Cell adhesion: integrating cytoskeletal dynamics and cellular tension

Nature Reviews Molecular Cell Biology, Journal Year: 2010, Volume and Issue: 11(9), P. 633 - 643

Published: Aug. 23, 2010

Language: Английский

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Plasticity of cell migration: a multiscale tuning model

The Journal of Cell Biology, Journal Year: 2009, Volume and Issue: 188(1), P. 11 - 19

Published: Dec. 1, 2009

Cell migration underlies tissue formation, maintenance, and regeneration as well pathological conditions such cancer invasion. Structural molecular determinants of both environment cell behavior define whether cells migrate individually (through amoeboid or mesenchymal modes) collectively. Using a multiparameter tuning model, we describe how dimension, density, stiffness, orientation the extracellular matrix together with determinants—including cell–cell cell–matrix adhesion, cytoskeletal polarity pericellular proteolysis—interdependently control mode efficiency. Motile integrate variable inputs to adjust interactions among themselves dictate mode. The model provides parameters that movement an adaptive interconvertible process relevance different physiological contexts.

Language: Английский

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The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

Nature Reviews Molecular Cell Biology, Journal Year: 2011, Volume and Issue: 12(7), P. 413 - 426

Published: June 23, 2011

Language: Английский

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Chemotaxis in cancer

Nature reviews. Cancer, Journal Year: 2011, Volume and Issue: 11(8), P. 573 - 587

Published: July 22, 2011

Language: Английский

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Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

Cell, Journal Year: 2012, Volume and Issue: 151(7), P. 1513 - 1527

Published: Dec. 1, 2012

Language: Английский

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Engineering microscale topographies to control the cell–substrate interface

Biomaterials, Journal Year: 2012, Volume and Issue: 33(21), P. 5230 - 5246

Published: April 21, 2012

Language: Английский

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Cancer cell motility: lessons from migration in confined spaces

Nature reviews. Cancer, Journal Year: 2016, Volume and Issue: 17(2), P. 131 - 140

Published: Dec. 2, 2016

Language: Английский

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Steering cell migration: lamellipodium dynamics and the regulation of directional persistence

Nature Reviews Molecular Cell Biology, Journal Year: 2014, Volume and Issue: 15(9), P. 577 - 590

Published: Aug. 22, 2014

Language: Английский

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Matrix nanotopography as a regulator of cell function

The Journal of Cell Biology, Journal Year: 2012, Volume and Issue: 197(3), P. 351 - 360

Published: April 30, 2012

The architecture of the extracellular matrix (ECM) directs cell behavior by providing spatial and mechanical cues to which cells respond. In addition soluble chemical factors, physical interactions between ECM regulate primary processes, including differentiation, migration, proliferation. Advances in microtechnology and, more recently, nanotechnology provide a powerful means study influence on behavior. By recapitulating local architectures that encounter vivo, we can elucidate dissect fundamental signal transduction pathways control critical developmental, physiological, pathological processes.

Language: Английский

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Directional cell movement through tissues is controlled by exosome secretion

Nature Communications, Journal Year: 2015, Volume and Issue: 6(1)

Published: May 13, 2015

Abstract Directional cell movement through tissues is critical for multiple biological processes and requires maintenance of polarity in the face complex environmental cues. Here we use intravital imaging to demonstrate that secretion exosomes from late endosomes required directionally persistent efficient vivo cancer cells. Inhibiting exosome or biogenesis leads defective tumour migration associated with increased formation unstable protrusions excessive directional switching. In vitro r escue experiments purified matrix coating identify adhesion assembly as a function promotes motility. Live-cell reveals directly precedes assembly. Fibronectin found be motility-promoting cargo whose sorting into depends on binding integrins. We propose autocrine powerfully effective motility by reinforcing otherwise transient polarization states promoting

Language: Английский

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