecular changes distinct phenotypic alterations, including proliferation unresponsive mitogenic stimuli. Senescent remain viable, have alterations metabolic activity undergo dramatic gene expression develop complex senescence-associated secretory phenotype. compromise tissue repair regeneration, thereby contributing toward aging. Removal attenuate age-related dysfunction extend health span. also act potent anti-tumor mechanism, by preventing potentially cancerous cells. program acts double-edged sword, both beneficial detrimental effects on organism, an example evolutionary antagonistic pleiotropy. Activation p53/p21 WAF1/CIP1 p16 INK4A /pRB tumor suppressor pathways play central role regulating senescence. Several other recently been implicated mediating Herein we review mechanisms underlie growth particular focus why stop dividing, stability arrest, hypersecretory phenotype how different are all integrated.

Language: Английский

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Rethinking cancer nanotheranostics

Nature Reviews Materials, Journal Year: 2017, Volume and Issue: 2(7)

Published: May 9, 2017

Language: Английский

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Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

Nature Cell Biology, Journal Year: 2017, Volume and Issue: 19(9), P. 1061 - 1070

Published: July 31, 2017

Language: Английский

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The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

Cancer Discovery, Journal Year: 2019, Volume and Issue: 10(1), P. 26 - 39

Published: Dec. 18, 2019

The recognition of DNA as an immune-stimulatory molecule is evolutionarily conserved mechanism to initiate rapid innate immune responses against microbial pathogens. cGAS-STING pathway was discovered important DNA-sensing machinery in immunity and viral defense. Recent advances have now expanded the roles cancer. Highly aggressive, unstable tumors evolved co-opt this program drive tumorigenic behaviors. In review, we discuss link between antitumor well cancer progression, genomic instability, tumor microenvironment, pharmacologic strategies for therapy. SIGNIFICANCE: defense infections. Given its role activating surveillance, it has been assumed that primarily functions a suppressor. Yet, mounting evidence suggests depending on context, signaling can also metastasis-promoting functions, chronic activation paradoxically induce immune-suppressive microenvironment.

Language: Английский

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Targeting STING with covalent small-molecule inhibitors

Nature, Journal Year: 2018, Volume and Issue: 559(7713), P. 269 - 273

Published: July 1, 2018

Language: Английский

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Mitochondrial DNA in innate immune responses and inflammatory pathology

Nature reviews. Immunology, Journal Year: 2017, Volume and Issue: 17(6), P. 363 - 375

Published: April 10, 2017

Language: Английский

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