Recent Progress in Ferroptosis Inducers for Cancer Therapy

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(51)

Published: Oct. 8, 2019

Abstract Ferroptosis is a newly discovered form of regulated cell death that the nexus between metabolism, redox biology, and human health. Emerging evidence shows potential triggering ferroptosis for cancer therapy, particularly eradicating aggressive malignancies are resistant to traditional therapies. Recently, there has been great deal effort design develop anticancer drugs based on induction. Recent advances ferroptosis‐inducing agents at intersection chemistry, materials science, biology presented. The basis summarized first highlight feasibility characteristics therapy. A literature review inducers (including small molecules nanomaterials) then presented delineate their design, action mechanisms, applications. Finally, some considerations research spotlighted, followed by discussion challenges future development directions this burgeoning field.

Language: Английский

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Block Copolymer Micelles in Nanomedicine Applications

Chemical Reviews, Journal Year: 2018, Volume and Issue: 118(14), P. 6844 - 6892

Published: June 29, 2018

Polymeric micelles are demonstrating high potential as nanomedicines capable of controlling the distribution and function loaded bioactive agents in body, effectively overcoming biological barriers, various formulations engaged intensive preclinical clinical testing. This Review focuses on polymeric assembled through multimolecular interactions between block copolymers drugs, proteins, or nucleic acids translationable nanomedicines. The aspects involved design successful micellar carriers described detail basis type polymer/payload interaction, well interplay with interface, emphasizing chemistry engineering copolymers. By shaping these features, have been propitious for delivering a wide range therapeutics effective sensing targets body adjustment their properties response to particular stimuli, modulating activity drugs at targeted sites, even subcellular level. Finally, future perspectives imminent challenges discussed, anticipating spur further innovations.

Language: Английский

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Tumor targeting via EPR: Strategies to enhance patient responses

Advanced Drug Delivery Reviews, Journal Year: 2018, Volume and Issue: 130, P. 17 - 38

Published: May 1, 2018

Language: Английский

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Smart cancer nanomedicine

Nature Nanotechnology, Journal Year: 2019, Volume and Issue: 14(11), P. 1007 - 1017

Published: Nov. 1, 2019

Language: Английский

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Transport and interactions of nanoparticles in the kidneys

Nature Reviews Materials, Journal Year: 2018, Volume and Issue: 3(10), P. 358 - 374

Published: Aug. 3, 2018

Language: Английский

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Antimonene Quantum Dots: Synthesis and Application as Near‐Infrared Photothermal Agents for Effective Cancer Therapy

Angewandte Chemie International Edition, Journal Year: 2017, Volume and Issue: 56(39), P. 11896 - 11900

Published: June 22, 2017

Abstract Photothermal therapy (PTT) has shown significant potential for cancer therapy. However, developing nanomaterials (NMs)‐based photothermal agents (PTAs) with satisfactory conversion efficacy (PTCE) and biocompatibility remains a key challenge. Herein, new generation of PTAs based on two‐dimensional (2D) antimonene quantum dots (AMQDs) was developed by novel liquid exfoliation method. Surface modification AMQDs polyethylene glycol (PEG) significantly enhanced both stability in physiological medium. The PEG‐coated showed PTCE 45.5 %, which is higher than many other NMs‐based such as graphene, Au, MoS 2 , black phosphorus (BP). AMQDs‐based also exhibited unique feature NIR‐induced rapid degradability. Through vitro vivo studies, the demonstrated notable tumor ablation ability. This work expected to expand utility 2D (AM) biomedical applications through development an entirely PTA platform.

Language: Английский

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Emerging blood–brain-barrier-crossing nanotechnology for brain cancer theranostics

Chemical Society Reviews, Journal Year: 2019, Volume and Issue: 48(11), P. 2967 - 3014

Published: Jan. 1, 2019

Brain cancer, especially the most common type of glioblastoma, is highly invasive and known as one devastating deadly neoplasms. Despite surgical medical advances, prognosis for brain cancer patients remains dismal median survival rarely exceeds 16 months. Drug delivery to significantly hindered by existence blood-brain barrier (BBB), which serves a protective semi-permeable membrane central nervous system. Recent breakthroughs in nanotechnology have yielded multifunctional theranostic nanoplatforms with ability cross or bypass BBB, enabling accurate diagnosis effective treatment tumours. Herein, we make our efforts present comprehensive review on latest remarkable advances BBB-crossing nanotechnology, an emphasis judicious design BBB penetration, efficient tumour accumulation, precise imaging, significant inhibition cancer. The detailed elucidation this anticipated attract broad interest from researchers diverse fields participate establishment powerful theranostics.

Language: Английский

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Insights into 2D MXenes for Versatile Biomedical Applications: Current Advances and Challenges Ahead

Advanced Science, Journal Year: 2018, Volume and Issue: 5(10)

Published: July 19, 2018

Great and interdisciplinary research efforts have been devoted to the biomedical applications of 2D materials because their unique planar structure prominent physiochemical properties. Generally, ceramic-based biomaterials, fabricated by high-temperature solid-phase reactions, are preferred as bone scaffolds in hard tissue engineering controllable biocompatibility satisfactory mechanical property, but potential disease theranostics paid much less attention, mainly due lack related material functionalities for possibly entering circulating within vascular system. The emerging MXenes, a family ultrathin atomic nanosheet derived from MAX phase ceramics, currently booming novel inorganic nanosystems biologic applications. metallic conductivity, hydrophilic nature, other performances make it possible MXenes meet strict requirements biomedicine. This work introduces very recent progress paradigms state-of-the-art applications, focusing on design/synthesis strategies, therapeutic modalities, diagnostic imaging, biosensing, antimicrobial, biosafety issues. It is highly expected that elaborately engineered nanosheets will become one most attractive biocompatible nanoplatforms multiple extensive profit clinical translation nanomedicine.

Language: Английский

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Near‐Infrared‐Light‐Activatable Nanomaterial‐Mediated Phototheranostic Nanomedicines: An Emerging Paradigm for Cancer Treatment

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(23)

Published: March 25, 2018

Abstract Cancer is one of the most deadly diseases threatening lives humans. Although many treatment methods have been developed to tackle cancer, each modality cancer has its own limitations and drawbacks. The development minimally invasive modalities for cancers remains a great challenge. Near‐infrared (NIR) light‐activated nanomaterial‐mediated phototherapies, including photothermal photodynamic therapies, provide an alternative means spatially temporally controlled treatments cancers. Nanomaterials can serve as nanocargoes delivery chemo‐drugs, diagnostic contrast reagents, organic photosensitizers, be used directly generate heat or reactive oxygen species tumors without need photosensitizers with NIR‐light irradiation. Here, current progress in NIR‐light‐activated therapy summarized. Furthermore, effects size, shape, surface functionalities nanomaterials on intracellular uptake, macrophage clearance, biodistribution, cytotoxicities, biomedical efficacies are discussed. use various types nanomaterials, such gold nanoparticles, carbon nanotubes, graphene, other inorganic nanostructures, combination therapeutic solid tumors, briefly reviewed.

Language: Английский

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Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics

Theranostics, Journal Year: 2020, Volume and Issue: 10(10), P. 4557 - 4588

Published: Jan. 1, 2020

In recent years, much progress has been motivated in stimuli-responsive nanocarriers, which could response to the intrinsic physicochemical and pathological factors diseased regions increase specificity of drug delivery. Currently, numerous nanocarriers have engineered with changes responding external stimuli, such as ultrasound, thermal, light magnetic field, well internal including pH, redox potential, hypoxia enzyme, etc. Nanocarriers respond stimuli tumor microenvironments or inside cancer cells for on-demanded delivery accumulation, controlled release, activation bioactive compounds, probes targeting ligands, size, charge conformation conversion, etc., leading sensing signaling, overcoming multidrug resistance, accurate diagnosis precision therapy. This review summarized general strategies developing advances, presented their applications delivery, imaging, therapy theranostics, illustrated clinical translation made prospects.

Language: Английский

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